A novel multi-omics approach for identifying key genes in intervertebral disc degeneration

A novel multi-omics approach for identifying key genes in intervertebral disc degeneration

Many different cell types and complex molecular pathways are involved in intervertebral disc degeneration (IDD). We used a multi-omics approach combining single-cell RNA sequencing (scRNA-seq), differential gene expression analysis, and Mendelian randomization (MR) to clarify the underlying genetic...

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Bibliographic Details
Main Authors: Xuan Zhao, Qijun Wang, Shuaikang Wang, Wei Wang, Xiaolong Chen, Shibao Lu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:SLAS Technology
Subjects:
Intervertebral disc degeneration
Programmed cell death
Mendelian randomization
Single cell analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2472630324001055
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