T-regulatory cells for the treatment of autoimmune diseases
Autoimmune diseases result from imbalances in the immune system and disturbances in the mechanisms of immune tolerance. T-regulatory cells (Treg) are key factors in the formation of immune tolerance. Tregs modulate immune responses and repair processes, controlling the innate and adaptive immune sys...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1511671/full |
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| author | Marina S. Fisher Marina S. Fisher Sergey V. Sennikov Sergey V. Sennikov |
| author_facet | Marina S. Fisher Marina S. Fisher Sergey V. Sennikov Sergey V. Sennikov |
| author_sort | Marina S. Fisher |
| collection | DOAJ |
| description | Autoimmune diseases result from imbalances in the immune system and disturbances in the mechanisms of immune tolerance. T-regulatory cells (Treg) are key factors in the formation of immune tolerance. Tregs modulate immune responses and repair processes, controlling the innate and adaptive immune system. The use of Tregs in the treatment of autoimmune diseases began with the manipulation of endogenous Tregs using immunomodulatory drugs. Then, a method of adoptive transfer of Tregs grown in vitro was developed. Adoptive transfer of Tregs includes polyclonal Tregs with non-specific effects and antigen-specific Tregs in the form of CAR-Treg and TCR-Treg. This review discusses non-specific and antigen-specific approaches to the use of Tregs, their advantages, disadvantages, gaps in development, and future prospects. |
| format | Article |
| id | doaj-art-c126ae93af0f46c294240761e8c1ae09 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-c126ae93af0f46c294240761e8c1ae092025-02-04T06:31:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15116711511671T-regulatory cells for the treatment of autoimmune diseasesMarina S. Fisher0Marina S. Fisher1Sergey V. Sennikov2Sergey V. Sennikov3Laboratory of Molecular Immunology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Novosibirsk, RussiaLaboratory of Immune Engineering, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University under the Ministry of Health of the Russian Federation (Sechenov University), Moscow, RussiaLaboratory of Molecular Immunology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Novosibirsk, RussiaLaboratory of Immune Engineering, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University under the Ministry of Health of the Russian Federation (Sechenov University), Moscow, RussiaAutoimmune diseases result from imbalances in the immune system and disturbances in the mechanisms of immune tolerance. T-regulatory cells (Treg) are key factors in the formation of immune tolerance. Tregs modulate immune responses and repair processes, controlling the innate and adaptive immune system. The use of Tregs in the treatment of autoimmune diseases began with the manipulation of endogenous Tregs using immunomodulatory drugs. Then, a method of adoptive transfer of Tregs grown in vitro was developed. Adoptive transfer of Tregs includes polyclonal Tregs with non-specific effects and antigen-specific Tregs in the form of CAR-Treg and TCR-Treg. This review discusses non-specific and antigen-specific approaches to the use of Tregs, their advantages, disadvantages, gaps in development, and future prospects.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1511671/fullT-regulatory cellsautoimmune diseasesimmunological tolerancepolyclonal TregsCAR-TregTCR-Treg |
| spellingShingle | Marina S. Fisher Marina S. Fisher Sergey V. Sennikov Sergey V. Sennikov T-regulatory cells for the treatment of autoimmune diseases Frontiers in Immunology T-regulatory cells autoimmune diseases immunological tolerance polyclonal Tregs CAR-Treg TCR-Treg |
| title | T-regulatory cells for the treatment of autoimmune diseases |
| title_full | T-regulatory cells for the treatment of autoimmune diseases |
| title_fullStr | T-regulatory cells for the treatment of autoimmune diseases |
| title_full_unstemmed | T-regulatory cells for the treatment of autoimmune diseases |
| title_short | T-regulatory cells for the treatment of autoimmune diseases |
| title_sort | t regulatory cells for the treatment of autoimmune diseases |
| topic | T-regulatory cells autoimmune diseases immunological tolerance polyclonal Tregs CAR-Treg TCR-Treg |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1511671/full |
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