Identification of Novel Mutations in Spatacsin and Apolipoprotein B Genes in a Patient with Spastic Paraplegia and Hypobetalipoproteinemia
Complicated hereditary spastic paraplegia (HSP) presents with complex neurological and nonneurological manifestations. We report a patient with autosomal recessive (AR) HSP in whom laboratory investigations revealed hypobetalipoproteinemia raising the possibility of a shared pathophysiology of these...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Case Reports in Genetics |
| Online Access: | http://dx.doi.org/10.1155/2015/219691 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564429713047552 |
|---|---|
| author | Leema Reddy Peddareddygari Raji P. Grewal |
| author_facet | Leema Reddy Peddareddygari Raji P. Grewal |
| author_sort | Leema Reddy Peddareddygari |
| collection | DOAJ |
| description | Complicated hereditary spastic paraplegia (HSP) presents with complex neurological and nonneurological manifestations. We report a patient with autosomal recessive (AR) HSP in whom laboratory investigations revealed hypobetalipoproteinemia raising the possibility of a shared pathophysiology of these clinical features. A lipid profile of his parents disclosed a normal maternal lipid profile. However, the paternal lipid profile was similar to that of the patient suggesting autosomal dominant transmission of this trait. Whole exome sequence analysis was performed and novel mutations were detected in both the SPG11 and the APOB genes. Genetic testing of the parents showed that both APOB variants were inherited from the father while the SPG11 variants were inherited one from each parent. Our results indicate that, in this patient, the hypobetalipoproteinemia and spastic paraplegia are unrelated resulting from mutations in two independent genes. This clinical study provides support for the use of whole exome sequencing as a diagnostic tool for identification of mutations in conditions with complex presentations. |
| format | Article |
| id | doaj-art-c150e211df484bfdbd29df9c3dc9644e |
| institution | Kabale University |
| issn | 2090-6544 2090-6552 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Genetics |
| spelling | doaj-art-c150e211df484bfdbd29df9c3dc9644e2025-02-03T01:11:05ZengWileyCase Reports in Genetics2090-65442090-65522015-01-01201510.1155/2015/219691219691Identification of Novel Mutations in Spatacsin and Apolipoprotein B Genes in a Patient with Spastic Paraplegia and HypobetalipoproteinemiaLeema Reddy Peddareddygari0Raji P. Grewal1The Neuro-Genetics Institute, 501 Elmwood Avenue, Sharon Hill, PA 19079, USANeuroscience Institute, Saint Francis Medical Center, 601 Hamilton Avenue, Trenton, NJ 08629, USAComplicated hereditary spastic paraplegia (HSP) presents with complex neurological and nonneurological manifestations. We report a patient with autosomal recessive (AR) HSP in whom laboratory investigations revealed hypobetalipoproteinemia raising the possibility of a shared pathophysiology of these clinical features. A lipid profile of his parents disclosed a normal maternal lipid profile. However, the paternal lipid profile was similar to that of the patient suggesting autosomal dominant transmission of this trait. Whole exome sequence analysis was performed and novel mutations were detected in both the SPG11 and the APOB genes. Genetic testing of the parents showed that both APOB variants were inherited from the father while the SPG11 variants were inherited one from each parent. Our results indicate that, in this patient, the hypobetalipoproteinemia and spastic paraplegia are unrelated resulting from mutations in two independent genes. This clinical study provides support for the use of whole exome sequencing as a diagnostic tool for identification of mutations in conditions with complex presentations.http://dx.doi.org/10.1155/2015/219691 |
| spellingShingle | Leema Reddy Peddareddygari Raji P. Grewal Identification of Novel Mutations in Spatacsin and Apolipoprotein B Genes in a Patient with Spastic Paraplegia and Hypobetalipoproteinemia Case Reports in Genetics |
| title | Identification of Novel Mutations in Spatacsin and Apolipoprotein B Genes in a Patient with Spastic Paraplegia and Hypobetalipoproteinemia |
| title_full | Identification of Novel Mutations in Spatacsin and Apolipoprotein B Genes in a Patient with Spastic Paraplegia and Hypobetalipoproteinemia |
| title_fullStr | Identification of Novel Mutations in Spatacsin and Apolipoprotein B Genes in a Patient with Spastic Paraplegia and Hypobetalipoproteinemia |
| title_full_unstemmed | Identification of Novel Mutations in Spatacsin and Apolipoprotein B Genes in a Patient with Spastic Paraplegia and Hypobetalipoproteinemia |
| title_short | Identification of Novel Mutations in Spatacsin and Apolipoprotein B Genes in a Patient with Spastic Paraplegia and Hypobetalipoproteinemia |
| title_sort | identification of novel mutations in spatacsin and apolipoprotein b genes in a patient with spastic paraplegia and hypobetalipoproteinemia |
| url | http://dx.doi.org/10.1155/2015/219691 |
| work_keys_str_mv | AT leemareddypeddareddygari identificationofnovelmutationsinspatacsinandapolipoproteinbgenesinapatientwithspasticparaplegiaandhypobetalipoproteinemia AT rajipgrewal identificationofnovelmutationsinspatacsinandapolipoproteinbgenesinapatientwithspasticparaplegiaandhypobetalipoproteinemia |