Suppression of Tumor Angiogenesis by Nonsteroidal Anti-Inflammatory Drugs: A New Function for Old Drugs
There is solid epidemiological evidence demonstrating that the regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing colorectal cancer, and to a lesser extent gastric and esophageal cancers[1]. Importantly, NSAIDs suppress colon polyp formation and progression i...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2001-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2001.396 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545602027651072 |
|---|---|
| author | Curzio Raegg Olivier Dormond |
| author_facet | Curzio Raegg Olivier Dormond |
| author_sort | Curzio Raegg |
| collection | DOAJ |
| description | There is solid epidemiological evidence demonstrating that the regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing colorectal cancer, and to a lesser extent gastric and esophageal cancers[1]. Importantly, NSAIDs suppress colon polyp formation and progression in patients diagnosed with familial adenomatous polyposis coli (APC)[2]. In many animal studies, NSAIDs have been shown to prevent tumor formation and slow tumor progression, thus confirming and extending the clinical observations[3,4,5]. Recent findings have demonstrated that NSAIDs inhibit angiogenesis, suggesting that the tumor suppressive activity of these drugs may be due, at least in part, to their ability to inhibit tumor angiogenesis[6]. The study of the mechanism by which NSAIDs suppress tumor angiogenesis, is matter of intense research. |
| format | Article |
| id | doaj-art-c0feb35525de45e3b7de730729a71310 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-c0feb35525de45e3b7de730729a713102025-02-03T07:25:28ZengWileyThe Scientific World Journal1537-744X2001-01-01180881110.1100/tsw.2001.396Suppression of Tumor Angiogenesis by Nonsteroidal Anti-Inflammatory Drugs: A New Function for Old DrugsCurzio Raegg0Olivier Dormond1Laboratory of the Centre Pluridisciplinaire d'Oncologie, University of Lausanne Medical School, Swiss Institute for Experimental Cancer Research, Epalinges, SwitzerlandLaboratory of the Centre Pluridisciplinaire d'Oncologie, University of Lausanne Medical School, Swiss Institute for Experimental Cancer Research, Epalinges, SwitzerlandThere is solid epidemiological evidence demonstrating that the regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing colorectal cancer, and to a lesser extent gastric and esophageal cancers[1]. Importantly, NSAIDs suppress colon polyp formation and progression in patients diagnosed with familial adenomatous polyposis coli (APC)[2]. In many animal studies, NSAIDs have been shown to prevent tumor formation and slow tumor progression, thus confirming and extending the clinical observations[3,4,5]. Recent findings have demonstrated that NSAIDs inhibit angiogenesis, suggesting that the tumor suppressive activity of these drugs may be due, at least in part, to their ability to inhibit tumor angiogenesis[6]. The study of the mechanism by which NSAIDs suppress tumor angiogenesis, is matter of intense research.http://dx.doi.org/10.1100/tsw.2001.396 |
| spellingShingle | Curzio Raegg Olivier Dormond Suppression of Tumor Angiogenesis by Nonsteroidal Anti-Inflammatory Drugs: A New Function for Old Drugs The Scientific World Journal |
| title | Suppression of Tumor Angiogenesis by Nonsteroidal Anti-Inflammatory Drugs: A New Function for Old Drugs |
| title_full | Suppression of Tumor Angiogenesis by Nonsteroidal Anti-Inflammatory Drugs: A New Function for Old Drugs |
| title_fullStr | Suppression of Tumor Angiogenesis by Nonsteroidal Anti-Inflammatory Drugs: A New Function for Old Drugs |
| title_full_unstemmed | Suppression of Tumor Angiogenesis by Nonsteroidal Anti-Inflammatory Drugs: A New Function for Old Drugs |
| title_short | Suppression of Tumor Angiogenesis by Nonsteroidal Anti-Inflammatory Drugs: A New Function for Old Drugs |
| title_sort | suppression of tumor angiogenesis by nonsteroidal anti inflammatory drugs a new function for old drugs |
| url | http://dx.doi.org/10.1100/tsw.2001.396 |
| work_keys_str_mv | AT curzioraegg suppressionoftumorangiogenesisbynonsteroidalantiinflammatorydrugsanewfunctionforolddrugs AT olivierdormond suppressionoftumorangiogenesisbynonsteroidalantiinflammatorydrugsanewfunctionforolddrugs |