Diffuse Panbronchiolitis in a Caucasian Man in Canada
Diffuse panbronchiolitis (DPB) is a rare, chronic bronchiolar disease in non-Asian populations and is therefore commonly overlooked in Western countries. It usually affects nonsmokers and manifests as persistent air flow obstruction, chronic cough and interstitial nodular opacities. Untreated, the p...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2003/786531 |
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| author | Alessandra Sandrini MS Balter Kenneth R Chapman |
| author_facet | Alessandra Sandrini MS Balter Kenneth R Chapman |
| author_sort | Alessandra Sandrini |
| collection | DOAJ |
| description | Diffuse panbronchiolitis (DPB) is a rare, chronic bronchiolar disease in non-Asian populations and is therefore commonly overlooked in Western countries. It usually affects nonsmokers and manifests as persistent air flow obstruction, chronic cough and interstitial nodular opacities. Untreated, the prognosis is poor. In this report the authors describe a Caucasian man of Canadian descent who presented with progressive clinical and lung function impairment despite three years of bronchodilator and corticosteroid treatment with presumed asthma. His chest computed tomography scan showed diffuse centrilobular opacities. Lung biopsy revealed chronic bronchiolitis characterized by infiltration of lymphocytes, plasma cells and foam cells in respiratory and terminal bronchioles, compatible with a diagnosis of DPB. After two months of therapy with clarithromycin, the patient had already shown improvement. Physicians should be aware that DPB may occur in Western countries, and that DPB should be considered in the differential diagnosis of patients with persistent air flow obstruction and nodular shadows on chest radiograms. |
| format | Article |
| id | doaj-art-c1f274cab3f24ac0b91a7e1e764862e3 |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-c1f274cab3f24ac0b91a7e1e764862e32025-02-03T01:00:17ZengWileyCanadian Respiratory Journal1198-22412003-01-0110844945110.1155/2003/786531Diffuse Panbronchiolitis in a Caucasian Man in CanadaAlessandra Sandrini0MS Balter1Kenneth R Chapman2Division of Respiratory Medicine, Department of Medicine, University of Toronto, CanadaDivision of Respiratory Medicine, Department of Medicine, University of Toronto, CanadaDivision of Respiratory Medicine, Department of Medicine, University of Toronto, CanadaDiffuse panbronchiolitis (DPB) is a rare, chronic bronchiolar disease in non-Asian populations and is therefore commonly overlooked in Western countries. It usually affects nonsmokers and manifests as persistent air flow obstruction, chronic cough and interstitial nodular opacities. Untreated, the prognosis is poor. In this report the authors describe a Caucasian man of Canadian descent who presented with progressive clinical and lung function impairment despite three years of bronchodilator and corticosteroid treatment with presumed asthma. His chest computed tomography scan showed diffuse centrilobular opacities. Lung biopsy revealed chronic bronchiolitis characterized by infiltration of lymphocytes, plasma cells and foam cells in respiratory and terminal bronchioles, compatible with a diagnosis of DPB. After two months of therapy with clarithromycin, the patient had already shown improvement. Physicians should be aware that DPB may occur in Western countries, and that DPB should be considered in the differential diagnosis of patients with persistent air flow obstruction and nodular shadows on chest radiograms.http://dx.doi.org/10.1155/2003/786531 |
| spellingShingle | Alessandra Sandrini MS Balter Kenneth R Chapman Diffuse Panbronchiolitis in a Caucasian Man in Canada Canadian Respiratory Journal |
| title | Diffuse Panbronchiolitis in a Caucasian Man in Canada |
| title_full | Diffuse Panbronchiolitis in a Caucasian Man in Canada |
| title_fullStr | Diffuse Panbronchiolitis in a Caucasian Man in Canada |
| title_full_unstemmed | Diffuse Panbronchiolitis in a Caucasian Man in Canada |
| title_short | Diffuse Panbronchiolitis in a Caucasian Man in Canada |
| title_sort | diffuse panbronchiolitis in a caucasian man in canada |
| url | http://dx.doi.org/10.1155/2003/786531 |
| work_keys_str_mv | AT alessandrasandrini diffusepanbronchiolitisinacaucasianmanincanada AT msbalter diffusepanbronchiolitisinacaucasianmanincanada AT kennethrchapman diffusepanbronchiolitisinacaucasianmanincanada |