Fatal acute liver failure following norovirus gastroenteritis in a child: A case report
Norovirus is the leading cause of acute gastroenteritis and rarely present with extra-intestinal manifestations. There are few reported cases of hepatitis following norovirus gastroenteritis, with no documented fatalities. We present a case of fatal acute hepatitis following norovirus gastroenteriti...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034125000243 |
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| author | Rabab Taha Noura Elazhary Sarah Alqhtani Walaa Almansouri |
| author_facet | Rabab Taha Noura Elazhary Sarah Alqhtani Walaa Almansouri |
| author_sort | Rabab Taha |
| collection | DOAJ |
| description | Norovirus is the leading cause of acute gastroenteritis and rarely present with extra-intestinal manifestations. There are few reported cases of hepatitis following norovirus gastroenteritis, with no documented fatalities. We present a case of fatal acute hepatitis following norovirus gastroenteritis in a child. The patient was a previously healthy 6-year-old boy who presented with diarrhea, vomiting, and fever. He was admitted and treated supportively as a case of acute gastroenteritis. Despite treatment, he rapidly developed acute liver failure in the course of gastroenteritis. Other potential causes including drugs and other possible viral infections were ruled out, only norovirus was isolated from his stool. The patient’s liver function continued to deteriorate leading to fulminant liver failure and death within days. |
| format | Article |
| id | doaj-art-c14a10d3a660451f9befe327fd4f8e31 |
| institution | Kabale University |
| issn | 1876-0341 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj-art-c14a10d3a660451f9befe327fd4f8e312025-02-02T05:27:01ZengElsevierJournal of Infection and Public Health1876-03412025-04-01184102675Fatal acute liver failure following norovirus gastroenteritis in a child: A case reportRabab Taha0Noura Elazhary1Sarah Alqhtani2Walaa Almansouri3Department of Internal Medicine, International Medical Center Hospital, Jeddah, Saudi Arabia; Correspondence to: Transplant Infectious Diseases consultant, Department of Internal Medicine, International Medical Center Hospital, Hail Street, Jeddah 23214, Saudi Arabia.Department of Pediatric Infectious Diseases, Al Murjan Hospital, Jeddah, Saudi ArabiaCollege of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi ArabiaKing Abdullah International Medical Research Center, Jeddah, Saudi Arabia; Consultant of Pediatric Infectious Disease, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi ArabiaNorovirus is the leading cause of acute gastroenteritis and rarely present with extra-intestinal manifestations. There are few reported cases of hepatitis following norovirus gastroenteritis, with no documented fatalities. We present a case of fatal acute hepatitis following norovirus gastroenteritis in a child. The patient was a previously healthy 6-year-old boy who presented with diarrhea, vomiting, and fever. He was admitted and treated supportively as a case of acute gastroenteritis. Despite treatment, he rapidly developed acute liver failure in the course of gastroenteritis. Other potential causes including drugs and other possible viral infections were ruled out, only norovirus was isolated from his stool. The patient’s liver function continued to deteriorate leading to fulminant liver failure and death within days.http://www.sciencedirect.com/science/article/pii/S1876034125000243Acute gastroenteritisNorovirusLiver dysfunctionAcute liver failureHepatitisCase report |
| spellingShingle | Rabab Taha Noura Elazhary Sarah Alqhtani Walaa Almansouri Fatal acute liver failure following norovirus gastroenteritis in a child: A case report Journal of Infection and Public Health Acute gastroenteritis Norovirus Liver dysfunction Acute liver failure Hepatitis Case report |
| title | Fatal acute liver failure following norovirus gastroenteritis in a child: A case report |
| title_full | Fatal acute liver failure following norovirus gastroenteritis in a child: A case report |
| title_fullStr | Fatal acute liver failure following norovirus gastroenteritis in a child: A case report |
| title_full_unstemmed | Fatal acute liver failure following norovirus gastroenteritis in a child: A case report |
| title_short | Fatal acute liver failure following norovirus gastroenteritis in a child: A case report |
| title_sort | fatal acute liver failure following norovirus gastroenteritis in a child a case report |
| topic | Acute gastroenteritis Norovirus Liver dysfunction Acute liver failure Hepatitis Case report |
| url | http://www.sciencedirect.com/science/article/pii/S1876034125000243 |
| work_keys_str_mv | AT rababtaha fatalacuteliverfailurefollowingnorovirusgastroenteritisinachildacasereport AT nouraelazhary fatalacuteliverfailurefollowingnorovirusgastroenteritisinachildacasereport AT sarahalqhtani fatalacuteliverfailurefollowingnorovirusgastroenteritisinachildacasereport AT walaaalmansouri fatalacuteliverfailurefollowingnorovirusgastroenteritisinachildacasereport |