Molecularly-imprinted silica nanoparticles for rapid and selective detection of atenolol in artificial urine samples
Herein, a novel molecularly imprinted polymer was synthesized on silica nanoparticles via surface imprinting approach for rapid, sensitive and selective detection of atenolol in artificial urine samples. For this purpose, silica nanoparticles were firstly modified with methacryloxy group for surface...
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| Language: | English |
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Kyrgyz Turkish Manas University
2021-04-01
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| Series: | MANAS: Journal of Engineering |
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| Online Access: | https://dergipark.org.tr/en/download/article-file/1504149 |
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| author | Adem Zengin |
| author_facet | Adem Zengin |
| author_sort | Adem Zengin |
| collection | DOAJ |
| description | Herein, a novel molecularly imprinted polymer was synthesized on silica nanoparticles via surface imprinting approach for rapid, sensitive and selective detection of atenolol in artificial urine samples. For this purpose, silica nanoparticles were firstly modified with methacryloxy group for surface initiated polymerization and then, polymerization was carried out in the presence of 2-hydroxyethyl methacrylate (functional monomer), ethylene glycol dimethacrylate (cross-linker), azobisisobutyronitrile (initiator), atenolol (template) and acetonitrile (porogen). The surface characterization of imprinted nanoparticles indicated that a thin polymer layer was grafted on the silica nanoparticles. The rebinding properties of the imprinted nanoparticles were investigated in detail and the results revealed that the imprinted nanoparticles had high adsorption capacity (32.06 mg/g), fast adsorption kinetics (15 min for equilibration), high imprinting factor (4.14) towards atenolol and good regeneration ability. The imprinted nanoparticles were also used as selective sorbent for selective extraction and determination of atenolol in artificial urine samples. The results showed that the proposed method good recovery percentages (98.6 %-100.1%) with low standard deviations (less than 4.4%). It is believed that the atenolol-imprinted silica nanoparticles can be used as an alternative sorbent for selective quantification of atenolol in artificial urine samples. |
| format | Article |
| id | doaj-art-c1bd1e2e032841da9702cd8a405fe2d1 |
| institution | Kabale University |
| issn | 1694-7398 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Kyrgyz Turkish Manas University |
| record_format | Article |
| series | MANAS: Journal of Engineering |
| spelling | doaj-art-c1bd1e2e032841da9702cd8a405fe2d12025-02-03T12:07:27ZengKyrgyz Turkish Manas UniversityMANAS: Journal of Engineering1694-73982021-04-019Special 1434810.51354/mjen.8590161437Molecularly-imprinted silica nanoparticles for rapid and selective detection of atenolol in artificial urine samplesAdem Zengin0https://orcid.org/0000-0002-6889-5387Van Yüzüncü Yıl UniversityHerein, a novel molecularly imprinted polymer was synthesized on silica nanoparticles via surface imprinting approach for rapid, sensitive and selective detection of atenolol in artificial urine samples. For this purpose, silica nanoparticles were firstly modified with methacryloxy group for surface initiated polymerization and then, polymerization was carried out in the presence of 2-hydroxyethyl methacrylate (functional monomer), ethylene glycol dimethacrylate (cross-linker), azobisisobutyronitrile (initiator), atenolol (template) and acetonitrile (porogen). The surface characterization of imprinted nanoparticles indicated that a thin polymer layer was grafted on the silica nanoparticles. The rebinding properties of the imprinted nanoparticles were investigated in detail and the results revealed that the imprinted nanoparticles had high adsorption capacity (32.06 mg/g), fast adsorption kinetics (15 min for equilibration), high imprinting factor (4.14) towards atenolol and good regeneration ability. The imprinted nanoparticles were also used as selective sorbent for selective extraction and determination of atenolol in artificial urine samples. The results showed that the proposed method good recovery percentages (98.6 %-100.1%) with low standard deviations (less than 4.4%). It is believed that the atenolol-imprinted silica nanoparticles can be used as an alternative sorbent for selective quantification of atenolol in artificial urine samples.https://dergipark.org.tr/en/download/article-file/1504149molecularly-imprinted polymerssurface imprintingsilica nanoparticlesatenololartificial urine |
| spellingShingle | Adem Zengin Molecularly-imprinted silica nanoparticles for rapid and selective detection of atenolol in artificial urine samples MANAS: Journal of Engineering molecularly-imprinted polymers surface imprinting silica nanoparticles atenolol artificial urine |
| title | Molecularly-imprinted silica nanoparticles for rapid and selective detection of atenolol in artificial urine samples |
| title_full | Molecularly-imprinted silica nanoparticles for rapid and selective detection of atenolol in artificial urine samples |
| title_fullStr | Molecularly-imprinted silica nanoparticles for rapid and selective detection of atenolol in artificial urine samples |
| title_full_unstemmed | Molecularly-imprinted silica nanoparticles for rapid and selective detection of atenolol in artificial urine samples |
| title_short | Molecularly-imprinted silica nanoparticles for rapid and selective detection of atenolol in artificial urine samples |
| title_sort | molecularly imprinted silica nanoparticles for rapid and selective detection of atenolol in artificial urine samples |
| topic | molecularly-imprinted polymers surface imprinting silica nanoparticles atenolol artificial urine |
| url | https://dergipark.org.tr/en/download/article-file/1504149 |
| work_keys_str_mv | AT ademzengin molecularlyimprintedsilicananoparticlesforrapidandselectivedetectionofatenololinartificialurinesamples |