Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research)
Aim. To evaluate the differences in insulin resistance (IR) among subjects with normal glucose tolerance (NGT), hyperinsulinemia with NGT (HINS), impaired glucose tolerance (IGT), and newly diagnosed type 2 diabetes mellitus (T2DM). Methods. 5 NGT, 25 HINS, 25 IGT, and 25 T2DM subjects participated...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/9270768 |
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| author | Guang Yang Chunlin Li Yanping Gong Fusheng Fang Hui Tian Jian Li Xiaoling Cheng |
| author_facet | Guang Yang Chunlin Li Yanping Gong Fusheng Fang Hui Tian Jian Li Xiaoling Cheng |
| author_sort | Guang Yang |
| collection | DOAJ |
| description | Aim. To evaluate the differences in insulin resistance (IR) among subjects with normal glucose tolerance (NGT), hyperinsulinemia with NGT (HINS), impaired glucose tolerance (IGT), and newly diagnosed type 2 diabetes mellitus (T2DM). Methods. 5 NGT, 25 HINS, 25 IGT, and 25 T2DM subjects participated in this research. The hyperinsulinemic-euglycemic clamp technique (HECT) was performed in all of them to evaluate IR levels. The relative factors influencing IR were evaluated. The simple insulin sensitivity indices were calculated, and the correlation between each index and the M value was analyzed. Results. The M values of NGT, HINS, IGT, and T2DM groups were 11.88 ± 2.93 mg·kg−1·min−1, 6.23 ± 1.73 mg·kg−1·min−1, 6.37 ± 2.12 mg·kg−1·min−1, and 6.19 ± 1.89 mg·kg−1·min−1, respectively. M values in HINS, IGT, and T2DM groups were lower than those in the NGT group (P=0.005); however, the differences among the HINS, IGT, and T2DM groups were not statistically significant (P=0.835). The independent factors influencing the M value were waistline and fasting insulin level (FINS). The simple insulin sensitivity indices, especially Matsuda and Gutt index, were significantly associated with the M value (P<0.01). Conclusion. IR existed in the HINS, IGT, and T2DM groups, and IR levels were consistent in the three groups. The independent factors influencing IR were waistline and FINS. |
| format | Article |
| id | doaj-art-c1958561698940c7a1944741be9f1e95 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-c1958561698940c7a1944741be9f1e952025-02-03T06:44:46ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/92707689270768Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research)Guang Yang0Chunlin Li1Yanping Gong2Fusheng Fang3Hui Tian4Jian Li5Xiaoling Cheng6Department of Geriatric Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaDepartment of Geriatric Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaDepartment of Geriatric Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaDepartment of Geriatric Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaDepartment of Geriatric Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaDepartment of Geriatric Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaDepartment of Geriatric Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaAim. To evaluate the differences in insulin resistance (IR) among subjects with normal glucose tolerance (NGT), hyperinsulinemia with NGT (HINS), impaired glucose tolerance (IGT), and newly diagnosed type 2 diabetes mellitus (T2DM). Methods. 5 NGT, 25 HINS, 25 IGT, and 25 T2DM subjects participated in this research. The hyperinsulinemic-euglycemic clamp technique (HECT) was performed in all of them to evaluate IR levels. The relative factors influencing IR were evaluated. The simple insulin sensitivity indices were calculated, and the correlation between each index and the M value was analyzed. Results. The M values of NGT, HINS, IGT, and T2DM groups were 11.88 ± 2.93 mg·kg−1·min−1, 6.23 ± 1.73 mg·kg−1·min−1, 6.37 ± 2.12 mg·kg−1·min−1, and 6.19 ± 1.89 mg·kg−1·min−1, respectively. M values in HINS, IGT, and T2DM groups were lower than those in the NGT group (P=0.005); however, the differences among the HINS, IGT, and T2DM groups were not statistically significant (P=0.835). The independent factors influencing the M value were waistline and fasting insulin level (FINS). The simple insulin sensitivity indices, especially Matsuda and Gutt index, were significantly associated with the M value (P<0.01). Conclusion. IR existed in the HINS, IGT, and T2DM groups, and IR levels were consistent in the three groups. The independent factors influencing IR were waistline and FINS.http://dx.doi.org/10.1155/2016/9270768 |
| spellingShingle | Guang Yang Chunlin Li Yanping Gong Fusheng Fang Hui Tian Jian Li Xiaoling Cheng Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research) Journal of Diabetes Research |
| title | Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research) |
| title_full | Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research) |
| title_fullStr | Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research) |
| title_full_unstemmed | Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research) |
| title_short | Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research) |
| title_sort | assessment of insulin resistance in subjects with normal glucose tolerance hyperinsulinemia with normal blood glucose tolerance impaired glucose tolerance and newly diagnosed type 2 diabetes prediabetes insulin resistance research |
| url | http://dx.doi.org/10.1155/2016/9270768 |
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