Combination of αCD4 antibody and retinal antigen injection induces long-term disease control in autoimmune uveitis

Combination of αCD4 antibody and retinal antigen injection induces long-term disease control in autoimmune uveitis

IntroductionAutoimmune uveitis is a sight-threatening inflammatory eye disease driven by immune dysregulation. We previously introduced a therapeutic strategy involving the in vivo induction of retinal-antigen-specific regulatory T cells (Tregs) via αCD4 antibody injection followed by administration...

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Bibliographic Details
Main Authors: Dijie Qiao, Lu Zhang, Yajie Zhong, Dongmei Liu, Zilin Chen, Wai Po Chong, Jun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
autoimmune uveitis
immunotherapy
regulatory T cells (Treg)
long-term therapy
chronic inflammation
anti-CD4 antibody
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1636901/full
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