Effect of Hemoadsorption for Cytokine Removal in Pneumococcal and Meningococcal Sepsis
Bacterial meningitis and septicemia are invasive bacterial diseases, representing a significant cause of morbidity and mortality worldwide. Both conditions are characterized by an impressive inflammatory response, resulting rapidly in cerebral edema, infarction, hydrocephalus, and septic shock with...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2018/1205613 |
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| author | Francesca Leonardis Viviana De Angelis Francesca Frisardi Chiara Pietrafitta Ivano Riva Tino Martino Valetti Valentina Broletti Gianmariano Marchesi Lorenza Menato Roberto Nani Franco Marson Mirca Fabbris Luca Cabrini Sergio Colombo Alberto Zangrillo Carlo Coniglio Giovanni Gordini Lucia Stalteri Giovanni Giuliani Vittorio Dalmastri Gaetano La Manna |
| author_facet | Francesca Leonardis Viviana De Angelis Francesca Frisardi Chiara Pietrafitta Ivano Riva Tino Martino Valetti Valentina Broletti Gianmariano Marchesi Lorenza Menato Roberto Nani Franco Marson Mirca Fabbris Luca Cabrini Sergio Colombo Alberto Zangrillo Carlo Coniglio Giovanni Gordini Lucia Stalteri Giovanni Giuliani Vittorio Dalmastri Gaetano La Manna |
| author_sort | Francesca Leonardis |
| collection | DOAJ |
| description | Bacterial meningitis and septicemia are invasive bacterial diseases, representing a significant cause of morbidity and mortality worldwide. Both conditions are characterized by an impressive inflammatory response, resulting rapidly in cerebral edema, infarction, hydrocephalus, and septic shock with multiple organ failure. Despite advances in critical care, outcome and prognosis remain critical. Available adjunctive treatments to control the inflammatory response have shown encouraging results in the evolution of patients with sepsis and systemic inflammation, but meningococcal or pneumococcal infection has not been investigated. We herein report five patients with similar critical pathological conditions, characterized by pneumococcal or meningococcal sepsis and treated with hemoadsorption for cytokine removal. All patients showed a progressive stabilization in hemodynamics along with a rapid and marked reduction of catecholamine dosages, a stabilization in metabolic disorders, and less-than-expected loss of extremities. Therapy proved to be safe and well tolerated. From this first experience, extracorporeal cytokine removal seems to be a valid and safe therapy in the management of meningococcal and pneumococcal diseases and may contribute to the patient stabilization and prevention of severe sequelae. Further studies are required to confirm efficacy in a larger context. |
| format | Article |
| id | doaj-art-c18454fcf2a041bc9e9cf91838287792 |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-c18454fcf2a041bc9e9cf918382877922025-02-03T01:21:08ZengWileyCase Reports in Critical Care2090-64202090-64392018-01-01201810.1155/2018/12056131205613Effect of Hemoadsorption for Cytokine Removal in Pneumococcal and Meningococcal SepsisFrancesca Leonardis0Viviana De Angelis1Francesca Frisardi2Chiara Pietrafitta3Ivano Riva4Tino Martino Valetti5Valentina Broletti6Gianmariano Marchesi7Lorenza Menato8Roberto Nani9Franco Marson10Mirca Fabbris11Luca Cabrini12Sergio Colombo13Alberto Zangrillo14Carlo Coniglio15Giovanni Gordini16Lucia Stalteri17Giovanni Giuliani18Vittorio Dalmastri19Gaetano La Manna20Intensive Care Unit, Fondazione Policlinico Tor Vergata, Viale Oxford 81, 00133 Roma RM, ItalyIntensive Care Unit, Fondazione Policlinico Tor Vergata, Viale Oxford 81, 00133 Roma RM, ItalyIntensive Care Unit, Fondazione Policlinico Tor Vergata, Viale Oxford 81, 00133 Roma RM, ItalyIntensive Care Unit, Fondazione Policlinico Tor Vergata, Viale Oxford 81, 00133 Roma RM, ItalyIntensive Care Unit 3, Department of Anesthesia and Intensive Care, ASST Papa Giovanni XXIII, Piazza OMS 1, 24127 Bergamo BG, ItalyIntensive Care Unit 3, Department of Anesthesia and Intensive Care, ASST Papa Giovanni XXIII, Piazza OMS 1, 24127 Bergamo BG, ItalyIntensive Care Unit 3, Department of Anesthesia and Intensive Care, ASST Papa Giovanni XXIII, Piazza OMS 1, 24127 Bergamo BG, ItalyIntensive Care Unit 3, Department of Anesthesia and Intensive Care, ASST Papa Giovanni XXIII, Piazza OMS 1, 24127 Bergamo BG, ItalyIntensive Care Unit, Azienda ULSS 2 Marca Trevigiana, Presidio Ospedaliero di Treviso, Piazzale dell’Ospedale 1, 31100 Treviso TV, ItalyIntensive Care Unit, Azienda ULSS 2 Marca Trevigiana, Presidio Ospedaliero di Treviso, Piazzale dell’Ospedale 1, 31100 Treviso TV, ItalyIntensive Care Unit, Azienda ULSS 2 Marca Trevigiana, Presidio Ospedaliero di Treviso, Piazzale dell’Ospedale 1, 31100 Treviso TV, ItalyIntensive Care Unit, Azienda ULSS 2 Marca Trevigiana, Presidio Ospedaliero di Treviso, Piazzale dell’Ospedale 1, 31100 Treviso TV, ItalyAnesthesia and Intensive Care Unit, IRCSS San Raffaele, Via Olgettina 60, 20132 Milano MI, ItalyAnesthesia and Intensive Care Unit, IRCSS San Raffaele, Via Olgettina 60, 20132 Milano MI, ItalyAnesthesia and Intensive Care Unit, IRCSS San Raffaele, Via Olgettina 60, 20132 Milano MI, ItalyResuscitation and Territorial Emergency Unit, Maggiore Hospital, Largo Nigrisoli 2, 40133 Bologna BO, ItalyResuscitation and Territorial Emergency Unit, Maggiore Hospital, Largo Nigrisoli 2, 40133 Bologna BO, ItalyNephrology, Dialysis and Transplantation Unit, Azienda Ospedaliera-Universitaria di Bologna, Via Massarenti 9, 40138 Bologna BO, ItalyNephrology, Dialysis and Transplantation Unit, Azienda Ospedaliera-Universitaria di Bologna, Via Massarenti 9, 40138 Bologna BO, ItalyNephrology, Dialysis and Transplantation Unit, Azienda Ospedaliera-Universitaria di Bologna, Via Massarenti 9, 40138 Bologna BO, ItalyNephrology, Dialysis and Transplantation Unit, Azienda Ospedaliera-Universitaria di Bologna, Via Massarenti 9, 40138 Bologna BO, ItalyBacterial meningitis and septicemia are invasive bacterial diseases, representing a significant cause of morbidity and mortality worldwide. Both conditions are characterized by an impressive inflammatory response, resulting rapidly in cerebral edema, infarction, hydrocephalus, and septic shock with multiple organ failure. Despite advances in critical care, outcome and prognosis remain critical. Available adjunctive treatments to control the inflammatory response have shown encouraging results in the evolution of patients with sepsis and systemic inflammation, but meningococcal or pneumococcal infection has not been investigated. We herein report five patients with similar critical pathological conditions, characterized by pneumococcal or meningococcal sepsis and treated with hemoadsorption for cytokine removal. All patients showed a progressive stabilization in hemodynamics along with a rapid and marked reduction of catecholamine dosages, a stabilization in metabolic disorders, and less-than-expected loss of extremities. Therapy proved to be safe and well tolerated. From this first experience, extracorporeal cytokine removal seems to be a valid and safe therapy in the management of meningococcal and pneumococcal diseases and may contribute to the patient stabilization and prevention of severe sequelae. Further studies are required to confirm efficacy in a larger context.http://dx.doi.org/10.1155/2018/1205613 |
| spellingShingle | Francesca Leonardis Viviana De Angelis Francesca Frisardi Chiara Pietrafitta Ivano Riva Tino Martino Valetti Valentina Broletti Gianmariano Marchesi Lorenza Menato Roberto Nani Franco Marson Mirca Fabbris Luca Cabrini Sergio Colombo Alberto Zangrillo Carlo Coniglio Giovanni Gordini Lucia Stalteri Giovanni Giuliani Vittorio Dalmastri Gaetano La Manna Effect of Hemoadsorption for Cytokine Removal in Pneumococcal and Meningococcal Sepsis Case Reports in Critical Care |
| title | Effect of Hemoadsorption for Cytokine Removal in Pneumococcal and Meningococcal Sepsis |
| title_full | Effect of Hemoadsorption for Cytokine Removal in Pneumococcal and Meningococcal Sepsis |
| title_fullStr | Effect of Hemoadsorption for Cytokine Removal in Pneumococcal and Meningococcal Sepsis |
| title_full_unstemmed | Effect of Hemoadsorption for Cytokine Removal in Pneumococcal and Meningococcal Sepsis |
| title_short | Effect of Hemoadsorption for Cytokine Removal in Pneumococcal and Meningococcal Sepsis |
| title_sort | effect of hemoadsorption for cytokine removal in pneumococcal and meningococcal sepsis |
| url | http://dx.doi.org/10.1155/2018/1205613 |
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