Nanostrategy for Selective Ethyl Carbamate Removal from Fermented Alcoholic Beverages via Molecular Imprinting Technology

Ethyl carbamate (EC), known as urethane, is a naturally occurring potentially carcinogenic metabolite that is widely found in alcoholic beverages and other food-related fermented products. The concern related to the presence of the EC and its toxicity in regularly consumed fermented alcoholic bevera...

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Main Author: Rosa Perestrelo
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Beverages
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Online Access:https://www.mdpi.com/2306-5710/11/2/30
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author Rosa Perestrelo
author_facet Rosa Perestrelo
author_sort Rosa Perestrelo
collection DOAJ
description Ethyl carbamate (EC), known as urethane, is a naturally occurring potentially carcinogenic metabolite that is widely found in alcoholic beverages and other food-related fermented products. The concern related to the presence of the EC and its toxicity in regularly consumed fermented alcoholic beverages raises global interest in assessing the possible risks to human health. EC mitigation approaches, such as molecular imprinting technology (MIT), have been proposed to target EC while preserving the sensory quality of fermented alcoholic beverages. This review explores the principles of MIT, the advantages and disadvantages of the most common polymerisation approach for molecularly imprinted polymer (MIP) synthesis, the analytical techniques used for MIP characterisation, and the strategies used to mitigate EC in fermented alcoholic beverages, with studies reporting removal efficiencies of up to 84%. Additionally, it highlights the novelty and potential of MIPs, offering practical insights into their integration within the production of fermented alcoholic beverages, highlighting their scalability and cost-effectiveness compared to traditional EC mitigation strategies.
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spelling doaj-art-c156c4fe3620448ea05abcb7bfd62a302025-08-20T02:17:20ZengMDPI AGBeverages2306-57102025-02-011123010.3390/beverages11020030Nanostrategy for Selective Ethyl Carbamate Removal from Fermented Alcoholic Beverages via Molecular Imprinting TechnologyRosa Perestrelo0CQM—Centro de Química da Madeira, Campus da Penteada, Universidade da Madeira, 9020-105 Funchal, PortugalEthyl carbamate (EC), known as urethane, is a naturally occurring potentially carcinogenic metabolite that is widely found in alcoholic beverages and other food-related fermented products. The concern related to the presence of the EC and its toxicity in regularly consumed fermented alcoholic beverages raises global interest in assessing the possible risks to human health. EC mitigation approaches, such as molecular imprinting technology (MIT), have been proposed to target EC while preserving the sensory quality of fermented alcoholic beverages. This review explores the principles of MIT, the advantages and disadvantages of the most common polymerisation approach for molecularly imprinted polymer (MIP) synthesis, the analytical techniques used for MIP characterisation, and the strategies used to mitigate EC in fermented alcoholic beverages, with studies reporting removal efficiencies of up to 84%. Additionally, it highlights the novelty and potential of MIPs, offering practical insights into their integration within the production of fermented alcoholic beverages, highlighting their scalability and cost-effectiveness compared to traditional EC mitigation strategies.https://www.mdpi.com/2306-5710/11/2/30ethyl carbamatefermented alcoholic beveragesmolecularly imprinted polymerssynthesischaracterisationapplications
spellingShingle Rosa Perestrelo
Nanostrategy for Selective Ethyl Carbamate Removal from Fermented Alcoholic Beverages via Molecular Imprinting Technology
Beverages
ethyl carbamate
fermented alcoholic beverages
molecularly imprinted polymers
synthesis
characterisation
applications
title Nanostrategy for Selective Ethyl Carbamate Removal from Fermented Alcoholic Beverages via Molecular Imprinting Technology
title_full Nanostrategy for Selective Ethyl Carbamate Removal from Fermented Alcoholic Beverages via Molecular Imprinting Technology
title_fullStr Nanostrategy for Selective Ethyl Carbamate Removal from Fermented Alcoholic Beverages via Molecular Imprinting Technology
title_full_unstemmed Nanostrategy for Selective Ethyl Carbamate Removal from Fermented Alcoholic Beverages via Molecular Imprinting Technology
title_short Nanostrategy for Selective Ethyl Carbamate Removal from Fermented Alcoholic Beverages via Molecular Imprinting Technology
title_sort nanostrategy for selective ethyl carbamate removal from fermented alcoholic beverages via molecular imprinting technology
topic ethyl carbamate
fermented alcoholic beverages
molecularly imprinted polymers
synthesis
characterisation
applications
url https://www.mdpi.com/2306-5710/11/2/30
work_keys_str_mv AT rosaperestrelo nanostrategyforselectiveethylcarbamateremovalfromfermentedalcoholicbeveragesviamolecularimprintingtechnology