Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents
Neutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long thought of as simple killers, but now we recognise them as responsive cells able to adapt to inflammation and orc...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/8968943 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551005012623360 |
|---|---|
| author | Danielle Minns Katie Jane Smith Emily Gwyer Findlay |
| author_facet | Danielle Minns Katie Jane Smith Emily Gwyer Findlay |
| author_sort | Danielle Minns |
| collection | DOAJ |
| description | Neutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long thought of as simple killers, but now we recognise them as responsive cells able to adapt to inflammation and orchestrate subsequent events with some sophistication. Here, we discuss how these rapid responders release mediators which influence later adaptive T cell immunity through influences on DC priming and directly on the T cells themselves. We consider how the release of granule contents by neutrophils—through NETosis or degranulation—is one way in which the innate immune system directs the phenotype of the adaptive immune response. |
| format | Article |
| id | doaj-art-c15763243f844959bc39460b9eb807b7 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c15763243f844959bc39460b9eb807b72025-02-03T06:05:21ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/89689438968943Orchestration of Adaptive T Cell Responses by Neutrophil Granule ContentsDanielle Minns0Katie Jane Smith1Emily Gwyer Findlay2Centre for Inflammation Research, School of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH16 4TJ, UKCentre for Inflammation Research, School of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH16 4TJ, UKCentre for Inflammation Research, School of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH16 4TJ, UKNeutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long thought of as simple killers, but now we recognise them as responsive cells able to adapt to inflammation and orchestrate subsequent events with some sophistication. Here, we discuss how these rapid responders release mediators which influence later adaptive T cell immunity through influences on DC priming and directly on the T cells themselves. We consider how the release of granule contents by neutrophils—through NETosis or degranulation—is one way in which the innate immune system directs the phenotype of the adaptive immune response.http://dx.doi.org/10.1155/2019/8968943 |
| spellingShingle | Danielle Minns Katie Jane Smith Emily Gwyer Findlay Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents Mediators of Inflammation |
| title | Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents |
| title_full | Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents |
| title_fullStr | Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents |
| title_full_unstemmed | Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents |
| title_short | Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents |
| title_sort | orchestration of adaptive t cell responses by neutrophil granule contents |
| url | http://dx.doi.org/10.1155/2019/8968943 |
| work_keys_str_mv | AT danielleminns orchestrationofadaptivetcellresponsesbyneutrophilgranulecontents AT katiejanesmith orchestrationofadaptivetcellresponsesbyneutrophilgranulecontents AT emilygwyerfindlay orchestrationofadaptivetcellresponsesbyneutrophilgranulecontents |