Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma
Malignant pleural mesothelioma is rarely associated with nephrotic syndrome. Cryoglobulinemia is found in various pathological statuses, such as hepatitis C virus infection but rarely in malignant neoplasms. We recently encountered a patient with malignant mesothelioma coincident with nephrotic synd...
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Wiley
2022-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2022/8677293 |
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| author | Kei Nagai Hiroaki Tachi Kohei Inoue Atsushi Ueda |
| author_facet | Kei Nagai Hiroaki Tachi Kohei Inoue Atsushi Ueda |
| author_sort | Kei Nagai |
| collection | DOAJ |
| description | Malignant pleural mesothelioma is rarely associated with nephrotic syndrome. Cryoglobulinemia is found in various pathological statuses, such as hepatitis C virus infection but rarely in malignant neoplasms. We recently encountered a patient with malignant mesothelioma coincident with nephrotic syndrome and cryoglobulinemia in the course of chemotherapy. A 60-year-old man employed as a building painter was diagnosed with malignant mesothelioma by lung biopsy two years earlier and was started on chemotherapy. Nivolumab seemed effective in controlling mesothelioma, but skin immune-related adverse events occurred during the course of treatment. After discontinuation of nivolumab and administration of gemcitabine as an alternative therapy, the patient was referred to a nephrologist because of the subsequent development of edema, renal injury, and proteinuria. Following the investigation, he was diagnosed with nephrotic syndrome and cryoglobulinemia with C4-dominant cold activation. However, a percutaneous renal biopsy could not be performed due to persistent severe cough induced by pleural involvement. The patient died a little over three years after the pathological diagnosis of pleural mesothelioma. Our case had three key features nephrotic syndrome was possibly associated with malignant mesothelioma; cryoglobulinemia occurred in malignant mesothelioma; and concomitant nephrotic syndrome and cryoglobulinemia occurred after chemotherapy. Unfortunately, our rare case lacks a basis in renal pathology or evidence of links between the pathogenesis of malignant mesothelioma, cryoglobulinemia, and nephrotic syndrome. This case does not provide a causal mechanism, but may be worth adding to the case list as one of the rare renal involvement in a patient with malignant mesothelioma. |
| format | Article |
| id | doaj-art-c140035c744d47c28ed5d76c3ca9150d |
| institution | Kabale University |
| issn | 2090-665X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-c140035c744d47c28ed5d76c3ca9150d2025-02-03T01:02:53ZengWileyCase Reports in Nephrology2090-665X2022-01-01202210.1155/2022/8677293Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant MesotheliomaKei Nagai0Hiroaki Tachi1Kohei Inoue2Atsushi Ueda3Department of NephrologyDepartment of Respiratory MedicineDepartment of NephrologyDepartment of NephrologyMalignant pleural mesothelioma is rarely associated with nephrotic syndrome. Cryoglobulinemia is found in various pathological statuses, such as hepatitis C virus infection but rarely in malignant neoplasms. We recently encountered a patient with malignant mesothelioma coincident with nephrotic syndrome and cryoglobulinemia in the course of chemotherapy. A 60-year-old man employed as a building painter was diagnosed with malignant mesothelioma by lung biopsy two years earlier and was started on chemotherapy. Nivolumab seemed effective in controlling mesothelioma, but skin immune-related adverse events occurred during the course of treatment. After discontinuation of nivolumab and administration of gemcitabine as an alternative therapy, the patient was referred to a nephrologist because of the subsequent development of edema, renal injury, and proteinuria. Following the investigation, he was diagnosed with nephrotic syndrome and cryoglobulinemia with C4-dominant cold activation. However, a percutaneous renal biopsy could not be performed due to persistent severe cough induced by pleural involvement. The patient died a little over three years after the pathological diagnosis of pleural mesothelioma. Our case had three key features nephrotic syndrome was possibly associated with malignant mesothelioma; cryoglobulinemia occurred in malignant mesothelioma; and concomitant nephrotic syndrome and cryoglobulinemia occurred after chemotherapy. Unfortunately, our rare case lacks a basis in renal pathology or evidence of links between the pathogenesis of malignant mesothelioma, cryoglobulinemia, and nephrotic syndrome. This case does not provide a causal mechanism, but may be worth adding to the case list as one of the rare renal involvement in a patient with malignant mesothelioma.http://dx.doi.org/10.1155/2022/8677293 |
| spellingShingle | Kei Nagai Hiroaki Tachi Kohei Inoue Atsushi Ueda Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma Case Reports in Nephrology |
| title | Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma |
| title_full | Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma |
| title_fullStr | Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma |
| title_full_unstemmed | Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma |
| title_short | Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma |
| title_sort | concomitant nephrotic syndrome and cryoglobulinemia in a case of malignant mesothelioma |
| url | http://dx.doi.org/10.1155/2022/8677293 |
| work_keys_str_mv | AT keinagai concomitantnephroticsyndromeandcryoglobulinemiainacaseofmalignantmesothelioma AT hiroakitachi concomitantnephroticsyndromeandcryoglobulinemiainacaseofmalignantmesothelioma AT koheiinoue concomitantnephroticsyndromeandcryoglobulinemiainacaseofmalignantmesothelioma AT atsushiueda concomitantnephroticsyndromeandcryoglobulinemiainacaseofmalignantmesothelioma |