A Pathophysiological Insight into Sepsis and Its Correlation with Postmortem Diagnosis
Background. Sepsis is among the leading causes of death worldwide and is the focus of a great deal of attention from policymakers and caregivers. However, sepsis poses significant challenges from a clinical point of view regarding its early detection and the best organization of sepsis care. Further...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/4062829 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556217754451968 |
|---|---|
| author | C. Pomara I. Riezzo S. Bello D. De Carlo M. Neri E. Turillazzi |
| author_facet | C. Pomara I. Riezzo S. Bello D. De Carlo M. Neri E. Turillazzi |
| author_sort | C. Pomara |
| collection | DOAJ |
| description | Background. Sepsis is among the leading causes of death worldwide and is the focus of a great deal of attention from policymakers and caregivers. However, sepsis poses significant challenges from a clinical point of view regarding its early detection and the best organization of sepsis care. Furthermore, we do not yet have reliable tools for measuring the incidence of sepsis. Methods based on analyses of insurance claims are unreliable, and postmortem diagnosis is still challenging since autopsy findings are often nonspecific. Aim. The objective of this review is to assess the state of our knowledge of the molecular and biohumoral mechanisms of sepsis and to correlate them with our postmortem diagnosis ability. Conclusion. The diagnosis of sepsis-related deaths is an illustrative example of the reciprocal value of autopsy both for clinicians and for pathologists. A complete methodological approach, integrating clinical data by means of autopsy and histological and laboratory findings aiming to identify and demonstrate the host response to infectious insults, is mandatory to illuminate the exact cause of death. This would help clinicians to compare pre- and postmortem findings and to reliably measure the incidence of sepsis. |
| format | Article |
| id | doaj-art-c27ebe91be91449381a23d9eab7b026e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c27ebe91be91449381a23d9eab7b026e2025-02-03T05:45:58ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/40628294062829A Pathophysiological Insight into Sepsis and Its Correlation with Postmortem DiagnosisC. Pomara0I. Riezzo1S. Bello2D. De Carlo3M. Neri4E. Turillazzi5Department of Clinical and Experimental Medicine, Section of Forensic Pathology, Ospedale Colonnello D’Avanzo, University of Foggia, Viale degli Aviatori 1, 71100 Foggia, ItalyDepartment of Clinical and Experimental Medicine, Section of Forensic Pathology, Ospedale Colonnello D’Avanzo, University of Foggia, Viale degli Aviatori 1, 71100 Foggia, ItalyDepartment of Clinical and Experimental Medicine, Section of Forensic Pathology, Ospedale Colonnello D’Avanzo, University of Foggia, Viale degli Aviatori 1, 71100 Foggia, ItalyDepartment of Clinical and Experimental Medicine, Section of Forensic Pathology, Ospedale Colonnello D’Avanzo, University of Foggia, Viale degli Aviatori 1, 71100 Foggia, ItalyDepartment of Clinical and Experimental Medicine, Section of Forensic Pathology, Ospedale Colonnello D’Avanzo, University of Foggia, Viale degli Aviatori 1, 71100 Foggia, ItalyDepartment of Clinical and Experimental Medicine, Section of Forensic Pathology, Ospedale Colonnello D’Avanzo, University of Foggia, Viale degli Aviatori 1, 71100 Foggia, ItalyBackground. Sepsis is among the leading causes of death worldwide and is the focus of a great deal of attention from policymakers and caregivers. However, sepsis poses significant challenges from a clinical point of view regarding its early detection and the best organization of sepsis care. Furthermore, we do not yet have reliable tools for measuring the incidence of sepsis. Methods based on analyses of insurance claims are unreliable, and postmortem diagnosis is still challenging since autopsy findings are often nonspecific. Aim. The objective of this review is to assess the state of our knowledge of the molecular and biohumoral mechanisms of sepsis and to correlate them with our postmortem diagnosis ability. Conclusion. The diagnosis of sepsis-related deaths is an illustrative example of the reciprocal value of autopsy both for clinicians and for pathologists. A complete methodological approach, integrating clinical data by means of autopsy and histological and laboratory findings aiming to identify and demonstrate the host response to infectious insults, is mandatory to illuminate the exact cause of death. This would help clinicians to compare pre- and postmortem findings and to reliably measure the incidence of sepsis.http://dx.doi.org/10.1155/2016/4062829 |
| spellingShingle | C. Pomara I. Riezzo S. Bello D. De Carlo M. Neri E. Turillazzi A Pathophysiological Insight into Sepsis and Its Correlation with Postmortem Diagnosis Mediators of Inflammation |
| title | A Pathophysiological Insight into Sepsis and Its Correlation with Postmortem Diagnosis |
| title_full | A Pathophysiological Insight into Sepsis and Its Correlation with Postmortem Diagnosis |
| title_fullStr | A Pathophysiological Insight into Sepsis and Its Correlation with Postmortem Diagnosis |
| title_full_unstemmed | A Pathophysiological Insight into Sepsis and Its Correlation with Postmortem Diagnosis |
| title_short | A Pathophysiological Insight into Sepsis and Its Correlation with Postmortem Diagnosis |
| title_sort | pathophysiological insight into sepsis and its correlation with postmortem diagnosis |
| url | http://dx.doi.org/10.1155/2016/4062829 |
| work_keys_str_mv | AT cpomara apathophysiologicalinsightintosepsisanditscorrelationwithpostmortemdiagnosis AT iriezzo apathophysiologicalinsightintosepsisanditscorrelationwithpostmortemdiagnosis AT sbello apathophysiologicalinsightintosepsisanditscorrelationwithpostmortemdiagnosis AT ddecarlo apathophysiologicalinsightintosepsisanditscorrelationwithpostmortemdiagnosis AT mneri apathophysiologicalinsightintosepsisanditscorrelationwithpostmortemdiagnosis AT eturillazzi apathophysiologicalinsightintosepsisanditscorrelationwithpostmortemdiagnosis AT cpomara pathophysiologicalinsightintosepsisanditscorrelationwithpostmortemdiagnosis AT iriezzo pathophysiologicalinsightintosepsisanditscorrelationwithpostmortemdiagnosis AT sbello pathophysiologicalinsightintosepsisanditscorrelationwithpostmortemdiagnosis AT ddecarlo pathophysiologicalinsightintosepsisanditscorrelationwithpostmortemdiagnosis AT mneri pathophysiologicalinsightintosepsisanditscorrelationwithpostmortemdiagnosis AT eturillazzi pathophysiologicalinsightintosepsisanditscorrelationwithpostmortemdiagnosis |