Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells
Cancer stem cells (CSCs) with self-renewal abilities endorse cellular heterogeneity, resulting in metastasis and recurrence. However, there are no promising therapeutics directed against CSCs. Herein, we found that miR-503-3p inhibited tumor growth via the regulation of CSC proliferation and self-re...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/4851949 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562500014440448 |
|---|---|
| author | Minkoo Seo Seung Min Kim Eun Young Woo Ki-Cheol Han Eun Joo Park Seongyeol Ko Eun wook Choi Mihue Jang |
| author_facet | Minkoo Seo Seung Min Kim Eun Young Woo Ki-Cheol Han Eun Joo Park Seongyeol Ko Eun wook Choi Mihue Jang |
| author_sort | Minkoo Seo |
| collection | DOAJ |
| description | Cancer stem cells (CSCs) with self-renewal abilities endorse cellular heterogeneity, resulting in metastasis and recurrence. However, there are no promising therapeutics directed against CSCs. Herein, we found that miR-503-3p inhibited tumor growth via the regulation of CSC proliferation and self-renewal. miR-503-3p, isolated from human adipose stem cell- (ASC-) derived exosomes, suppressed initiation and progression of CSCs as determined by anchorage-dependent (colony formation) and anchorage-independent (tumorsphere formation) assays. The expression of pluripotency genes was significantly decreased in miR-503-3p-treated CSCs. Furthermore, xenografts, which received miR-503-3p, exhibited remarkably reduced tumor growth in vivo. Thus, miR-503-3p may function as a stemness-attenuating factor via cell-to-cell communications. |
| format | Article |
| id | doaj-art-c265139ae51b40598ccab9fa61956b6c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-c265139ae51b40598ccab9fa61956b6c2025-02-03T01:22:33ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/48519494851949Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem CellsMinkoo Seo0Seung Min Kim1Eun Young Woo2Ki-Cheol Han3Eun Joo Park4Seongyeol Ko5Eun wook Choi6Mihue Jang7Prostemics Research Institute, Seongdong-gu, Seoul 135-010, Republic of KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seongbuk-Gu, Seoul 136-791, Republic of KoreaProstemics Research Institute, Seongdong-gu, Seoul 135-010, Republic of KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seongbuk-Gu, Seoul 136-791, Republic of KoreaProstemics Research Institute, Seongdong-gu, Seoul 135-010, Republic of KoreaProstemics Research Institute, Seongdong-gu, Seoul 135-010, Republic of KoreaProstemics Research Institute, Seongdong-gu, Seoul 135-010, Republic of KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seongbuk-Gu, Seoul 136-791, Republic of KoreaCancer stem cells (CSCs) with self-renewal abilities endorse cellular heterogeneity, resulting in metastasis and recurrence. However, there are no promising therapeutics directed against CSCs. Herein, we found that miR-503-3p inhibited tumor growth via the regulation of CSC proliferation and self-renewal. miR-503-3p, isolated from human adipose stem cell- (ASC-) derived exosomes, suppressed initiation and progression of CSCs as determined by anchorage-dependent (colony formation) and anchorage-independent (tumorsphere formation) assays. The expression of pluripotency genes was significantly decreased in miR-503-3p-treated CSCs. Furthermore, xenografts, which received miR-503-3p, exhibited remarkably reduced tumor growth in vivo. Thus, miR-503-3p may function as a stemness-attenuating factor via cell-to-cell communications.http://dx.doi.org/10.1155/2018/4851949 |
| spellingShingle | Minkoo Seo Seung Min Kim Eun Young Woo Ki-Cheol Han Eun Joo Park Seongyeol Ko Eun wook Choi Mihue Jang Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells Stem Cells International |
| title | Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells |
| title_full | Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells |
| title_fullStr | Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells |
| title_full_unstemmed | Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells |
| title_short | Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells |
| title_sort | stemness attenuating mir 503 3p as a paracrine factor to regulate growth of cancer stem cells |
| url | http://dx.doi.org/10.1155/2018/4851949 |
| work_keys_str_mv | AT minkooseo stemnessattenuatingmir5033pasaparacrinefactortoregulategrowthofcancerstemcells AT seungminkim stemnessattenuatingmir5033pasaparacrinefactortoregulategrowthofcancerstemcells AT eunyoungwoo stemnessattenuatingmir5033pasaparacrinefactortoregulategrowthofcancerstemcells AT kicheolhan stemnessattenuatingmir5033pasaparacrinefactortoregulategrowthofcancerstemcells AT eunjoopark stemnessattenuatingmir5033pasaparacrinefactortoregulategrowthofcancerstemcells AT seongyeolko stemnessattenuatingmir5033pasaparacrinefactortoregulategrowthofcancerstemcells AT eunwookchoi stemnessattenuatingmir5033pasaparacrinefactortoregulategrowthofcancerstemcells AT mihuejang stemnessattenuatingmir5033pasaparacrinefactortoregulategrowthofcancerstemcells |