Evaluation of New Film Based on Chitosan/Gold Nanocomposites on Antibacterial Property and Wound-Healing Efficacy
Chitosan (CS) is a natural polymer with applications in wound restorations and coatings for artificial implants. However, the lack of antimicrobial activity restricts its further application. Thus, the purpose of this study is to prepare CS/AuNPs film by adding gold nanoparticles (AuNPs) to modify c...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2020/6212540 |
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| author | Kai Wang Haosheng Wang Su Pan Chuan Fu YuXin Chang Hongru Li Xiaoyu Yang Zhiping Qi |
| author_facet | Kai Wang Haosheng Wang Su Pan Chuan Fu YuXin Chang Hongru Li Xiaoyu Yang Zhiping Qi |
| author_sort | Kai Wang |
| collection | DOAJ |
| description | Chitosan (CS) is a natural polymer with applications in wound restorations and coatings for artificial implants. However, the lack of antimicrobial activity restricts its further application. Thus, the purpose of this study is to prepare CS/AuNPs film by adding gold nanoparticles (AuNPs) to modify chitosan. Through transmission electron microscopy, we found that the presence of CS can effectively prevent the agglomeration of nanoparticles. Furthermore, through the CCK experiment, we found that AuNPs at a certain concentration can improve the adhesion and proliferation of cells, which has also been proved in animal experiments, including gross appearance, histological observations, and immunofluorescence staining. Such findings support the feasibility of using the film as a promising candidate for tissue engineering of skin in a near future. |
| format | Article |
| id | doaj-art-c139e598f6c54eefb92355b339dbd1b7 |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-c139e598f6c54eefb92355b339dbd1b72025-02-03T06:43:31ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422020-01-01202010.1155/2020/62125406212540Evaluation of New Film Based on Chitosan/Gold Nanocomposites on Antibacterial Property and Wound-Healing EfficacyKai Wang0Haosheng Wang1Su Pan2Chuan Fu3YuXin Chang4Hongru Li5Xiaoyu Yang6Zhiping Qi7The Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaChitosan (CS) is a natural polymer with applications in wound restorations and coatings for artificial implants. However, the lack of antimicrobial activity restricts its further application. Thus, the purpose of this study is to prepare CS/AuNPs film by adding gold nanoparticles (AuNPs) to modify chitosan. Through transmission electron microscopy, we found that the presence of CS can effectively prevent the agglomeration of nanoparticles. Furthermore, through the CCK experiment, we found that AuNPs at a certain concentration can improve the adhesion and proliferation of cells, which has also been proved in animal experiments, including gross appearance, histological observations, and immunofluorescence staining. Such findings support the feasibility of using the film as a promising candidate for tissue engineering of skin in a near future.http://dx.doi.org/10.1155/2020/6212540 |
| spellingShingle | Kai Wang Haosheng Wang Su Pan Chuan Fu YuXin Chang Hongru Li Xiaoyu Yang Zhiping Qi Evaluation of New Film Based on Chitosan/Gold Nanocomposites on Antibacterial Property and Wound-Healing Efficacy Advances in Materials Science and Engineering |
| title | Evaluation of New Film Based on Chitosan/Gold Nanocomposites on Antibacterial Property and Wound-Healing Efficacy |
| title_full | Evaluation of New Film Based on Chitosan/Gold Nanocomposites on Antibacterial Property and Wound-Healing Efficacy |
| title_fullStr | Evaluation of New Film Based on Chitosan/Gold Nanocomposites on Antibacterial Property and Wound-Healing Efficacy |
| title_full_unstemmed | Evaluation of New Film Based on Chitosan/Gold Nanocomposites on Antibacterial Property and Wound-Healing Efficacy |
| title_short | Evaluation of New Film Based on Chitosan/Gold Nanocomposites on Antibacterial Property and Wound-Healing Efficacy |
| title_sort | evaluation of new film based on chitosan gold nanocomposites on antibacterial property and wound healing efficacy |
| url | http://dx.doi.org/10.1155/2020/6212540 |
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