TIRAP, TRAM, and Toll-Like Receptors: The Untold Story
Toll-like receptors (TLRs) are the most studied receptors among the pattern recognition receptors (PRRs). They act as microbial sensors, playing major roles in the regulation of the innate immune system. TLRs mediate their cellular functions through the activation of MyD88-dependent or MyD88-indepen...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/2899271 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548011053416448 |
|---|---|
| author | Valérie Lannoy Anthony Côté-Biron Claude Asselin Nathalie Rivard |
| author_facet | Valérie Lannoy Anthony Côté-Biron Claude Asselin Nathalie Rivard |
| author_sort | Valérie Lannoy |
| collection | DOAJ |
| description | Toll-like receptors (TLRs) are the most studied receptors among the pattern recognition receptors (PRRs). They act as microbial sensors, playing major roles in the regulation of the innate immune system. TLRs mediate their cellular functions through the activation of MyD88-dependent or MyD88-independent signaling pathways. Myd88, or myeloid differentiation primary response 88, is a cytosolic adaptor protein essential for the induction of proinflammatory cytokines by all TLRs except TLR3. While the crucial role of Myd88 is well described, the contribution of other adaptors in mediating TLR signaling and function has been underestimated. In this review, we highlight important results demonstrating that TIRAP and TRAM adaptors are also required for full signaling activity and responses induced by most TLRs. |
| format | Article |
| id | doaj-art-c12c609499694b24820d7bb007b4b108 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c12c609499694b24820d7bb007b4b1082025-02-03T06:42:37ZengWileyMediators of Inflammation1466-18612023-01-01202310.1155/2023/2899271TIRAP, TRAM, and Toll-Like Receptors: The Untold StoryValérie Lannoy0Anthony Côté-Biron1Claude Asselin2Nathalie Rivard3Department of Immunology and Cell BiologyDepartment of Immunology and Cell BiologyDepartment of Immunology and Cell BiologyDepartment of Immunology and Cell BiologyToll-like receptors (TLRs) are the most studied receptors among the pattern recognition receptors (PRRs). They act as microbial sensors, playing major roles in the regulation of the innate immune system. TLRs mediate their cellular functions through the activation of MyD88-dependent or MyD88-independent signaling pathways. Myd88, or myeloid differentiation primary response 88, is a cytosolic adaptor protein essential for the induction of proinflammatory cytokines by all TLRs except TLR3. While the crucial role of Myd88 is well described, the contribution of other adaptors in mediating TLR signaling and function has been underestimated. In this review, we highlight important results demonstrating that TIRAP and TRAM adaptors are also required for full signaling activity and responses induced by most TLRs.http://dx.doi.org/10.1155/2023/2899271 |
| spellingShingle | Valérie Lannoy Anthony Côté-Biron Claude Asselin Nathalie Rivard TIRAP, TRAM, and Toll-Like Receptors: The Untold Story Mediators of Inflammation |
| title | TIRAP, TRAM, and Toll-Like Receptors: The Untold Story |
| title_full | TIRAP, TRAM, and Toll-Like Receptors: The Untold Story |
| title_fullStr | TIRAP, TRAM, and Toll-Like Receptors: The Untold Story |
| title_full_unstemmed | TIRAP, TRAM, and Toll-Like Receptors: The Untold Story |
| title_short | TIRAP, TRAM, and Toll-Like Receptors: The Untold Story |
| title_sort | tirap tram and toll like receptors the untold story |
| url | http://dx.doi.org/10.1155/2023/2899271 |
| work_keys_str_mv | AT valerielannoy tiraptramandtolllikereceptorstheuntoldstory AT anthonycotebiron tiraptramandtolllikereceptorstheuntoldstory AT claudeasselin tiraptramandtolllikereceptorstheuntoldstory AT nathalierivard tiraptramandtolllikereceptorstheuntoldstory |