Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.

Age-related changes in DNA methylation have been implicated in cellular senescence and longevity, yet the causes and functional consequences of these variants remain unclear. To elucidate the role of age-related epigenetic changes in healthy ageing and potential longevity, we tested for association...

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Main Authors: Jordana T Bell, Pei-Chien Tsai, Tsun-Po Yang, Ruth Pidsley, James Nisbet, Daniel Glass, Massimo Mangino, Guangju Zhai, Feng Zhang, Ana Valdes, So-Youn Shin, Emma L Dempster, Robin M Murray, Elin Grundberg, Asa K Hedman, Alexandra Nica, Kerrin S Small, MuTHER Consortium, Emmanouil T Dermitzakis, Mark I McCarthy, Jonathan Mill, Tim D Spector, Panos Deloukas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002629&type=printable
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