Role of senescent CD4+ T cells in breakthrough infection of the new variant strain of SARS-CoV-2 in elderly patients

Role of senescent CD4+ T cells in breakthrough infection of the new variant strain of SARS-CoV-2 in elderly patients

Abstract Background In late 2022, Beijing, China saw a large-scale BF.7 Omicron variant breakthrough infection. However, the impact of COVID-19 vaccines on elderly breakthrough-infected patients’ antibodies and immune cells response was unclear. Methods We recruited 329 inpatients over 65 with BF.7...

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Main Authors: Zhaoyuan Liang, Hua Zhang, Lu Xu, Nan Li, Zhongnan Yin, Yongchang Sun, Ning Shen, Zhengyang Guo, Yuqing Wang, Lixiang Xue, Jie Zhang, Lin Zeng, Jianling Yang, Siyan Zhan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Online Access:https://doi.org/10.1186/s12967-025-06756-0
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