An in‐cell helicase reporter system for quantifying DDX3X and DDX3Y activities

An in‐cell helicase reporter system for quantifying DDX3X and DDX3Y activities

Abstract Genome sequencing has identified numerous mutations in the DEAD‐box RNA helicases, DDX3X and DDX3Y, associated with cancer and other diseases, but monitoring of their functional consequences remains a challenge. Conventional helicase assays are laborious, often technically difficult, and ar...

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Bibliographic Details
Main Authors: Zhi Sheng Poh, James Chia Wei Tan, Brandon Han Siang Wong, Kottaiswamy Amuthavalli, Holy Kristanti, Suat Hoon Tan, Nicholas Francis Grigoropoulos, Navin Kumar Verma
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Bioengineering & Translational Medicine
Subjects:
cancer
DDX3X
luciferase
reporter cells
RNA helicase
Online Access:https://doi.org/10.1002/btm2.10720
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