Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patients
Background and purpose: A recent study investigated the use of PSMA-PET in monitoring loss of secretory cells in salivary glands of head and neck cancer (HNC) patients. Previously, a dose–effect relation has been formulated to the PSMA-PET uptake in salivary glands. The aim of this study was to deri...
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| Language: | English |
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Elsevier
2025-05-01
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| Series: | Clinical and Translational Radiation Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630824001873 |
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| author | Dirk Wagenaar Vineet Mohan Johannes A. Langendijk Roel J.H.M. Steenbakkers Wouter V. Vogel Stefan Both |
| author_facet | Dirk Wagenaar Vineet Mohan Johannes A. Langendijk Roel J.H.M. Steenbakkers Wouter V. Vogel Stefan Both |
| author_sort | Dirk Wagenaar |
| collection | DOAJ |
| description | Background and purpose: A recent study investigated the use of PSMA-PET in monitoring loss of secretory cells in salivary glands of head and neck cancer (HNC) patients. Previously, a dose–effect relation has been formulated to the PSMA-PET uptake in salivary glands. The aim of this study was to derive a proton RBE model from the PSMA-PET uptake in salivary glands after proton therapy of HNC patients. Materials and methods: Six patients treated with proton therapy were included. These patients received a PET-CT scan using 68Ga (N = 1) or 18F (N = 5) PSMA before treatment (baseline) and one month after the last fraction (follow-up). Physical dose (D), D·LETd and the follow-up PSMA-PET scan were deformed to the baseline PET-CT using deformable image registration. Parotid and submandibular gland delineations were adjusted to include voxels which had an uptake of ≥ 5 g/ml in the baseline PSMA-PET scan. Results: The average RBE-LET slope was 0.075 [0.009; 0.125] (keV/μm)-1 (mean [95 %CI]) for parotid and submandibular glands combined. When analyzing parotid or submandibular glands separately the RBE-LET curve slope varies with two and five patients showing a positive RBE-LET slope when only analyzing parotid or submandibular glands respectively. Conclusion: Our study did not find clear evidence of an increased RBE in parotid and submandibular glands with increasing LETd. On average an LETd effect was observed, however our sample size was too small to clearly define an RBE-LET relation. A larger cohort scanned at later time intervals could shed more light on this issue. |
| format | Article |
| id | doaj-art-c1de544a4de24c238f35d4bcada87e39 |
| institution | Kabale University |
| issn | 2405-6308 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj-art-c1de544a4de24c238f35d4bcada87e392025-01-26T05:04:12ZengElsevierClinical and Translational Radiation Oncology2405-63082025-05-0152100910Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patientsDirk Wagenaar0Vineet Mohan1Johannes A. Langendijk2Roel J.H.M. Steenbakkers3Wouter V. Vogel4Stefan Both5Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Corresponding author at: P.O.Box 30.0001, 9700 RB Groningen, the Netherlands.Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, the NetherlandsDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, the NetherlandsDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsBackground and purpose: A recent study investigated the use of PSMA-PET in monitoring loss of secretory cells in salivary glands of head and neck cancer (HNC) patients. Previously, a dose–effect relation has been formulated to the PSMA-PET uptake in salivary glands. The aim of this study was to derive a proton RBE model from the PSMA-PET uptake in salivary glands after proton therapy of HNC patients. Materials and methods: Six patients treated with proton therapy were included. These patients received a PET-CT scan using 68Ga (N = 1) or 18F (N = 5) PSMA before treatment (baseline) and one month after the last fraction (follow-up). Physical dose (D), D·LETd and the follow-up PSMA-PET scan were deformed to the baseline PET-CT using deformable image registration. Parotid and submandibular gland delineations were adjusted to include voxels which had an uptake of ≥ 5 g/ml in the baseline PSMA-PET scan. Results: The average RBE-LET slope was 0.075 [0.009; 0.125] (keV/μm)-1 (mean [95 %CI]) for parotid and submandibular glands combined. When analyzing parotid or submandibular glands separately the RBE-LET curve slope varies with two and five patients showing a positive RBE-LET slope when only analyzing parotid or submandibular glands respectively. Conclusion: Our study did not find clear evidence of an increased RBE in parotid and submandibular glands with increasing LETd. On average an LETd effect was observed, however our sample size was too small to clearly define an RBE-LET relation. A larger cohort scanned at later time intervals could shed more light on this issue.http://www.sciencedirect.com/science/article/pii/S2405630824001873 |
| spellingShingle | Dirk Wagenaar Vineet Mohan Johannes A. Langendijk Roel J.H.M. Steenbakkers Wouter V. Vogel Stefan Both Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patients Clinical and Translational Radiation Oncology |
| title | Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patients |
| title_full | Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patients |
| title_fullStr | Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patients |
| title_full_unstemmed | Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patients |
| title_short | Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patients |
| title_sort | relating proton letd to biological response of parotid and submandibular glands using psma pet in clinical patients |
| url | http://www.sciencedirect.com/science/article/pii/S2405630824001873 |
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