Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats
The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromyc...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/928137 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559859167395840 |
|---|---|
| author | Ayse Er |
| author_facet | Ayse Er |
| author_sort | Ayse Er |
| collection | DOAJ |
| description | The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromycin group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy; lipopolysaccharide group, where LPS was administered intravenously via the tail vein at 160 μg kg−1 on day 10 of pregnancy; and the azithromycin + LPS group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy and LPS was administered intravenously at 160 μg kg−1 on day 10 of pregnancy. Blood samples were obtained from the tail vein on day 10 of the experiment. Pregnancy rates were determined. Tumor necrosis factor-alpha (TNF-α) and interleukin (IL-10) levels were measured by ELISA. Azithromycin prevented () LPS-induced pregnancy loss. Higher TNF-α and IL-10 levels were measured () in the LPS and azithromycin + LPS groups, respectively. In conclusion, azithromycin may be useful in infection- or endotoxemia-dependent pregnancy loss. |
| format | Article |
| id | doaj-art-c1353370fd0047548e69aa981f02b2a9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c1353370fd0047548e69aa981f02b2a92025-02-03T01:29:09ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/928137928137Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in RatsAyse Er0Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, 42075 Konya, TurkeyThe aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromycin group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy; lipopolysaccharide group, where LPS was administered intravenously via the tail vein at 160 μg kg−1 on day 10 of pregnancy; and the azithromycin + LPS group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy and LPS was administered intravenously at 160 μg kg−1 on day 10 of pregnancy. Blood samples were obtained from the tail vein on day 10 of the experiment. Pregnancy rates were determined. Tumor necrosis factor-alpha (TNF-α) and interleukin (IL-10) levels were measured by ELISA. Azithromycin prevented () LPS-induced pregnancy loss. Higher TNF-α and IL-10 levels were measured () in the LPS and azithromycin + LPS groups, respectively. In conclusion, azithromycin may be useful in infection- or endotoxemia-dependent pregnancy loss.http://dx.doi.org/10.1155/2013/928137 |
| spellingShingle | Ayse Er Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats Mediators of Inflammation |
| title | Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats |
| title_full | Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats |
| title_fullStr | Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats |
| title_full_unstemmed | Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats |
| title_short | Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats |
| title_sort | azithromycin prevents pregnancy loss reducing the level of tumor necrosis factor alpha and raising the level of interleukin 10 in rats |
| url | http://dx.doi.org/10.1155/2013/928137 |
| work_keys_str_mv | AT ayseer azithromycinpreventspregnancylossreducingtheleveloftumornecrosisfactoralphaandraisingthelevelofinterleukin10inrats |