One-step introduction of the hexafluoroisobutyl group, synthesis of (S)-5,5,5,5',5',5'-hexafluoroleucine, and its incorporation into peptides and proteins
The isobutyl motif is a highly prevalent functional group in medicinal chemistry, commonly present in numerous drugs and bioactive compounds. In biological systems, it notably corresponds to the side chain of the amino acid leucine. The replacement of this branched chain by the hexafluoroisobutyl gr...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Académie des sciences
2024-12-01
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| Series: | Comptes Rendus. Chimie |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.362/ |
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