Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma
Objective. The aim of our study was to investigate the expression of EGFR and PTEN in tissues and measure the serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) to evaluate the prognostic factors of patients with epithelioid malignant peritoneal mesothelioma (MPeM). Me...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/7103915 |
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| author | Yufei Liang Guoqi Zheng Wenjie Yin Hui Song Chunying Li Liang Tian Dongliang Yang |
| author_facet | Yufei Liang Guoqi Zheng Wenjie Yin Hui Song Chunying Li Liang Tian Dongliang Yang |
| author_sort | Yufei Liang |
| collection | DOAJ |
| description | Objective. The aim of our study was to investigate the expression of EGFR and PTEN in tissues and measure the serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) to evaluate the prognostic factors of patients with epithelioid malignant peritoneal mesothelioma (MPeM). Methods. 33 patients of pathologically diagnosed epithelioid MPeM tissues were analyzed using immunohistochemistry to detect EGFR and PTEN; the PLR and NLR were determined by using a routine blood test. We analyzed the relationships of these markers to age, sex, asbestos exposure, elevated platelet count, ascites, and clinical stage. Results. EGFR and PTEN expressions were positive in 22 (66.67%) and 7 (21.21%) epithelioid MPeM patients, respectively. However, these two markers as well as PLR and NLR were not significantly associated with age, sex, asbestos exposure, elevated platelet counts, ascites, and clinical stage (P>0.05). The correlation between EGFR and PTEN was negative (r=−0.577, P<0.001), but the correlation between NLR and PLR was positive (r=0.456, P=0.008). The median survival of all patients was 6 months. In univariate analysis, PTEN (P<0.001), PLR (P=0.014), and NLR (P=0.015) affected the overall survival. Multivariate analysis revealed that PTEN and PLR were validated as predictive for overall survival of epithelioid MPeM (HR=0.070, P=0.001, and HR=3.379, P=0.007, respectively). Conclusion. On the basis of these results, it is suggested that PTEN and PLR are risk factors for the prognosis of epithelioid MPeM, which may be targets for selective therapies and improve the outcomes of patients with epithelioid MPeM. |
| format | Article |
| id | doaj-art-c1694161589849eda0db3df960b16dde |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-c1694161589849eda0db3df960b16dde2025-02-03T01:27:12ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/71039157103915Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal MesotheliomaYufei Liang0Guoqi Zheng1Wenjie Yin2Hui Song3Chunying Li4Liang Tian5Dongliang Yang6Department of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaDepartment of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaDepartment of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaDepartment of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaDepartment of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaDepartment of Pathology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaCangzhou Medical College, Cangzhou, Hebei 061001, ChinaObjective. The aim of our study was to investigate the expression of EGFR and PTEN in tissues and measure the serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) to evaluate the prognostic factors of patients with epithelioid malignant peritoneal mesothelioma (MPeM). Methods. 33 patients of pathologically diagnosed epithelioid MPeM tissues were analyzed using immunohistochemistry to detect EGFR and PTEN; the PLR and NLR were determined by using a routine blood test. We analyzed the relationships of these markers to age, sex, asbestos exposure, elevated platelet count, ascites, and clinical stage. Results. EGFR and PTEN expressions were positive in 22 (66.67%) and 7 (21.21%) epithelioid MPeM patients, respectively. However, these two markers as well as PLR and NLR were not significantly associated with age, sex, asbestos exposure, elevated platelet counts, ascites, and clinical stage (P>0.05). The correlation between EGFR and PTEN was negative (r=−0.577, P<0.001), but the correlation between NLR and PLR was positive (r=0.456, P=0.008). The median survival of all patients was 6 months. In univariate analysis, PTEN (P<0.001), PLR (P=0.014), and NLR (P=0.015) affected the overall survival. Multivariate analysis revealed that PTEN and PLR were validated as predictive for overall survival of epithelioid MPeM (HR=0.070, P=0.001, and HR=3.379, P=0.007, respectively). Conclusion. On the basis of these results, it is suggested that PTEN and PLR are risk factors for the prognosis of epithelioid MPeM, which may be targets for selective therapies and improve the outcomes of patients with epithelioid MPeM.http://dx.doi.org/10.1155/2019/7103915 |
| spellingShingle | Yufei Liang Guoqi Zheng Wenjie Yin Hui Song Chunying Li Liang Tian Dongliang Yang Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma Gastroenterology Research and Practice |
| title | Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma |
| title_full | Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma |
| title_fullStr | Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma |
| title_full_unstemmed | Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma |
| title_short | Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma |
| title_sort | significance of egfr and pten expression and plr and nlr for predicting the prognosis of epithelioid malignant peritoneal mesothelioma |
| url | http://dx.doi.org/10.1155/2019/7103915 |
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