Long non-coding RNA DANCR, a prognostic indicator, promotes cell growth and tumorigenicity in gastric cancer
Gastric cancer remains the third leading cause of cancer-related mortality worldwide, and proliferation of gastric cancer represents the major reason for its poor prognosis. Recent evidence indicates that long non-coding RNAs play crucial roles in development and progression of gastric cancer. Long...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-05-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317699798 |
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| author | Yan-Ping Hao Jing-Hui Qiu Dong-Bo Zhang Cheng-Gong Yu |
| author_facet | Yan-Ping Hao Jing-Hui Qiu Dong-Bo Zhang Cheng-Gong Yu |
| author_sort | Yan-Ping Hao |
| collection | DOAJ |
| description | Gastric cancer remains the third leading cause of cancer-related mortality worldwide, and proliferation of gastric cancer represents the major reason for its poor prognosis. Recent evidence indicates that long non-coding RNAs play crucial roles in development and progression of gastric cancer. Long non-coding RNA differentiation antagonizing non-protein coding RNA is upregulated in hepatic cell carcinoma, but the role of lncRNA differentiation antagonizing non-protein coding RNA in gastric cancer has not been explored. In this article, we found that differentiation antagonizing non-protein coding RNA is also upregulated in gastric cancer. Experiments revealed that silencing differentiation antagonizing non-protein coding RNA significantly inhibited gastric cancer cell proliferation in vitro and in vivo. Overexpression of differentiation antagonizing non-protein coding RNA notably increases gastric cancer cell proliferation. From RNA-seq and gene ontology annotations, we found that differentiation antagonizing non-protein coding RNA influences the gene expression programs in cell metabolic and cycle process. Taken together, our findings suggest that the long non-coding RNA differentiation antagonizing non-protein coding RNA promotes the proliferation of gastric cancer and is a potential prognostic biomarker and therapeutic target in gastric cancer. |
| format | Article |
| id | doaj-art-c1ff69fc064d48c1b94c27ccfe5abbc9 |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-c1ff69fc064d48c1b94c27ccfe5abbc92025-08-20T03:57:39ZengSAGE PublishingTumor Biology1423-03802017-05-013910.1177/1010428317699798Long non-coding RNA DANCR, a prognostic indicator, promotes cell growth and tumorigenicity in gastric cancerYan-Ping Hao0Jing-Hui Qiu1Dong-Bo Zhang2Cheng-Gong Yu3Department of Gastroenterology, The First People’s Hospital of Yancheng, Yancheng, Jiangsu, ChinaDepartment of Anesthesiology, The Third People’s Hospital of Yancheng, Yancheng, Jiangsu, ChinaDepartment of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Clinical college of Nanjing Medical University, Nanjing, ChinaGastric cancer remains the third leading cause of cancer-related mortality worldwide, and proliferation of gastric cancer represents the major reason for its poor prognosis. Recent evidence indicates that long non-coding RNAs play crucial roles in development and progression of gastric cancer. Long non-coding RNA differentiation antagonizing non-protein coding RNA is upregulated in hepatic cell carcinoma, but the role of lncRNA differentiation antagonizing non-protein coding RNA in gastric cancer has not been explored. In this article, we found that differentiation antagonizing non-protein coding RNA is also upregulated in gastric cancer. Experiments revealed that silencing differentiation antagonizing non-protein coding RNA significantly inhibited gastric cancer cell proliferation in vitro and in vivo. Overexpression of differentiation antagonizing non-protein coding RNA notably increases gastric cancer cell proliferation. From RNA-seq and gene ontology annotations, we found that differentiation antagonizing non-protein coding RNA influences the gene expression programs in cell metabolic and cycle process. Taken together, our findings suggest that the long non-coding RNA differentiation antagonizing non-protein coding RNA promotes the proliferation of gastric cancer and is a potential prognostic biomarker and therapeutic target in gastric cancer.https://doi.org/10.1177/1010428317699798 |
| spellingShingle | Yan-Ping Hao Jing-Hui Qiu Dong-Bo Zhang Cheng-Gong Yu Long non-coding RNA DANCR, a prognostic indicator, promotes cell growth and tumorigenicity in gastric cancer Tumor Biology |
| title | Long non-coding RNA DANCR, a prognostic indicator, promotes cell growth and tumorigenicity in gastric cancer |
| title_full | Long non-coding RNA DANCR, a prognostic indicator, promotes cell growth and tumorigenicity in gastric cancer |
| title_fullStr | Long non-coding RNA DANCR, a prognostic indicator, promotes cell growth and tumorigenicity in gastric cancer |
| title_full_unstemmed | Long non-coding RNA DANCR, a prognostic indicator, promotes cell growth and tumorigenicity in gastric cancer |
| title_short | Long non-coding RNA DANCR, a prognostic indicator, promotes cell growth and tumorigenicity in gastric cancer |
| title_sort | long non coding rna dancr a prognostic indicator promotes cell growth and tumorigenicity in gastric cancer |
| url | https://doi.org/10.1177/1010428317699798 |
| work_keys_str_mv | AT yanpinghao longnoncodingrnadancraprognosticindicatorpromotescellgrowthandtumorigenicityingastriccancer AT jinghuiqiu longnoncodingrnadancraprognosticindicatorpromotescellgrowthandtumorigenicityingastriccancer AT dongbozhang longnoncodingrnadancraprognosticindicatorpromotescellgrowthandtumorigenicityingastriccancer AT chenggongyu longnoncodingrnadancraprognosticindicatorpromotescellgrowthandtumorigenicityingastriccancer |