A Randomized Controlled Trial Evaluating a Low-Volume PEG Solution Plus Ascorbic Acid versus Standard PEG Solution in Bowel Preparation for Colonoscopy
Evaluation of polyethylene glycol electrolyte lavage solution containing ascorbic acid (PEG-ASC) has been controversial in the point of its hyperosmolarity, especially in old population. So we therefore designed the present study to compare the efficacy, acceptability, tolerability, and safety of 1....
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/326581 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567682990342144 |
|---|---|
| author | Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Nobumasa Mizuno Kazuo Hara Susumu Hijioka Hiroshi Imaoka Takamitsu Sato Tatsuji Yogi Hideharu Tsutsumi Toshihisa Fujiyoshi Nobuhiro Hieda Nozomi Okuno Tsukasa Yoshida Vikram Bhatia Yasushi Yatabe Kenji Yamao Yasumasa Niwa |
| author_facet | Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Nobumasa Mizuno Kazuo Hara Susumu Hijioka Hiroshi Imaoka Takamitsu Sato Tatsuji Yogi Hideharu Tsutsumi Toshihisa Fujiyoshi Nobuhiro Hieda Nozomi Okuno Tsukasa Yoshida Vikram Bhatia Yasushi Yatabe Kenji Yamao Yasumasa Niwa |
| author_sort | Masahiro Tajika |
| collection | DOAJ |
| description | Evaluation of polyethylene glycol electrolyte lavage solution containing ascorbic acid (PEG-ASC) has been controversial in the point of its hyperosmolarity, especially in old population. So we therefore designed the present study to compare the efficacy, acceptability, tolerability, and safety of 1.5 L PEG+ASC and 2 L standard PEG electrolyte solution (PEG-ELS), not only in the general population, but also in patients of advanced age. Randomization was stratified by age (<70 years or 70> years), and hematological and biochemical parameters were compared in each age group, especially with respect to the safety profile of each regimen. As a result, the 1.5-L PEG-ASC regimen had higher patient acceptability than the 2-L PEG-ELS regimen. Tolerability, bowel cleansing, and safety were similar between regimens. However, we demonstrated significant statistical changes in the hematological and biochemical parameters after taking bowel preparation solutions, not only in the PEG+ASC group, but also in the PEG-ELS group. No significant differences in the safety profile were found between subjects aged less than 70 years and those aged 70 years or more; nevertheless, regardless of age, proper hydration is needed throughout the bowel preparation process. |
| format | Article |
| id | doaj-art-c1ed241f317748d0b339b7b6c3a1dc15 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-c1ed241f317748d0b339b7b6c3a1dc152025-02-03T01:00:55ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/326581326581A Randomized Controlled Trial Evaluating a Low-Volume PEG Solution Plus Ascorbic Acid versus Standard PEG Solution in Bowel Preparation for ColonoscopyMasahiro Tajika0Tsutomu Tanaka1Makoto Ishihara2Nobumasa Mizuno3Kazuo Hara4Susumu Hijioka5Hiroshi Imaoka6Takamitsu Sato7Tatsuji Yogi8Hideharu Tsutsumi9Toshihisa Fujiyoshi10Nobuhiro Hieda11Nozomi Okuno12Tsukasa Yoshida13Vikram Bhatia14Yasushi Yatabe15Kenji Yamao16Yasumasa Niwa17Department of Endoscopy, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Endoscopy, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Endoscopy, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Medical Hepatology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi, Delhi 110070, IndiaDepartment of Pathology and Molecular Diagnosis, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanDepartment of Endoscopy, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanEvaluation of polyethylene glycol electrolyte lavage solution containing ascorbic acid (PEG-ASC) has been controversial in the point of its hyperosmolarity, especially in old population. So we therefore designed the present study to compare the efficacy, acceptability, tolerability, and safety of 1.5 L PEG+ASC and 2 L standard PEG electrolyte solution (PEG-ELS), not only in the general population, but also in patients of advanced age. Randomization was stratified by age (<70 years or 70> years), and hematological and biochemical parameters were compared in each age group, especially with respect to the safety profile of each regimen. As a result, the 1.5-L PEG-ASC regimen had higher patient acceptability than the 2-L PEG-ELS regimen. Tolerability, bowel cleansing, and safety were similar between regimens. However, we demonstrated significant statistical changes in the hematological and biochemical parameters after taking bowel preparation solutions, not only in the PEG+ASC group, but also in the PEG-ELS group. No significant differences in the safety profile were found between subjects aged less than 70 years and those aged 70 years or more; nevertheless, regardless of age, proper hydration is needed throughout the bowel preparation process.http://dx.doi.org/10.1155/2015/326581 |
| spellingShingle | Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Nobumasa Mizuno Kazuo Hara Susumu Hijioka Hiroshi Imaoka Takamitsu Sato Tatsuji Yogi Hideharu Tsutsumi Toshihisa Fujiyoshi Nobuhiro Hieda Nozomi Okuno Tsukasa Yoshida Vikram Bhatia Yasushi Yatabe Kenji Yamao Yasumasa Niwa A Randomized Controlled Trial Evaluating a Low-Volume PEG Solution Plus Ascorbic Acid versus Standard PEG Solution in Bowel Preparation for Colonoscopy Gastroenterology Research and Practice |
| title | A Randomized Controlled Trial Evaluating a Low-Volume PEG Solution Plus Ascorbic Acid versus Standard PEG Solution in Bowel Preparation for Colonoscopy |
| title_full | A Randomized Controlled Trial Evaluating a Low-Volume PEG Solution Plus Ascorbic Acid versus Standard PEG Solution in Bowel Preparation for Colonoscopy |
| title_fullStr | A Randomized Controlled Trial Evaluating a Low-Volume PEG Solution Plus Ascorbic Acid versus Standard PEG Solution in Bowel Preparation for Colonoscopy |
| title_full_unstemmed | A Randomized Controlled Trial Evaluating a Low-Volume PEG Solution Plus Ascorbic Acid versus Standard PEG Solution in Bowel Preparation for Colonoscopy |
| title_short | A Randomized Controlled Trial Evaluating a Low-Volume PEG Solution Plus Ascorbic Acid versus Standard PEG Solution in Bowel Preparation for Colonoscopy |
| title_sort | randomized controlled trial evaluating a low volume peg solution plus ascorbic acid versus standard peg solution in bowel preparation for colonoscopy |
| url | http://dx.doi.org/10.1155/2015/326581 |
| work_keys_str_mv | AT masahirotajika arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT tsutomutanaka arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT makotoishihara arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT nobumasamizuno arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT kazuohara arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT susumuhijioka arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT hiroshiimaoka arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT takamitsusato arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT tatsujiyogi arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT hideharutsutsumi arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT toshihisafujiyoshi arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT nobuhirohieda arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT nozomiokuno arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT tsukasayoshida arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT vikrambhatia arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT yasushiyatabe arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT kenjiyamao arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT yasumasaniwa arandomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT masahirotajika randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT tsutomutanaka randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT makotoishihara randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT nobumasamizuno randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT kazuohara randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT susumuhijioka randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT hiroshiimaoka randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT takamitsusato randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT tatsujiyogi randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT hideharutsutsumi randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT toshihisafujiyoshi randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT nobuhirohieda randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT nozomiokuno randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT tsukasayoshida randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT vikrambhatia randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT yasushiyatabe randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT kenjiyamao randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy AT yasumasaniwa randomizedcontrolledtrialevaluatingalowvolumepegsolutionplusascorbicacidversusstandardpegsolutioninbowelpreparationforcolonoscopy |