Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum
Dysembryoplastic neuroepithelial tumor (DNT) is a benign neoplasm with typical supratentorial location, but the possibility of these rare tumors can also be located in the posterior fossa must be taken into account. We report a 21-year-old woman that suffered gait instability, headache, and diplopia...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2012/718651 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551423998427136 |
|---|---|
| author | Jesús Vaquero Cristobal Saldaña Santiago Coca Mercedes Zurita |
| author_facet | Jesús Vaquero Cristobal Saldaña Santiago Coca Mercedes Zurita |
| author_sort | Jesús Vaquero |
| collection | DOAJ |
| description | Dysembryoplastic neuroepithelial tumor (DNT) is a benign neoplasm with typical supratentorial location, but the possibility of these rare tumors can also be located in the posterior fossa must be taken into account. We report a 21-year-old woman that suffered gait instability, headache, and diplopia. On CT-scan, an intraparenchymatous cerebellar tumor was disclosed. It was isodense, showing light enhancement after contrast administration. On MRI (T1-weighted image) the tumor was isointense, showing inhomogeneous hyperintensity after-gadolinium administration. On T2-weighted MRI, the tumor was inhomogenously hyperintense. At surgery, a solid and hypervascularized tumor was completely removed. Two years after surgery, the patient is symptom-free. Pathological study showed coexistence of areas of pilocytic astrocytoma with areas in which small rounded oligodendrocyte-like cells (OLC), with strong synaptophysin expression were identified. These neurocytic areas showed an eosinophilic matrix forming microcysts, and cells with aspect of “floating neurons” were occasionally identified. A complex form variant of DNT was diagnosed. Our case suggests that in presence of a cerebellar tumor with features of pilocytic astrocytoma, the possibility of a complex form variant of DNT should be considered. |
| format | Article |
| id | doaj-art-c16de9484c3f422b8c3b07420cff2a40 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-c16de9484c3f422b8c3b07420cff2a402025-02-03T06:01:33ZengWileyCase Reports in Pathology2090-67812090-679X2012-01-01201210.1155/2012/718651718651Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the CerebellumJesús Vaquero0Cristobal Saldaña1Santiago Coca2Mercedes Zurita3Neurosurgical Service, Hospital Puerta de Hierro-Majadahonda, 28222 Madrid, SpainNeurosurgical Service, Hospital Puerta de Hierro-Majadahonda, 28222 Madrid, SpainDepartment of Pathology, Hospital Gómez Ulla, 28047 Madrid, SpainNeuroscience Research Unit, Hospital Puerta de Hierro-Majadahonda, 28222 Madrid, SpainDysembryoplastic neuroepithelial tumor (DNT) is a benign neoplasm with typical supratentorial location, but the possibility of these rare tumors can also be located in the posterior fossa must be taken into account. We report a 21-year-old woman that suffered gait instability, headache, and diplopia. On CT-scan, an intraparenchymatous cerebellar tumor was disclosed. It was isodense, showing light enhancement after contrast administration. On MRI (T1-weighted image) the tumor was isointense, showing inhomogeneous hyperintensity after-gadolinium administration. On T2-weighted MRI, the tumor was inhomogenously hyperintense. At surgery, a solid and hypervascularized tumor was completely removed. Two years after surgery, the patient is symptom-free. Pathological study showed coexistence of areas of pilocytic astrocytoma with areas in which small rounded oligodendrocyte-like cells (OLC), with strong synaptophysin expression were identified. These neurocytic areas showed an eosinophilic matrix forming microcysts, and cells with aspect of “floating neurons” were occasionally identified. A complex form variant of DNT was diagnosed. Our case suggests that in presence of a cerebellar tumor with features of pilocytic astrocytoma, the possibility of a complex form variant of DNT should be considered.http://dx.doi.org/10.1155/2012/718651 |
| spellingShingle | Jesús Vaquero Cristobal Saldaña Santiago Coca Mercedes Zurita Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum Case Reports in Pathology |
| title | Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum |
| title_full | Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum |
| title_fullStr | Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum |
| title_full_unstemmed | Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum |
| title_short | Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum |
| title_sort | complex form variant of dysembryoplastic neuroepithelial tumor of the cerebellum |
| url | http://dx.doi.org/10.1155/2012/718651 |
| work_keys_str_mv | AT jesusvaquero complexformvariantofdysembryoplasticneuroepithelialtumorofthecerebellum AT cristobalsaldana complexformvariantofdysembryoplasticneuroepithelialtumorofthecerebellum AT santiagococa complexformvariantofdysembryoplasticneuroepithelialtumorofthecerebellum AT mercedeszurita complexformvariantofdysembryoplasticneuroepithelialtumorofthecerebellum |