Photopsias during Systemic Bevacizumab Therapy
Background. The authors describe a case of recurrent photopsias in a 56-year-old woman following repeat treatments with systemic intravenous bevacizumab for stage IV ovarian cancer. To our knowledge, this is the first report of photopsias following systemic bevacizumab treatments in a patient with a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Ophthalmological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/1926178 |
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| _version_ | 1832565199421308928 |
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| author | Heather Leisy Meleha Ahmad R. Theodore Smith |
| author_facet | Heather Leisy Meleha Ahmad R. Theodore Smith |
| author_sort | Heather Leisy |
| collection | DOAJ |
| description | Background. The authors describe a case of recurrent photopsias in a 56-year-old woman following repeat treatments with systemic intravenous bevacizumab for stage IV ovarian cancer. To our knowledge, this is the first report of photopsias following systemic bevacizumab treatments in a patient with a normal eye exam. Case Presentation. A 56-year-old Caucasian female complained of onset of floaters and flashes in the temporal peripheral field of the right eye 1 day after receiving intravenous of 30 g of 25 mg/mL of systemic bevacizumab for treatment of stage IV ovarian cancer. Ophthalmic examination, including dilated fundus exam, spectral domain optical coherence tomography (SD-OCT) of the optic nerve head, and enhanced depth imaging SD-OCT of the macula, revealed no significant abnormalities. Possible mechanisms are reviewed. Conclusion. We propose that patients who undergo intravenous bevacizumab treatments are questioned for any ocular symptoms and that more systematic evaluations of retinal nerve fiber layer and choroidal effects are obtained in those patients who are on long-term treatment at high doses. |
| format | Article |
| id | doaj-art-c290f4e1eb1549a39621921df39c318c |
| institution | Kabale University |
| issn | 2090-6722 2090-6730 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Ophthalmological Medicine |
| spelling | doaj-art-c290f4e1eb1549a39621921df39c318c2025-02-03T01:09:07ZengWileyCase Reports in Ophthalmological Medicine2090-67222090-67302016-01-01201610.1155/2016/19261781926178Photopsias during Systemic Bevacizumab TherapyHeather Leisy0Meleha Ahmad1R. Theodore Smith2Department of Ophthalmology, New York University School of Medicine, New York, NY 10016, USADepartment of Ophthalmology, New York University School of Medicine, New York, NY 10016, USADepartment of Ophthalmology, New York University School of Medicine, New York, NY 10016, USABackground. The authors describe a case of recurrent photopsias in a 56-year-old woman following repeat treatments with systemic intravenous bevacizumab for stage IV ovarian cancer. To our knowledge, this is the first report of photopsias following systemic bevacizumab treatments in a patient with a normal eye exam. Case Presentation. A 56-year-old Caucasian female complained of onset of floaters and flashes in the temporal peripheral field of the right eye 1 day after receiving intravenous of 30 g of 25 mg/mL of systemic bevacizumab for treatment of stage IV ovarian cancer. Ophthalmic examination, including dilated fundus exam, spectral domain optical coherence tomography (SD-OCT) of the optic nerve head, and enhanced depth imaging SD-OCT of the macula, revealed no significant abnormalities. Possible mechanisms are reviewed. Conclusion. We propose that patients who undergo intravenous bevacizumab treatments are questioned for any ocular symptoms and that more systematic evaluations of retinal nerve fiber layer and choroidal effects are obtained in those patients who are on long-term treatment at high doses.http://dx.doi.org/10.1155/2016/1926178 |
| spellingShingle | Heather Leisy Meleha Ahmad R. Theodore Smith Photopsias during Systemic Bevacizumab Therapy Case Reports in Ophthalmological Medicine |
| title | Photopsias during Systemic Bevacizumab Therapy |
| title_full | Photopsias during Systemic Bevacizumab Therapy |
| title_fullStr | Photopsias during Systemic Bevacizumab Therapy |
| title_full_unstemmed | Photopsias during Systemic Bevacizumab Therapy |
| title_short | Photopsias during Systemic Bevacizumab Therapy |
| title_sort | photopsias during systemic bevacizumab therapy |
| url | http://dx.doi.org/10.1155/2016/1926178 |
| work_keys_str_mv | AT heatherleisy photopsiasduringsystemicbevacizumabtherapy AT melehaahmad photopsiasduringsystemicbevacizumabtherapy AT rtheodoresmith photopsiasduringsystemicbevacizumabtherapy |