Chitosan-MXene-gold-curcumin: quaternary nanohybrid platform: A Chemo/Photothermal onco-strategy for improved cancer therapy
In this study, MXene nanosheets were functionalized with gold nanoparticles and coated with chitosan to serve as a nanocarrier for curcumin. The aim was to develop a versatile multifunctional nanoplatform for effective cancer chemo/photothermal therapy. The biocompatible MXene (Ch@Au-MXNSs@Cur) exhi...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Carbohydrate Polymer Technologies and Applications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893925001331 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849744297595764736 |
|---|---|
| author | Nihal Saad Elbialy Mohamed Abdel Salam Noha Mohamed |
| author_facet | Nihal Saad Elbialy Mohamed Abdel Salam Noha Mohamed |
| author_sort | Nihal Saad Elbialy |
| collection | DOAJ |
| description | In this study, MXene nanosheets were functionalized with gold nanoparticles and coated with chitosan to serve as a nanocarrier for curcumin. The aim was to develop a versatile multifunctional nanoplatform for effective cancer chemo/photothermal therapy. The biocompatible MXene (Ch@Au-MXNSs@Cur) exhibited unique properties for curcumin delivery, including high drug-loading capacity and the ability to convert light into heat through surface plasmon resonance. Various techniques were employed to characterize the physicochemical properties of Ch@Au-MXNSs@Cur.The photothermal response of Ch@Au-MXNSs@Cur demonstrated a temperature increase exceeding 30 °C. In vitro studies against MCF-7 cancer cells revealed significantly enhanced therapeutic efficacy of the combined chemo/photothermal approach compared to PTT or chemotherapy alone. In a tumor-bearing mouse model, the nanotherapeutic system Ch@Au-MXNSs@Cur combined with a laser exhibited a significant antitumor effect against Ehrlich carcinoma. Moreover, the encapsulated polyphenolic curcumin played a crucial role in modulating p53 and VEGF levels, while also demonstrating strong free radical scavenging activity.Nanotoxicity assessment, based on liver and kidney function, yielded satisfactory results, confirming the safety of the nanoparticles. This promising outcome is attributed to the integration of gold nanoparticles and MXene, which not only enhanced the photothermal conversion efficiency but also facilitated curcumin delivery, synergistically supporting a combined Chemo/PTT therapeutic strategy. |
| format | Article |
| id | doaj-art-c217a23d2df847c0b146e47bccc8f45a |
| institution | DOAJ |
| issn | 2666-8939 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj-art-c217a23d2df847c0b146e47bccc8f45a2025-08-20T03:20:58ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392025-06-011010079510.1016/j.carpta.2025.100795Chitosan-MXene-gold-curcumin: quaternary nanohybrid platform: A Chemo/Photothermal onco-strategy for improved cancer therapyNihal Saad Elbialy0Mohamed Abdel Salam1Noha Mohamed2Department of Physics, Medical Physics Program, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Corresponding authors.Department of Chemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Biophysics, Faculty of Science, Cairo university, 12613 Giza, Egypt; Corresponding authors.In this study, MXene nanosheets were functionalized with gold nanoparticles and coated with chitosan to serve as a nanocarrier for curcumin. The aim was to develop a versatile multifunctional nanoplatform for effective cancer chemo/photothermal therapy. The biocompatible MXene (Ch@Au-MXNSs@Cur) exhibited unique properties for curcumin delivery, including high drug-loading capacity and the ability to convert light into heat through surface plasmon resonance. Various techniques were employed to characterize the physicochemical properties of Ch@Au-MXNSs@Cur.The photothermal response of Ch@Au-MXNSs@Cur demonstrated a temperature increase exceeding 30 °C. In vitro studies against MCF-7 cancer cells revealed significantly enhanced therapeutic efficacy of the combined chemo/photothermal approach compared to PTT or chemotherapy alone. In a tumor-bearing mouse model, the nanotherapeutic system Ch@Au-MXNSs@Cur combined with a laser exhibited a significant antitumor effect against Ehrlich carcinoma. Moreover, the encapsulated polyphenolic curcumin played a crucial role in modulating p53 and VEGF levels, while also demonstrating strong free radical scavenging activity.Nanotoxicity assessment, based on liver and kidney function, yielded satisfactory results, confirming the safety of the nanoparticles. This promising outcome is attributed to the integration of gold nanoparticles and MXene, which not only enhanced the photothermal conversion efficiency but also facilitated curcumin delivery, synergistically supporting a combined Chemo/PTT therapeutic strategy.http://www.sciencedirect.com/science/article/pii/S2666893925001331Nanohybrid “MXene-gold-curcumin-chitosan”Chemo/Photothermal therapyEhrlich carcinoma |
| spellingShingle | Nihal Saad Elbialy Mohamed Abdel Salam Noha Mohamed Chitosan-MXene-gold-curcumin: quaternary nanohybrid platform: A Chemo/Photothermal onco-strategy for improved cancer therapy Carbohydrate Polymer Technologies and Applications Nanohybrid “MXene-gold-curcumin-chitosan” Chemo/Photothermal therapy Ehrlich carcinoma |
| title | Chitosan-MXene-gold-curcumin: quaternary nanohybrid platform: A Chemo/Photothermal onco-strategy for improved cancer therapy |
| title_full | Chitosan-MXene-gold-curcumin: quaternary nanohybrid platform: A Chemo/Photothermal onco-strategy for improved cancer therapy |
| title_fullStr | Chitosan-MXene-gold-curcumin: quaternary nanohybrid platform: A Chemo/Photothermal onco-strategy for improved cancer therapy |
| title_full_unstemmed | Chitosan-MXene-gold-curcumin: quaternary nanohybrid platform: A Chemo/Photothermal onco-strategy for improved cancer therapy |
| title_short | Chitosan-MXene-gold-curcumin: quaternary nanohybrid platform: A Chemo/Photothermal onco-strategy for improved cancer therapy |
| title_sort | chitosan mxene gold curcumin quaternary nanohybrid platform a chemo photothermal onco strategy for improved cancer therapy |
| topic | Nanohybrid “MXene-gold-curcumin-chitosan” Chemo/Photothermal therapy Ehrlich carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2666893925001331 |
| work_keys_str_mv | AT nihalsaadelbialy chitosanmxenegoldcurcuminquaternarynanohybridplatformachemophotothermaloncostrategyforimprovedcancertherapy AT mohamedabdelsalam chitosanmxenegoldcurcuminquaternarynanohybridplatformachemophotothermaloncostrategyforimprovedcancertherapy AT nohamohamed chitosanmxenegoldcurcuminquaternarynanohybridplatformachemophotothermaloncostrategyforimprovedcancertherapy |