Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery
Background. The receptor for advanced glycation end products (RAGE) is an inflammation-perpetuating receptor, and soluble RAGE (sRAGE) is a marker of cellular RAGE expression. This study investigated whether raised plasma levels prior to surgery of sRAGE or S100A8/A9 (a RAGE ligand) were associated...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/496031 |
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| author | Benedict C. Creagh-Brown Gregory J. Quinlan Lauren R. Hector Timothy W. Evans Anne Burke-Gaffney |
| author_facet | Benedict C. Creagh-Brown Gregory J. Quinlan Lauren R. Hector Timothy W. Evans Anne Burke-Gaffney |
| author_sort | Benedict C. Creagh-Brown |
| collection | DOAJ |
| description | Background. The receptor for advanced glycation end products (RAGE) is an inflammation-perpetuating receptor, and soluble RAGE (sRAGE) is a marker of cellular RAGE expression. This study investigated whether raised plasma levels prior to surgery of sRAGE or S100A8/A9 (a RAGE ligand) were associated with longer duration of hospital care in patients undergoing cardiac surgery necessitating cardiopulmonary bypass. Methods. Patients (n=130) undergoing elective cardiac surgery were enrolled prospectively. Plasma sRAGE and S100A8/A9 concentrations were measured before and 2 h after surgery. Results. Preoperative plasma sRAGE increased significantly (P<0.0001) from 1.06 ng/mL (IQR, 0.72–1.76) to 1.93 ng/mL (IQR, 1.14–2.63) 2 h postoperatively. Plasma S100A8/9 was also significantly (P<0.0001) higher 2 h postoperatively (2.37 μg/mL, IQR, 1.81–3.05) compared to pre-operative levels (0.41 μg/mL, IQR, 0.2–0.65). Preoperative sRAGE, but not S100A8/A9, was positively and significantly correlated with duration of critical illness (r=0.3, P=0.0007) and length of hospital stay (LOS; r=0.31, P<0.0005). Multivariate binary logistic regression showed preoperative sRAGE to be, statistically, an independent predictor of greater than median duration of critical illness (odds ratio 16.6, P=0.014) and to be, statistically, the strongest independent predictor of hospital LOS. Conclusion. Higher preoperative plasma sRAGE levels were associated with prolonged duration of care in adults undergoing cardiac surgery requiring cardiopulmonary bypass. |
| format | Article |
| id | doaj-art-c1086d8055054b5f92f29ad1ea39ec3c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c1086d8055054b5f92f29ad1ea39ec3c2025-02-03T05:51:03ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/496031496031Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac SurgeryBenedict C. Creagh-Brown0Gregory J. Quinlan1Lauren R. Hector2Timothy W. Evans3Anne Burke-Gaffney4Unit of Critical Care, Respiratory Science, National Heart and Lung Institute Division (NHLI), Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UKUnit of Critical Care, Respiratory Science, National Heart and Lung Institute Division (NHLI), Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UKUnit of Critical Care, Respiratory Science, National Heart and Lung Institute Division (NHLI), Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UKUnit of Critical Care, Respiratory Science, National Heart and Lung Institute Division (NHLI), Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UKUnit of Critical Care, Respiratory Science, National Heart and Lung Institute Division (NHLI), Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UKBackground. The receptor for advanced glycation end products (RAGE) is an inflammation-perpetuating receptor, and soluble RAGE (sRAGE) is a marker of cellular RAGE expression. This study investigated whether raised plasma levels prior to surgery of sRAGE or S100A8/A9 (a RAGE ligand) were associated with longer duration of hospital care in patients undergoing cardiac surgery necessitating cardiopulmonary bypass. Methods. Patients (n=130) undergoing elective cardiac surgery were enrolled prospectively. Plasma sRAGE and S100A8/A9 concentrations were measured before and 2 h after surgery. Results. Preoperative plasma sRAGE increased significantly (P<0.0001) from 1.06 ng/mL (IQR, 0.72–1.76) to 1.93 ng/mL (IQR, 1.14–2.63) 2 h postoperatively. Plasma S100A8/9 was also significantly (P<0.0001) higher 2 h postoperatively (2.37 μg/mL, IQR, 1.81–3.05) compared to pre-operative levels (0.41 μg/mL, IQR, 0.2–0.65). Preoperative sRAGE, but not S100A8/A9, was positively and significantly correlated with duration of critical illness (r=0.3, P=0.0007) and length of hospital stay (LOS; r=0.31, P<0.0005). Multivariate binary logistic regression showed preoperative sRAGE to be, statistically, an independent predictor of greater than median duration of critical illness (odds ratio 16.6, P=0.014) and to be, statistically, the strongest independent predictor of hospital LOS. Conclusion. Higher preoperative plasma sRAGE levels were associated with prolonged duration of care in adults undergoing cardiac surgery requiring cardiopulmonary bypass.http://dx.doi.org/10.1155/2013/496031 |
| spellingShingle | Benedict C. Creagh-Brown Gregory J. Quinlan Lauren R. Hector Timothy W. Evans Anne Burke-Gaffney Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery Mediators of Inflammation |
| title | Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery |
| title_full | Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery |
| title_fullStr | Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery |
| title_full_unstemmed | Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery |
| title_short | Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery |
| title_sort | association between preoperative plasma srage levels and recovery from cardiac surgery |
| url | http://dx.doi.org/10.1155/2013/496031 |
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