Suramin blocked hCAP18/LL-37-induced macrophage recruitment and M2 polarization to enhance the therapeutic efficacy of 1,25(OH)2D3 against hepatocellular carcinoma in vitro and in vivo mouse model

Suramin blocked hCAP18/LL-37-induced macrophage recruitment and M2 polarization to enhance the therapeutic efficacy of 1,25(OH)2D3 against hepatocellular carcinoma in vitro and in vivo mouse model

Background1,25(OH)2D3 supplementation alone does not provide sufficient benefit to hepatocellular carcinoma (HCC) patients in clinical trials. Tumor-associated macrophages (TAMs)-mediated immunosuppression is regarded as a major hurdle for the effectiveness of several treatments. Previous studies re...

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Bibliographic Details
Main Authors: Huidan Zhang, Wenjing Xie, Wenliang Duan, Xueli Yuan, Yaxin Yang, Qin Chen, Yiqiang Zhu, Yuqing Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Nutrition
Subjects:
1,25(OH)2D3
hCAP18/LL-37
suramin
hepatocellular carcinoma
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1556533/full
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