Assessment of School Readiness in Chronic Cholestatic Liver Disease: A Pilot Study Examining Children with and without Liver Transplantation
Background. Assessment of school readiness evaluates physical, social-emotional, and neuropsychological domains essential for educational success. Cognitive testing of preschool aged children with chronic liver disease may guide more timely interventions and focused efforts by health care providers....
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2017/9873945 |
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| author | Anna Gold Alaine Rogers Elizabeth Cruchley Stephanie Rankin Arpita Parmar Binita M. Kamath Yaron Avitzur Vicky Lee Ng |
| author_facet | Anna Gold Alaine Rogers Elizabeth Cruchley Stephanie Rankin Arpita Parmar Binita M. Kamath Yaron Avitzur Vicky Lee Ng |
| author_sort | Anna Gold |
| collection | DOAJ |
| description | Background. Assessment of school readiness evaluates physical, social-emotional, and neuropsychological domains essential for educational success. Cognitive testing of preschool aged children with chronic liver disease may guide more timely interventions and focused efforts by health care providers. Patients and Methods. Children with chronic cholestatic liver disease diagnosed as an infant and still with their native liver (NL) and children who received a liver transplant (LT) before age of 2 years underwent testing with a battery of well-validated pediatric psychometric measures. Results. Eighteen (13 LT, 5 NL) patients (median age of 4.45 and 4.05 years, resp.) were tested. Median Full-Scale IQ was 98 (range 102–116) for LT and 116 [(range 90–106), p=0.35, NS] for NL subjects. LT recipients had significantly greater visual based difficulties, poorer caregiver rated daily living skills (p=0.04), and higher levels of executive function based difficulties (e.g., inattention, inhibition). Conclusion. This pilot study highlights the risk of neuropsychological difficulties in early school age children who were under 2 years of age at time of LT. Comprehensive early school age assessment should integrate psychometric measures to identify children at greatest risk, thus allowing for proactive educational intervention. |
| format | Article |
| id | doaj-art-c1ee7618154544ee901994d648268752 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-c1ee7618154544ee901994d6482687522025-02-03T05:46:46ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972017-01-01201710.1155/2017/98739459873945Assessment of School Readiness in Chronic Cholestatic Liver Disease: A Pilot Study Examining Children with and without Liver TransplantationAnna Gold0Alaine Rogers1Elizabeth Cruchley2Stephanie Rankin3Arpita Parmar4Binita M. Kamath5Yaron Avitzur6Vicky Lee Ng7Transplant and Regenerative Medicine Centre, Hospital for Sick Children, Toronto, ON, CanadaDepartment of Rehabilitation, Hospital for Sick Children, Toronto, ON, CanadaTransplant and Regenerative Medicine Centre, Hospital for Sick Children, Toronto, ON, CanadaTransplant and Regenerative Medicine Centre, Hospital for Sick Children, Toronto, ON, CanadaTransplant and Regenerative Medicine Centre, Hospital for Sick Children, Toronto, ON, CanadaTransplant and Regenerative Medicine Centre, Hospital for Sick Children, Toronto, ON, CanadaTransplant and Regenerative Medicine Centre, Hospital for Sick Children, Toronto, ON, CanadaTransplant and Regenerative Medicine Centre, Hospital for Sick Children, Toronto, ON, CanadaBackground. Assessment of school readiness evaluates physical, social-emotional, and neuropsychological domains essential for educational success. Cognitive testing of preschool aged children with chronic liver disease may guide more timely interventions and focused efforts by health care providers. Patients and Methods. Children with chronic cholestatic liver disease diagnosed as an infant and still with their native liver (NL) and children who received a liver transplant (LT) before age of 2 years underwent testing with a battery of well-validated pediatric psychometric measures. Results. Eighteen (13 LT, 5 NL) patients (median age of 4.45 and 4.05 years, resp.) were tested. Median Full-Scale IQ was 98 (range 102–116) for LT and 116 [(range 90–106), p=0.35, NS] for NL subjects. LT recipients had significantly greater visual based difficulties, poorer caregiver rated daily living skills (p=0.04), and higher levels of executive function based difficulties (e.g., inattention, inhibition). Conclusion. This pilot study highlights the risk of neuropsychological difficulties in early school age children who were under 2 years of age at time of LT. Comprehensive early school age assessment should integrate psychometric measures to identify children at greatest risk, thus allowing for proactive educational intervention.http://dx.doi.org/10.1155/2017/9873945 |
| spellingShingle | Anna Gold Alaine Rogers Elizabeth Cruchley Stephanie Rankin Arpita Parmar Binita M. Kamath Yaron Avitzur Vicky Lee Ng Assessment of School Readiness in Chronic Cholestatic Liver Disease: A Pilot Study Examining Children with and without Liver Transplantation Canadian Journal of Gastroenterology and Hepatology |
| title | Assessment of School Readiness in Chronic Cholestatic Liver Disease: A Pilot Study Examining Children with and without Liver Transplantation |
| title_full | Assessment of School Readiness in Chronic Cholestatic Liver Disease: A Pilot Study Examining Children with and without Liver Transplantation |
| title_fullStr | Assessment of School Readiness in Chronic Cholestatic Liver Disease: A Pilot Study Examining Children with and without Liver Transplantation |
| title_full_unstemmed | Assessment of School Readiness in Chronic Cholestatic Liver Disease: A Pilot Study Examining Children with and without Liver Transplantation |
| title_short | Assessment of School Readiness in Chronic Cholestatic Liver Disease: A Pilot Study Examining Children with and without Liver Transplantation |
| title_sort | assessment of school readiness in chronic cholestatic liver disease a pilot study examining children with and without liver transplantation |
| url | http://dx.doi.org/10.1155/2017/9873945 |
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