Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I
Leprosy is a disabling chronic infection, with insidious onset that often evades early detection. In order to detect new leprosy cases in a timely manner, we conducted surveillance visits in some difficult-to-reach mountain areas in South West China where the disease is still prevalent. Our data con...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/352689 |
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| author | Pan Qiong-Hua Zheng Zhong-Yi Yang Jun Wen Yan Yuan Lian-Chao Li Huan-Ying Steven G. Reed Malcolm S. Duthie |
| author_facet | Pan Qiong-Hua Zheng Zhong-Yi Yang Jun Wen Yan Yuan Lian-Chao Li Huan-Ying Steven G. Reed Malcolm S. Duthie |
| author_sort | Pan Qiong-Hua |
| collection | DOAJ |
| description | Leprosy is a disabling chronic infection, with insidious onset that often evades early detection. In order to detect new leprosy cases in a timely manner, we conducted surveillance visits in some difficult-to-reach mountain areas in South West China where the disease is still prevalent. Our data confirm that Chinese multibacillary (MB) leprosy patients have strong antibody responses against Mycobacterium leprae antigens ND-O-BSA and LID-1. Contacts of clinically diagnosed patients were then monitored at regular intervals by both physical examinations and the laboratory determination of antibody responses in sera collected during these examinations. Elevations in antibody titers indicated the onset of MB leprosy in one of the contacts, and diagnosis was subsequently confirmed on physical examination. Our data indicate that rising antibody titers can be used as a trigger for physical examination or increased monitoring of particular individuals in order to provide early leprosy diagnosis. |
| format | Article |
| id | doaj-art-c1700325be17423c9d195c31c92d59f9 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-c1700325be17423c9d195c31c92d59f92025-02-03T01:32:54ZengWileyJournal of Tropical Medicine1687-96861687-96942013-01-01201310.1155/2013/352689352689Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-IPan Qiong-Hua0Zheng Zhong-Yi1Yang Jun2Wen Yan3Yuan Lian-Chao4Li Huan-Ying5Steven G. Reed6Malcolm S. Duthie7Leprosy Hospital, Kaiyuan, Honghe Prefecture, Yunnan Province 661600, ChinaInstitute of Dermatology of Honghe Prefecture, Yunnan 661400, ChinaYunnan Provincial CDC, Kunming, Yunnan 650022, ChinaBeijing Tropical Medicine Research Institute, Beijing Friendship Hospital-Affiliate of Capital University of Medical Sciences, 95 Yong An Road, Beijing 100050, ChinaBeijing Tropical Medicine Research Institute, Beijing Friendship Hospital-Affiliate of Capital University of Medical Sciences, 95 Yong An Road, Beijing 100050, ChinaBeijing Tropical Medicine Research Institute, Beijing Friendship Hospital-Affiliate of Capital University of Medical Sciences, 95 Yong An Road, Beijing 100050, ChinaInfectious Disease Research Institute (IDRI), Seattle, WA 98104, USAInfectious Disease Research Institute (IDRI), Seattle, WA 98104, USALeprosy is a disabling chronic infection, with insidious onset that often evades early detection. In order to detect new leprosy cases in a timely manner, we conducted surveillance visits in some difficult-to-reach mountain areas in South West China where the disease is still prevalent. Our data confirm that Chinese multibacillary (MB) leprosy patients have strong antibody responses against Mycobacterium leprae antigens ND-O-BSA and LID-1. Contacts of clinically diagnosed patients were then monitored at regular intervals by both physical examinations and the laboratory determination of antibody responses in sera collected during these examinations. Elevations in antibody titers indicated the onset of MB leprosy in one of the contacts, and diagnosis was subsequently confirmed on physical examination. Our data indicate that rising antibody titers can be used as a trigger for physical examination or increased monitoring of particular individuals in order to provide early leprosy diagnosis.http://dx.doi.org/10.1155/2013/352689 |
| spellingShingle | Pan Qiong-Hua Zheng Zhong-Yi Yang Jun Wen Yan Yuan Lian-Chao Li Huan-Ying Steven G. Reed Malcolm S. Duthie Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I Journal of Tropical Medicine |
| title | Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
| title_full | Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
| title_fullStr | Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
| title_full_unstemmed | Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
| title_short | Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
| title_sort | early revelation of leprosy in china by sequential antibody analyses with lid 1 and pgl i |
| url | http://dx.doi.org/10.1155/2013/352689 |
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