Incidental neuroimaging findings in South African adult research participants with and without neuropsychiatric disorders
There is a lack of comparative data on the occurrence and clinical significance of incidental neuroimaging findings (IFs) in adult research participants with neuropsychiatric disorders and healthy controls. We investigated and compared the frequency, clinical significance and predictors of IFs on st...
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Elsevier
2022-12-01
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| Series: | NeuroImage: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266695602200054X |
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| author | Chanellé Hendrikse Tina Malan Stéfan du Plessis Jonathan Carr Martin Kidd Robin Emsley Soraya Seedat |
| author_facet | Chanellé Hendrikse Tina Malan Stéfan du Plessis Jonathan Carr Martin Kidd Robin Emsley Soraya Seedat |
| author_sort | Chanellé Hendrikse |
| collection | DOAJ |
| description | There is a lack of comparative data on the occurrence and clinical significance of incidental neuroimaging findings (IFs) in adult research participants with neuropsychiatric disorders and healthy controls. We investigated and compared the frequency, clinical significance and predictors of IFs on structural brain magnetic resonance imaging (MRI) scans of research participants between the ages of 18–78 years living in Cape Town, South Africa. Our sample (N = 295) included individuals with posttraumatic stress disorder (n = 122) or Parkinson's disease (n = 21), and healthy controls (n = 152). T1 ME-MPRAGE weighted structural MRI scans were acquired and subsequently reviewed for IFs by radiologists. A neurologist reviewed radiological reports and categorised IFs according to their estimated clinical significance. IFs were observed on the scans of 95 (32%) participants but most IFs were either judged to be clinically non-significant (49%) or of unknown clinical significance (32%). Eighteen participants (6%) had clinically significant findings that required referral for further clinical management. Age was a significant predictor of having an IF, whereas a diagnosis of Parkinson's disease was a significant predictor of having a clinically significant IF. |
| format | Article |
| id | doaj-art-c26cc01760ac49e7813514d2e5732489 |
| institution | OA Journals |
| issn | 2666-9560 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Reports |
| spelling | doaj-art-c26cc01760ac49e7813514d2e57324892025-08-20T02:02:33ZengElsevierNeuroImage: Reports2666-95602022-12-012410013010.1016/j.ynirp.2022.100130Incidental neuroimaging findings in South African adult research participants with and without neuropsychiatric disordersChanellé Hendrikse0Tina Malan1Stéfan du Plessis2Jonathan Carr3Martin Kidd4Robin Emsley5Soraya Seedat6Department of Psychiatry, Stellenbosch University, Cape Town, South Africa; Corresponding author. Stellenbosch University, Faculty of Medicine and Health Sciences, PO Box 241, Cape Town, 8000, South Africa.Department of Psychiatry, Stellenbosch University, Cape Town, South AfricaDepartment of Psychiatry, Stellenbosch University, Cape Town, South AfricaDepartment of Neurology, Stellenbosch University, Cape Town, South AfricaDepartment of Statistics and Actuarial Sciences, Stellenbosch University, Cape Town, South AfricaDepartment of Psychiatry, Stellenbosch University, Cape Town, South AfricaDepartment of Psychiatry, Stellenbosch University, Cape Town, South AfricaThere is a lack of comparative data on the occurrence and clinical significance of incidental neuroimaging findings (IFs) in adult research participants with neuropsychiatric disorders and healthy controls. We investigated and compared the frequency, clinical significance and predictors of IFs on structural brain magnetic resonance imaging (MRI) scans of research participants between the ages of 18–78 years living in Cape Town, South Africa. Our sample (N = 295) included individuals with posttraumatic stress disorder (n = 122) or Parkinson's disease (n = 21), and healthy controls (n = 152). T1 ME-MPRAGE weighted structural MRI scans were acquired and subsequently reviewed for IFs by radiologists. A neurologist reviewed radiological reports and categorised IFs according to their estimated clinical significance. IFs were observed on the scans of 95 (32%) participants but most IFs were either judged to be clinically non-significant (49%) or of unknown clinical significance (32%). Eighteen participants (6%) had clinically significant findings that required referral for further clinical management. Age was a significant predictor of having an IF, whereas a diagnosis of Parkinson's disease was a significant predictor of having a clinically significant IF.http://www.sciencedirect.com/science/article/pii/S266695602200054XIncidental findingsBrain MRISouth AfricaPTSDParkinson's diseaseNeuroimaging |
| spellingShingle | Chanellé Hendrikse Tina Malan Stéfan du Plessis Jonathan Carr Martin Kidd Robin Emsley Soraya Seedat Incidental neuroimaging findings in South African adult research participants with and without neuropsychiatric disorders NeuroImage: Reports Incidental findings Brain MRI South Africa PTSD Parkinson's disease Neuroimaging |
| title | Incidental neuroimaging findings in South African adult research participants with and without neuropsychiatric disorders |
| title_full | Incidental neuroimaging findings in South African adult research participants with and without neuropsychiatric disorders |
| title_fullStr | Incidental neuroimaging findings in South African adult research participants with and without neuropsychiatric disorders |
| title_full_unstemmed | Incidental neuroimaging findings in South African adult research participants with and without neuropsychiatric disorders |
| title_short | Incidental neuroimaging findings in South African adult research participants with and without neuropsychiatric disorders |
| title_sort | incidental neuroimaging findings in south african adult research participants with and without neuropsychiatric disorders |
| topic | Incidental findings Brain MRI South Africa PTSD Parkinson's disease Neuroimaging |
| url | http://www.sciencedirect.com/science/article/pii/S266695602200054X |
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