The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection
The clinical evidences of variable epileptic propagation in occipital lobe epilepsy (OLE) have been demonstrated by several studies. However the exact localization of the epileptic focus sometimes represents a problem because of the rapid propagation to frontal, parietal, or temporal regions. Each w...
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Wiley
2015-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2015/872645 |
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| author | Francesco Latini Mats Hjortberg Håkan Aldskogius Mats Ryttlefors |
| author_facet | Francesco Latini Mats Hjortberg Håkan Aldskogius Mats Ryttlefors |
| author_sort | Francesco Latini |
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| description | The clinical evidences of variable epileptic propagation in occipital lobe epilepsy (OLE) have been demonstrated by several studies. However the exact localization of the epileptic focus sometimes represents a problem because of the rapid propagation to frontal, parietal, or temporal regions. Each white matter pathway close to the supposed initial focus can lead the propagation towards a specific direction, explaining the variable semiology of these rare epilepsy syndromes. Some new insights in occipital white matter anatomy are herein described by means of white matter dissection and compared to the classical epileptic patterns, mostly based on the central position of the primary visual cortex. The dissections showed a complex white matter architecture composed by vertical and longitudinal bundles, which are closely interconnected and segregated and are able to support specific high order functions with parallel bidirectional propagation of the electric signal. The same sublobar lesions may hyperactivate different white matter bundles reemphasizing the importance of the ictal semiology as a specific clinical demonstration of the subcortical networks recruited. Merging semiology, white matter anatomy, and electrophysiology may lead us to a better understanding of these complex syndromes and tailored therapeutic options based on individual white matter connectivity. |
| format | Article |
| id | doaj-art-c111b5fedba444f894a31390e5d34bd0 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-c111b5fedba444f894a31390e5d34bd02025-02-03T01:20:19ZengWileyBehavioural Neurology0953-41801875-85842015-01-01201510.1155/2015/872645872645The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter DissectionFrancesco Latini0Mats Hjortberg1Håkan Aldskogius2Mats Ryttlefors3Department of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, 75185 Uppsala, SwedenDepartment of Medical Cell Biology, Uppsala University, Uppsala, SwedenDepartment of Neuroscience, Regenerative Neurobiology, Uppsala University, Uppsala, SwedenDepartment of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, 75185 Uppsala, SwedenThe clinical evidences of variable epileptic propagation in occipital lobe epilepsy (OLE) have been demonstrated by several studies. However the exact localization of the epileptic focus sometimes represents a problem because of the rapid propagation to frontal, parietal, or temporal regions. Each white matter pathway close to the supposed initial focus can lead the propagation towards a specific direction, explaining the variable semiology of these rare epilepsy syndromes. Some new insights in occipital white matter anatomy are herein described by means of white matter dissection and compared to the classical epileptic patterns, mostly based on the central position of the primary visual cortex. The dissections showed a complex white matter architecture composed by vertical and longitudinal bundles, which are closely interconnected and segregated and are able to support specific high order functions with parallel bidirectional propagation of the electric signal. The same sublobar lesions may hyperactivate different white matter bundles reemphasizing the importance of the ictal semiology as a specific clinical demonstration of the subcortical networks recruited. Merging semiology, white matter anatomy, and electrophysiology may lead us to a better understanding of these complex syndromes and tailored therapeutic options based on individual white matter connectivity.http://dx.doi.org/10.1155/2015/872645 |
| spellingShingle | Francesco Latini Mats Hjortberg Håkan Aldskogius Mats Ryttlefors The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection Behavioural Neurology |
| title | The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection |
| title_full | The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection |
| title_fullStr | The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection |
| title_full_unstemmed | The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection |
| title_short | The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection |
| title_sort | classical pathways of occipital lobe epileptic propagation revised in the light of white matter dissection |
| url | http://dx.doi.org/10.1155/2015/872645 |
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