Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus
Previous functional magnetic resonance imaging (fMRI) analyses have shown that the dorsal attention network (DAN) is involved in the pathophysiological changes of tinnitus, but few relevant studies have been conducted, and the conclusions to date are not uniform. The purpose of this research was to...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/2804533 |
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| author | Haimeng Hu Yining Lyu Shihong Li Zheng Yuan Chuntao Ye Zhao Han Guangwu Lin |
| author_facet | Haimeng Hu Yining Lyu Shihong Li Zheng Yuan Chuntao Ye Zhao Han Guangwu Lin |
| author_sort | Haimeng Hu |
| collection | DOAJ |
| description | Previous functional magnetic resonance imaging (fMRI) analyses have shown that the dorsal attention network (DAN) is involved in the pathophysiological changes of tinnitus, but few relevant studies have been conducted, and the conclusions to date are not uniform. The purpose of this research was to test whether there is a change in intrinsic functional connectivity (FC) patterns between the DAN and other brain regions in tinnitus patients. Thirty-one patients with persistent tinnitus and thirty-three healthy controls were enrolled in this study. A group independent component analysis (ICA), degree centrality (DC) analysis, and seed-based FC analysis were conducted. In the group ICA, the tinnitus patients showed increased connectivity in the left superior parietal gyrus in the DAN compared to the healthy controls. Compared with the healthy controls, the tinnitus patients showed increased DC in the left inferior parietal gyrus and decreased DC in the left precuneus within the DAN. The clusters within the DAN with significant differences in the ICA or DC analysis between the tinnitus patients and the healthy controls were selected as regions of interest (ROIs) for seeds. The tinnitus patients exhibited significantly increased FC from the left superior parietal gyrus to several brain regions, including the left inferior parietal gyrus, the left superior marginal gyrus, and the right superior frontal gyrus, and decreased FC to the right anterior cingulate cortex. The tinnitus patients exhibited decreased FC from the left precuneus to the left inferior occipital gyrus, left calcarine cortex, and left superior frontal gyrus compared with the healthy controls. The findings of this study show that compared with healthy controls, tinnitus patients have altered functional connections not only within the DAN but also between the DAN and other brain regions. These results suggest that it may be possible to improve the disturbance and influence of tinnitus by regulating the DAN. |
| format | Article |
| id | doaj-art-c1298c8df38e451db463c47e10aea788 |
| institution | Kabale University |
| issn | 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-c1298c8df38e451db463c47e10aea7882025-02-03T01:04:11ZengWileyNeural Plasticity1687-54432021-01-01202110.1155/2021/2804533Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in TinnitusHaimeng Hu0Yining Lyu1Shihong Li2Zheng Yuan3Chuntao Ye4Zhao Han5Guangwu Lin6Department of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of OtorhinolaryngologyDepartment of RadiologyPrevious functional magnetic resonance imaging (fMRI) analyses have shown that the dorsal attention network (DAN) is involved in the pathophysiological changes of tinnitus, but few relevant studies have been conducted, and the conclusions to date are not uniform. The purpose of this research was to test whether there is a change in intrinsic functional connectivity (FC) patterns between the DAN and other brain regions in tinnitus patients. Thirty-one patients with persistent tinnitus and thirty-three healthy controls were enrolled in this study. A group independent component analysis (ICA), degree centrality (DC) analysis, and seed-based FC analysis were conducted. In the group ICA, the tinnitus patients showed increased connectivity in the left superior parietal gyrus in the DAN compared to the healthy controls. Compared with the healthy controls, the tinnitus patients showed increased DC in the left inferior parietal gyrus and decreased DC in the left precuneus within the DAN. The clusters within the DAN with significant differences in the ICA or DC analysis between the tinnitus patients and the healthy controls were selected as regions of interest (ROIs) for seeds. The tinnitus patients exhibited significantly increased FC from the left superior parietal gyrus to several brain regions, including the left inferior parietal gyrus, the left superior marginal gyrus, and the right superior frontal gyrus, and decreased FC to the right anterior cingulate cortex. The tinnitus patients exhibited decreased FC from the left precuneus to the left inferior occipital gyrus, left calcarine cortex, and left superior frontal gyrus compared with the healthy controls. The findings of this study show that compared with healthy controls, tinnitus patients have altered functional connections not only within the DAN but also between the DAN and other brain regions. These results suggest that it may be possible to improve the disturbance and influence of tinnitus by regulating the DAN.http://dx.doi.org/10.1155/2021/2804533 |
| spellingShingle | Haimeng Hu Yining Lyu Shihong Li Zheng Yuan Chuntao Ye Zhao Han Guangwu Lin Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus Neural Plasticity |
| title | Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus |
| title_full | Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus |
| title_fullStr | Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus |
| title_full_unstemmed | Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus |
| title_short | Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus |
| title_sort | aberrant resting state functional connectivity of the dorsal attention network in tinnitus |
| url | http://dx.doi.org/10.1155/2021/2804533 |
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