Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep
<b>Aim:</b> In this study, it was aimed to determine the effect of IM marbofloxacin at different doses on biochemical and hematological parameters in healthy sheep.<p> <b>Materials and Methods:</b> The study was carried out on twenty four healthy Akkaraman rams (2-5 yea...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1202 |
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| Summary: | <b>Aim:</b> In this study, it was aimed to determine the effect of IM
marbofloxacin at different doses on biochemical and hematological
parameters in healthy sheep.<p>
<b>Materials and Methods:</b> The study was carried out on twenty
four healthy Akkaraman rams (2-5 years old) randomly selected
in four dose groups according to parallel design. There are six
animals in each dose group. There are six animals in each dose
group. Six animals in each group were injected with marbofloxacin
at the dose levels of 2, 4, 6 and 10 mg/kg, respectively, in
the semitendinosus muscle. Blood samples were collected using
a catheter placed in the left jugular vein at 0 (pre-treatment),
and 10. and 22 hours post-dosing. Biochemical parameters,
such as, albumin, alkaline phosphatase, alanine aminotransferase,
aspartate aminotransferase, cholesterol, triglyceride, total
protein, blood urea nitrogen, creatinine, and gamma-glutamyl
transferase were determined in autoanalyzer. Hematological
parameters, such as white blood cells, red blood cells, hemoglobin,
hematocrit, and platelet were measured in blood cell counter.<p>
<b>Results:</b> No significant differences in hematological and serum
biochemical parameters were found between the groups.<p>
<b>Conclusion:</b> These results indicate that the marbofloxacin after
a single intramuscular injection up to 10 mg/kg following IM
administration in sheep had no significant side effects on the
biochemical and hematological parameters measured. |
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| ISSN: | 1309-6958 2146-1953 |