Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report
IntroductionBrodifacoum is a highly potent superwarfarin rodenticide that leads to coagulopathy. Although the effect of warfarin during pregnancy is well understood, reports on superwarfarin poisoning, like brodifacoum, during pregnancy are scarce.Case PresentationWe report a case involving a woman...
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Frontiers Media S.A.
2024-11-01
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| author | Yanxi Jia Yanxi Jia Yongchi Zhan Yongchi Zhan Guiqiong Huang Guiqiong Huang Chunyan Deng Chunyan Deng Haiyan Yu Haiyan Yu |
| author_facet | Yanxi Jia Yanxi Jia Yongchi Zhan Yongchi Zhan Guiqiong Huang Guiqiong Huang Chunyan Deng Chunyan Deng Haiyan Yu Haiyan Yu |
| author_sort | Yanxi Jia |
| collection | DOAJ |
| description | IntroductionBrodifacoum is a highly potent superwarfarin rodenticide that leads to coagulopathy. Although the effect of warfarin during pregnancy is well understood, reports on superwarfarin poisoning, like brodifacoum, during pregnancy are scarce.Case PresentationWe report a case involving a woman with a singleton pregnancy who experienced sudden nasal hemorrhage accompanied by hematuria at 34 weeks and 3 days of gestation, with no apparent etiology. It was ultimately diagnosed as acquired coagulopathy resulting from brodifacoum poisoning. Fetal ultrasonography revealed significant intracranial hemorrhage, leading to intrauterine fetal demise and subsequent pregnancy termination. Following the correction of the patient’s coagulation profile through intravenous and oral administration of vitamin K1, tailored to the serum levels of brodifacoum, diligent monitoring confirmed that the patient was in stable condition.ConclusionThe primary hazard associated with the ingestion of brodifacoum is hemorrhage, with clinical presentations varying from asymptomatic cases to overt bleeding, which may present as hematuria, epistaxis, menometrorrhagia, and intracranial hemorrhage. Therefore, the diagnosis and management of this type of poisoning pose significant challenges. Prompt recognition and ongoing care for pregnant individuals affected by rodenticide toxicity are crucial for optimizing maternal health outcomes. |
| format | Article |
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| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-c1e52c5dcf724f9aba2fa2c98b3e96ff2025-08-20T02:48:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-11-011510.3389/fphar.2024.15025961502596Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case reportYanxi Jia0Yanxi Jia1Yongchi Zhan2Yongchi Zhan3Guiqiong Huang4Guiqiong Huang5Chunyan Deng6Chunyan Deng7Haiyan Yu8Haiyan Yu9Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaIntroductionBrodifacoum is a highly potent superwarfarin rodenticide that leads to coagulopathy. Although the effect of warfarin during pregnancy is well understood, reports on superwarfarin poisoning, like brodifacoum, during pregnancy are scarce.Case PresentationWe report a case involving a woman with a singleton pregnancy who experienced sudden nasal hemorrhage accompanied by hematuria at 34 weeks and 3 days of gestation, with no apparent etiology. It was ultimately diagnosed as acquired coagulopathy resulting from brodifacoum poisoning. Fetal ultrasonography revealed significant intracranial hemorrhage, leading to intrauterine fetal demise and subsequent pregnancy termination. Following the correction of the patient’s coagulation profile through intravenous and oral administration of vitamin K1, tailored to the serum levels of brodifacoum, diligent monitoring confirmed that the patient was in stable condition.ConclusionThe primary hazard associated with the ingestion of brodifacoum is hemorrhage, with clinical presentations varying from asymptomatic cases to overt bleeding, which may present as hematuria, epistaxis, menometrorrhagia, and intracranial hemorrhage. Therefore, the diagnosis and management of this type of poisoning pose significant challenges. Prompt recognition and ongoing care for pregnant individuals affected by rodenticide toxicity are crucial for optimizing maternal health outcomes.https://www.frontiersin.org/articles/10.3389/fphar.2024.1502596/fullbrodifacoumlong-acting anticoagulant rodenticidesvitamin Kpregnancycoagulation dysfunctioncase report |
| spellingShingle | Yanxi Jia Yanxi Jia Yongchi Zhan Yongchi Zhan Guiqiong Huang Guiqiong Huang Chunyan Deng Chunyan Deng Haiyan Yu Haiyan Yu Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report Frontiers in Pharmacology brodifacoum long-acting anticoagulant rodenticides vitamin K pregnancy coagulation dysfunction case report |
| title | Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report |
| title_full | Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report |
| title_fullStr | Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report |
| title_full_unstemmed | Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report |
| title_short | Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report |
| title_sort | acute long acting anticoagulant rodenticide poisoning in pregnancy a case report |
| topic | brodifacoum long-acting anticoagulant rodenticides vitamin K pregnancy coagulation dysfunction case report |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1502596/full |
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