The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis
The gut microbiome has emerged as a pivotal area of research due to its significant influence on the immune system and cognitive functions. Cognitive disorders, including dementia and Parkinson’s disease, represent substantial global health challenges. This review explores the relationship between g...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1529958/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591661661683712 |
|---|---|
| author | Ruyi Zhang Ruyi Zhang Ning Ding Xicui Feng Wenli Liao |
| author_facet | Ruyi Zhang Ruyi Zhang Ning Ding Xicui Feng Wenli Liao |
| author_sort | Ruyi Zhang |
| collection | DOAJ |
| description | The gut microbiome has emerged as a pivotal area of research due to its significant influence on the immune system and cognitive functions. Cognitive disorders, including dementia and Parkinson’s disease, represent substantial global health challenges. This review explores the relationship between gut microbiota, immune modulation, and cognitive decline, with a particular focus on the gut-brain axis. Research indicates that gut bacteria produce metabolites, including short-chain fatty acids (SCFAs), which affect mucosal immunity, antigen presentation, and immune responses, thereby influencing cognitive functions. A noteworthy correlation has been identified between imbalances in the gut microbiome and cognitive impairments, suggesting novel pathways for the treatment of cognitive disorders. Additionally, factors such as diet, environment, and pharmaceuticals play a role in shaping the composition of the gut microbiome, subsequently impacting both immune and cognitive health. This article aims to clarify the complex interactions among gut microbiota, immune regulation, and cognitive disorders, evaluating their potential as therapeutic targets. The goal is to promote microbiome-based treatments and lay the groundwork for future research in this field. |
| format | Article |
| id | doaj-art-c2809209ac614c77829ae4b0cb5b55ff |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-c2809209ac614c77829ae4b0cb5b55ff2025-01-22T07:14:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15299581529958The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axisRuyi Zhang0Ruyi Zhang1Ning Ding2Xicui Feng3Wenli Liao4School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, ChinaBasic Medical School, Hubei University of Science and Technology, Xianning, ChinaBasic Medical School, Hubei University of Science and Technology, Xianning, ChinaSchool of Pharmacy, Hubei University of Chinese Medicine, Wuhan, ChinaBasic Medical School, Hubei University of Science and Technology, Xianning, ChinaThe gut microbiome has emerged as a pivotal area of research due to its significant influence on the immune system and cognitive functions. Cognitive disorders, including dementia and Parkinson’s disease, represent substantial global health challenges. This review explores the relationship between gut microbiota, immune modulation, and cognitive decline, with a particular focus on the gut-brain axis. Research indicates that gut bacteria produce metabolites, including short-chain fatty acids (SCFAs), which affect mucosal immunity, antigen presentation, and immune responses, thereby influencing cognitive functions. A noteworthy correlation has been identified between imbalances in the gut microbiome and cognitive impairments, suggesting novel pathways for the treatment of cognitive disorders. Additionally, factors such as diet, environment, and pharmaceuticals play a role in shaping the composition of the gut microbiome, subsequently impacting both immune and cognitive health. This article aims to clarify the complex interactions among gut microbiota, immune regulation, and cognitive disorders, evaluating their potential as therapeutic targets. The goal is to promote microbiome-based treatments and lay the groundwork for future research in this field.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1529958/fullgut microbiotaimmune modulationcognitive dysfunctiongut-brain axisshort-chain fatty acids |
| spellingShingle | Ruyi Zhang Ruyi Zhang Ning Ding Xicui Feng Wenli Liao The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis Frontiers in Immunology gut microbiota immune modulation cognitive dysfunction gut-brain axis short-chain fatty acids |
| title | The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis |
| title_full | The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis |
| title_fullStr | The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis |
| title_full_unstemmed | The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis |
| title_short | The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis |
| title_sort | gut microbiome immune modulation and cognitive decline insights on the gut brain axis |
| topic | gut microbiota immune modulation cognitive dysfunction gut-brain axis short-chain fatty acids |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1529958/full |
| work_keys_str_mv | AT ruyizhang thegutmicrobiomeimmunemodulationandcognitivedeclineinsightsonthegutbrainaxis AT ruyizhang thegutmicrobiomeimmunemodulationandcognitivedeclineinsightsonthegutbrainaxis AT ningding thegutmicrobiomeimmunemodulationandcognitivedeclineinsightsonthegutbrainaxis AT xicuifeng thegutmicrobiomeimmunemodulationandcognitivedeclineinsightsonthegutbrainaxis AT wenliliao thegutmicrobiomeimmunemodulationandcognitivedeclineinsightsonthegutbrainaxis AT ruyizhang gutmicrobiomeimmunemodulationandcognitivedeclineinsightsonthegutbrainaxis AT ruyizhang gutmicrobiomeimmunemodulationandcognitivedeclineinsightsonthegutbrainaxis AT ningding gutmicrobiomeimmunemodulationandcognitivedeclineinsightsonthegutbrainaxis AT xicuifeng gutmicrobiomeimmunemodulationandcognitivedeclineinsightsonthegutbrainaxis AT wenliliao gutmicrobiomeimmunemodulationandcognitivedeclineinsightsonthegutbrainaxis |