Cytokine Patterns in Brain Tumour Progression
Inflammation represents the immune system response to external or internal aggressors such as injury or infection in certain tissues. The body’s response to cancer has many parallels with inflammation and repair; the inflammatory cells and cytokines present in tumours are more likely to contribute t...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/979748 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567260233859072 |
|---|---|
| author | Radu Albulescu Elena Codrici Ionela Daniela Popescu Simona Mihai Laura Georgiana Necula Daniel Petrescu Mihaela Teodoru Cristiana Pistol Tanase |
| author_facet | Radu Albulescu Elena Codrici Ionela Daniela Popescu Simona Mihai Laura Georgiana Necula Daniel Petrescu Mihaela Teodoru Cristiana Pistol Tanase |
| author_sort | Radu Albulescu |
| collection | DOAJ |
| description | Inflammation represents the immune system response to external or internal aggressors such as injury or infection in certain tissues. The body’s response to cancer has many parallels with inflammation and repair; the inflammatory cells and cytokines present in tumours are more likely to contribute to tumour growth, progression, and immunosuppression, rather than in building an effective antitumour defence. Using new proteomic technology, we have investigated serum profile of pro- (IL-1β, IL-6, IL-8, IL-12, GM-CSF, and TNF-α) and anti-inflammatory cytokines (IL-4, IL-10), along with angiogenic factors (VEGF, bFGF) in order to assess tumoural aggressiveness. Our results indicate significant dysregulation in serum levels of cytokines and angiogenic factors, with over threefold upregulation of IL-6, IL-1β, TNF-α, and IL-10 and up to twofold upregulation of VEGF, FGF-2, IL-8, IL-2, and GM-CSF. These molecules are involved in tumour progression and aggressiveness, and are also involved in a generation of disease associated pain. |
| format | Article |
| id | doaj-art-c1c978ac5c6e4fec887a673614de6c40 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c1c978ac5c6e4fec887a673614de6c402025-02-03T01:01:56ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/979748979748Cytokine Patterns in Brain Tumour ProgressionRadu Albulescu0Elena Codrici1Ionela Daniela Popescu2Simona Mihai3Laura Georgiana Necula4Daniel Petrescu5Mihaela Teodoru6Cristiana Pistol Tanase7Victor Babes National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaVictor Babes National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaVictor Babes National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaVictor Babes National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaVictor Babes National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaNeurology and Neurovascular Diseases National Institute, 10-12 Soseaua Berceni, 041914 Bucharest, RomaniaElias Emergency University Hospital, 19 Bulevardul Marasti, 011462 Bucharest, RomaniaVictor Babes National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaInflammation represents the immune system response to external or internal aggressors such as injury or infection in certain tissues. The body’s response to cancer has many parallels with inflammation and repair; the inflammatory cells and cytokines present in tumours are more likely to contribute to tumour growth, progression, and immunosuppression, rather than in building an effective antitumour defence. Using new proteomic technology, we have investigated serum profile of pro- (IL-1β, IL-6, IL-8, IL-12, GM-CSF, and TNF-α) and anti-inflammatory cytokines (IL-4, IL-10), along with angiogenic factors (VEGF, bFGF) in order to assess tumoural aggressiveness. Our results indicate significant dysregulation in serum levels of cytokines and angiogenic factors, with over threefold upregulation of IL-6, IL-1β, TNF-α, and IL-10 and up to twofold upregulation of VEGF, FGF-2, IL-8, IL-2, and GM-CSF. These molecules are involved in tumour progression and aggressiveness, and are also involved in a generation of disease associated pain.http://dx.doi.org/10.1155/2013/979748 |
| spellingShingle | Radu Albulescu Elena Codrici Ionela Daniela Popescu Simona Mihai Laura Georgiana Necula Daniel Petrescu Mihaela Teodoru Cristiana Pistol Tanase Cytokine Patterns in Brain Tumour Progression Mediators of Inflammation |
| title | Cytokine Patterns in Brain Tumour Progression |
| title_full | Cytokine Patterns in Brain Tumour Progression |
| title_fullStr | Cytokine Patterns in Brain Tumour Progression |
| title_full_unstemmed | Cytokine Patterns in Brain Tumour Progression |
| title_short | Cytokine Patterns in Brain Tumour Progression |
| title_sort | cytokine patterns in brain tumour progression |
| url | http://dx.doi.org/10.1155/2013/979748 |
| work_keys_str_mv | AT radualbulescu cytokinepatternsinbraintumourprogression AT elenacodrici cytokinepatternsinbraintumourprogression AT ioneladanielapopescu cytokinepatternsinbraintumourprogression AT simonamihai cytokinepatternsinbraintumourprogression AT laurageorgiananecula cytokinepatternsinbraintumourprogression AT danielpetrescu cytokinepatternsinbraintumourprogression AT mihaelateodoru cytokinepatternsinbraintumourprogression AT cristianapistoltanase cytokinepatternsinbraintumourprogression |