Fear extinction retention in children, adolescents, and adults
Past results suggest that fear extinction and the return of extinguished fear are compromised in adolescents. However, findings have been inconclusive as there is a lack of fear extinction and extinction retention studies including children, adolescents and adults. In the present study, 36 children...
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Elsevier
2025-01-01
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| Series: | Developmental Cognitive Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929325000040 |
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| author | Ebba Widegren Johan Vegelius Matilda A. Frick Ashika A. Roy Stefan Möller Johan Lundin Kleberg Johanna Motilla Hoppe Olof Hjorth David Fällmar Daniel S. Pine Karin Brocki Malin Gingnell Andreas Frick |
| author_facet | Ebba Widegren Johan Vegelius Matilda A. Frick Ashika A. Roy Stefan Möller Johan Lundin Kleberg Johanna Motilla Hoppe Olof Hjorth David Fällmar Daniel S. Pine Karin Brocki Malin Gingnell Andreas Frick |
| author_sort | Ebba Widegren |
| collection | DOAJ |
| description | Past results suggest that fear extinction and the return of extinguished fear are compromised in adolescents. However, findings have been inconclusive as there is a lack of fear extinction and extinction retention studies including children, adolescents and adults. In the present study, 36 children (6–9 years), 40 adolescents (13–17 years) and 44 adults (30–40 years), underwent a two-day fear conditioning task. Habituation, acquisition, and extinction were performed on the first day and an extinction retention test > 24 h later. Skin conductance responses were recorded during all phases of fear conditioning and functional magnetic resonance imaging (fMRI) was conducted during the fear retention test. All groups acquired and extinguished fear as measured with SCR, with no group differences in SCR during extinction retention. The groups had largely similar neural fear responses during the retention test, apart from adolescents displaying stronger amygdala fear response than children, with no differences between adolescents and adults. The findings do not support an adolescent extinction dip, and there was only marginal evidence of progressive changes in fear conditioning across development. In contrast to findings in rodents, fear conditioning in humans may elicit similar physiological responses and recruit similar neural networks from childhood to adulthood. |
| format | Article |
| id | doaj-art-c1e2aa9a6e6a4532b568b23d242db457 |
| institution | Kabale University |
| issn | 1878-9293 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj-art-c1e2aa9a6e6a4532b568b23d242db4572025-01-22T05:41:21ZengElsevierDevelopmental Cognitive Neuroscience1878-92932025-01-0171101509Fear extinction retention in children, adolescents, and adultsEbba Widegren0Johan Vegelius1Matilda A. Frick2Ashika A. Roy3Stefan Möller4Johan Lundin Kleberg5Johanna Motilla Hoppe6Olof Hjorth7David Fällmar8Daniel S. Pine9Karin Brocki10Malin Gingnell11Andreas Frick12Department of Medical Sciences, Experimental Cognitive and Affective Neuroscience Lab, Uppsala University, Uppsala, SwedenDepartment of Medical Sciences, Experimental Cognitive and Affective Neuroscience Lab, Uppsala University, Uppsala, SwedenDepartment of Medical Sciences, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden; Department of Psychology, Stockholm University, Stockholm, SwedenDepartment of Medical Sciences, Experimental Cognitive and Affective Neuroscience Lab, Uppsala University, Uppsala, SwedenDepartment of Psychology, Lund University, Lund, SwedenDepartment of Psychology, Stockholm University, Stockholm, SwedenDepartment of Medical Sciences, Experimental Cognitive and Affective Neuroscience Lab, Uppsala University, Uppsala, Sweden; Department of Psychology, Uppsala University, Uppsala, SwedenDepartment of Psychology, Uppsala University, Uppsala, SwedenDepartment of Surgical Sciences, Neuroradiology, Uppsala University Hospital, Uppsala, SwedenSection on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USADepartment of Psychology, Uppsala University, Uppsala, SwedenDepartment of Medical Sciences, Experimental Cognitive and Affective Neuroscience Lab, Uppsala University, Uppsala, SwedenDepartment of Medical Sciences, Experimental Cognitive and Affective Neuroscience Lab, Uppsala University, Uppsala, Sweden; Correspondence to: Department of Medical Sciences, Uppsala University, Uppsala University Hospital, Entrance 10, Uppsala 751 85, Sweden.Past results suggest that fear extinction and the return of extinguished fear are compromised in adolescents. However, findings have been inconclusive as there is a lack of fear extinction and extinction retention studies including children, adolescents and adults. In the present study, 36 children (6–9 years), 40 adolescents (13–17 years) and 44 adults (30–40 years), underwent a two-day fear conditioning task. Habituation, acquisition, and extinction were performed on the first day and an extinction retention test > 24 h later. Skin conductance responses were recorded during all phases of fear conditioning and functional magnetic resonance imaging (fMRI) was conducted during the fear retention test. All groups acquired and extinguished fear as measured with SCR, with no group differences in SCR during extinction retention. The groups had largely similar neural fear responses during the retention test, apart from adolescents displaying stronger amygdala fear response than children, with no differences between adolescents and adults. The findings do not support an adolescent extinction dip, and there was only marginal evidence of progressive changes in fear conditioning across development. In contrast to findings in rodents, fear conditioning in humans may elicit similar physiological responses and recruit similar neural networks from childhood to adulthood.http://www.sciencedirect.com/science/article/pii/S1878929325000040Fear conditioningThreat conditioningDevelopmentFear extinctionFear retentionFMRI |
| spellingShingle | Ebba Widegren Johan Vegelius Matilda A. Frick Ashika A. Roy Stefan Möller Johan Lundin Kleberg Johanna Motilla Hoppe Olof Hjorth David Fällmar Daniel S. Pine Karin Brocki Malin Gingnell Andreas Frick Fear extinction retention in children, adolescents, and adults Developmental Cognitive Neuroscience Fear conditioning Threat conditioning Development Fear extinction Fear retention FMRI |
| title | Fear extinction retention in children, adolescents, and adults |
| title_full | Fear extinction retention in children, adolescents, and adults |
| title_fullStr | Fear extinction retention in children, adolescents, and adults |
| title_full_unstemmed | Fear extinction retention in children, adolescents, and adults |
| title_short | Fear extinction retention in children, adolescents, and adults |
| title_sort | fear extinction retention in children adolescents and adults |
| topic | Fear conditioning Threat conditioning Development Fear extinction Fear retention FMRI |
| url | http://www.sciencedirect.com/science/article/pii/S1878929325000040 |
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