Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context
In Europe and North America, hepatocellular adenomas (HCA) occur, classically, in middle-aged woman taking oral contraceptives. Twenty percent of women, however, are not exposed to oral contraceptives; HCA can more rarely occur in men, children, and women over 65 years. HCA have been observed in man...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2013/253261 |
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| author | Paulette Bioulac-Sage Christine Sempoux Laurent Possenti Nora Frulio Hervé Laumonier Christophe Laurent Laurence Chiche Jean Frédéric Blanc Jean Saric Hervé Trillaud Brigitte Le Bail Charles Balabaud |
| author_facet | Paulette Bioulac-Sage Christine Sempoux Laurent Possenti Nora Frulio Hervé Laumonier Christophe Laurent Laurence Chiche Jean Frédéric Blanc Jean Saric Hervé Trillaud Brigitte Le Bail Charles Balabaud |
| author_sort | Paulette Bioulac-Sage |
| collection | DOAJ |
| description | In Europe and North America, hepatocellular adenomas (HCA) occur, classically, in middle-aged woman taking oral contraceptives. Twenty percent of women, however, are not exposed to oral contraceptives; HCA can more rarely occur in men, children, and women over 65 years. HCA have been observed in many pathological conditions such as glycogenosis, familial adenomatous polyposis, MODY3, after male hormone administration, and in vascular diseases. Obesity is frequent particularly in inflammatory HCA. The background liver is often normal, but steatosis is a frequent finding particularly in inflammatory HCA. The diagnosis of HCA is more difficult when the background liver is fibrotic, notably in vascular diseases. HCA can be solitary, or multiple or in great number (adenomatosis). When nodules are multiple, they are usually of the same subtype. HNF1α-inactivated HCA occur almost exclusively in woman. The most important point of the classification is the identification of β-catenin mutated HCA, a strong argument to identify patients at risk of malignant transformation. Some HCA already present criteria indicating malignant transformation. When the whole nodule is a hepatocellular carcinoma, it is extremely difficult to prove that it is the consequence of a former HCA. It is occasionally difficult to identify HCA remodeled by necrosis or hemorrhage. |
| format | Article |
| id | doaj-art-c1890d9474e845f5ab56fe69e09720ac |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-c1890d9474e845f5ab56fe69e09720ac2025-02-03T05:48:16ZengWileyInternational Journal of Hepatology2090-34482090-34562013-01-01201310.1155/2013/253261253261Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical ContextPaulette Bioulac-Sage0Christine Sempoux1Laurent Possenti2Nora Frulio3Hervé Laumonier4Christophe Laurent5Laurence Chiche6Jean Frédéric Blanc7Jean Saric8Hervé Trillaud9Brigitte Le Bail10Charles Balabaud11Service d’Anatomie Pathologique, Hôpital Pellegrin, CHU Bordeaux, 33076 Bordeaux, FranceService d’Anatomie Pathologique, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumService d’Hépatologie, Gastroenterologie, Hôpital St André CHU Bordeaux, 33000 Bordeaux, FranceService de Radiologie, Hôpital St André CHU Bordeaux, 33000 Bordeaux, FranceService de Radiologie, Hôpital St André CHU Bordeaux, 33000 Bordeaux, FranceService de Chirurgie Digestive, Hôpital St André CHU Bordeaux, 33000 Bordeaux, FranceService Hépatobiliare et Pancréatique, Hôpital Haut Lévêque CHU Bordeaux, 33604 Pessac, FranceU1053 Université Bordeaux 2, 33076 Bordeaux, FranceService de Chirurgie Digestive, Hôpital St André CHU Bordeaux, 33000 Bordeaux, FranceService de Radiologie, Hôpital St André CHU Bordeaux, 33000 Bordeaux, FranceService d’Anatomie Pathologique, Hôpital Pellegrin, CHU Bordeaux, 33076 Bordeaux, FranceU1053 Université Bordeaux 2, 33076 Bordeaux, FranceIn Europe and North America, hepatocellular adenomas (HCA) occur, classically, in middle-aged woman taking oral contraceptives. Twenty percent of women, however, are not exposed to oral contraceptives; HCA can more rarely occur in men, children, and women over 65 years. HCA have been observed in many pathological conditions such as glycogenosis, familial adenomatous polyposis, MODY3, after male hormone administration, and in vascular diseases. Obesity is frequent particularly in inflammatory HCA. The background liver is often normal, but steatosis is a frequent finding particularly in inflammatory HCA. The diagnosis of HCA is more difficult when the background liver is fibrotic, notably in vascular diseases. HCA can be solitary, or multiple or in great number (adenomatosis). When nodules are multiple, they are usually of the same subtype. HNF1α-inactivated HCA occur almost exclusively in woman. The most important point of the classification is the identification of β-catenin mutated HCA, a strong argument to identify patients at risk of malignant transformation. Some HCA already present criteria indicating malignant transformation. When the whole nodule is a hepatocellular carcinoma, it is extremely difficult to prove that it is the consequence of a former HCA. It is occasionally difficult to identify HCA remodeled by necrosis or hemorrhage.http://dx.doi.org/10.1155/2013/253261 |
| spellingShingle | Paulette Bioulac-Sage Christine Sempoux Laurent Possenti Nora Frulio Hervé Laumonier Christophe Laurent Laurence Chiche Jean Frédéric Blanc Jean Saric Hervé Trillaud Brigitte Le Bail Charles Balabaud Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context International Journal of Hepatology |
| title | Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context |
| title_full | Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context |
| title_fullStr | Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context |
| title_full_unstemmed | Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context |
| title_short | Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context |
| title_sort | pathological diagnosis of hepatocellular cellular adenoma according to the clinical context |
| url | http://dx.doi.org/10.1155/2013/253261 |
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