Can Islet Transplantation Possibly Reduce Mortality in Type 1 Diabetes
Islet transplantation (IT) is a successful natural cell therapy. But the benefits are known mostly to individuals with severe type 1 diabetes who undergo IT and the health care professionals that work to make the therapy available, reproducible, and safe. Data linking IT to overall survival in T1D m...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/09636897241312801 |
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| author | Jeffrey S. Isenberg Fouad Kandeel |
| author_facet | Jeffrey S. Isenberg Fouad Kandeel |
| author_sort | Jeffrey S. Isenberg |
| collection | DOAJ |
| description | Islet transplantation (IT) is a successful natural cell therapy. But the benefits are known mostly to individuals with severe type 1 diabetes who undergo IT and the health care professionals that work to make the therapy available, reproducible, and safe. Data linking IT to overall survival in T1D might alter this situation and frame the therapy in a more positive light. Recent analysis of mortality in several cohorts suggests that IT has possible survival benefits when used alone or in conjunction with renal transplantation. Multi-center prospective studies with long-term follow-up of individuals that receive stand-alone IT versus individuals who qualify for but do not undergo the procedure would seem reasonable to undertake to confirm an IT survival benefit. |
| format | Article |
| id | doaj-art-c2373cb6956d407ca6dc346b995d60bd |
| institution | Kabale University |
| issn | 1555-3892 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj-art-c2373cb6956d407ca6dc346b995d60bd2025-01-20T14:03:26ZengSAGE PublishingCell Transplantation1555-38922025-01-013410.1177/09636897241312801Can Islet Transplantation Possibly Reduce Mortality in Type 1 DiabetesJeffrey S. Isenberg0Fouad Kandeel1Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USADepartment of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USAIslet transplantation (IT) is a successful natural cell therapy. But the benefits are known mostly to individuals with severe type 1 diabetes who undergo IT and the health care professionals that work to make the therapy available, reproducible, and safe. Data linking IT to overall survival in T1D might alter this situation and frame the therapy in a more positive light. Recent analysis of mortality in several cohorts suggests that IT has possible survival benefits when used alone or in conjunction with renal transplantation. Multi-center prospective studies with long-term follow-up of individuals that receive stand-alone IT versus individuals who qualify for but do not undergo the procedure would seem reasonable to undertake to confirm an IT survival benefit.https://doi.org/10.1177/09636897241312801 |
| spellingShingle | Jeffrey S. Isenberg Fouad Kandeel Can Islet Transplantation Possibly Reduce Mortality in Type 1 Diabetes Cell Transplantation |
| title | Can Islet Transplantation Possibly Reduce Mortality in Type 1 Diabetes |
| title_full | Can Islet Transplantation Possibly Reduce Mortality in Type 1 Diabetes |
| title_fullStr | Can Islet Transplantation Possibly Reduce Mortality in Type 1 Diabetes |
| title_full_unstemmed | Can Islet Transplantation Possibly Reduce Mortality in Type 1 Diabetes |
| title_short | Can Islet Transplantation Possibly Reduce Mortality in Type 1 Diabetes |
| title_sort | can islet transplantation possibly reduce mortality in type 1 diabetes |
| url | https://doi.org/10.1177/09636897241312801 |
| work_keys_str_mv | AT jeffreysisenberg canislettransplantationpossiblyreducemortalityintype1diabetes AT fouadkandeel canislettransplantationpossiblyreducemortalityintype1diabetes |