Genetics of hyperuricemia and gout: Insights from recent genome-wide association studies and Mendelian randomization studies
Gout is the most common form of inflammatory arthritis in adults. Elevation serum uric acid (SUA) concentration is known to be the key to gout pathogenesis. Since the first genome-wide association study (GWAS) for SUA was performed in 2007, the number of gene loci known to be associated with hyperur...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Tzu Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=3;spage=261;epage=269;aulast= |
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| author | Yu-Lin Ko |
| author_facet | Yu-Lin Ko |
| author_sort | Yu-Lin Ko |
| collection | DOAJ |
| description | Gout is the most common form of inflammatory arthritis in adults. Elevation serum uric acid (SUA) concentration is known to be the key to gout pathogenesis. Since the first genome-wide association study (GWAS) for SUA was performed in 2007, the number of gene loci known to be associated with hyperuricemia and gout has grown rapidly. GWASs and Mendelian randomization studies have also reported numerous novel results regarding the genetics of hyperuricemia and gout since 2018. We concisely review recent advances in scholarship on the effects of genetics on hyperuricemia and gout risk. We also review data from genetic association studies in Taiwan and perform GWASs of SUA levels among Taiwan Biobank participants. |
| format | Article |
| id | doaj-art-c2056072ebfb4b379b33d274feac13d3 |
| institution | OA Journals |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-c2056072ebfb4b379b33d274feac13d32025-08-20T02:02:33ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562022-01-0134326126910.4103/tcmj.tcmj_117_21Genetics of hyperuricemia and gout: Insights from recent genome-wide association studies and Mendelian randomization studiesYu-Lin KoGout is the most common form of inflammatory arthritis in adults. Elevation serum uric acid (SUA) concentration is known to be the key to gout pathogenesis. Since the first genome-wide association study (GWAS) for SUA was performed in 2007, the number of gene loci known to be associated with hyperuricemia and gout has grown rapidly. GWASs and Mendelian randomization studies have also reported numerous novel results regarding the genetics of hyperuricemia and gout since 2018. We concisely review recent advances in scholarship on the effects of genetics on hyperuricemia and gout risk. We also review data from genetic association studies in Taiwan and perform GWASs of SUA levels among Taiwan Biobank participants.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=3;spage=261;epage=269;aulast=geneticsgenome-wide association studygouthyperuricemiamendelian randomization study |
| spellingShingle | Yu-Lin Ko Genetics of hyperuricemia and gout: Insights from recent genome-wide association studies and Mendelian randomization studies Tzu Chi Medical Journal genetics genome-wide association study gout hyperuricemia mendelian randomization study |
| title | Genetics of hyperuricemia and gout: Insights from recent genome-wide association studies and Mendelian randomization studies |
| title_full | Genetics of hyperuricemia and gout: Insights from recent genome-wide association studies and Mendelian randomization studies |
| title_fullStr | Genetics of hyperuricemia and gout: Insights from recent genome-wide association studies and Mendelian randomization studies |
| title_full_unstemmed | Genetics of hyperuricemia and gout: Insights from recent genome-wide association studies and Mendelian randomization studies |
| title_short | Genetics of hyperuricemia and gout: Insights from recent genome-wide association studies and Mendelian randomization studies |
| title_sort | genetics of hyperuricemia and gout insights from recent genome wide association studies and mendelian randomization studies |
| topic | genetics genome-wide association study gout hyperuricemia mendelian randomization study |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=3;spage=261;epage=269;aulast= |
| work_keys_str_mv | AT yulinko geneticsofhyperuricemiaandgoutinsightsfromrecentgenomewideassociationstudiesandmendelianrandomizationstudies |