Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation
Abstract Ciprofol, a novel γ-aminobutyric acid receptor agonist, outperforms propofol with minimal cardiovascular effects, higher potency, reduced injection pain, and a broader safety margin. Despite these advantages, ciprofol’s clinical research is still emerging. This study compares the median eff...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-85968-2 |
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| author | Min Liao Xiao-Ru Wu Jia-Ning Hu Xing-Zhou Lin Tang‑yuan‑meng Zhao Hu Sun |
| author_facet | Min Liao Xiao-Ru Wu Jia-Ning Hu Xing-Zhou Lin Tang‑yuan‑meng Zhao Hu Sun |
| author_sort | Min Liao |
| collection | DOAJ |
| description | Abstract Ciprofol, a novel γ-aminobutyric acid receptor agonist, outperforms propofol with minimal cardiovascular effects, higher potency, reduced injection pain, and a broader safety margin. Despite these advantages, ciprofol’s clinical research is still emerging. This study compares the median effective dose (ED50) and adverse reactions of ciprofol and propofol, in conjunction with sufentanil, for suppressing cardiovascular responses during tracheal intubation. Fifty-three adult patients scheduled for tracheal intubation under general anesthesia were enrolled and randomly assigned to receive either ciprofol (Group C) or propofol (Group P), according to a random number table. Tracheal intubation was performed using a standardized laryngoscope and endotracheal tube. The Dixon’s up-and-down method was employed to determine the ED50 and 95% effective dose (ED95) of ciprofol and propofol in inhibiting cardiovascular responses during tracheal intubation. Based on the pilot study, the initial dose for ciprofol was set at 0.35 mg/kg (with a 0.01 mg/kg increment) and for propofol at 2.0 mg/kg (with a 0.1 mg/kg increment). Probit analysis was applied to derive dose-response curves, while adverse reactions were continuously monitored. A total of 54 participants were included, with 24 in group C (1 excluded) and 30 in group P. Probit analysis revealed that the ED50 of ciprofol for inhibiting cardiovascular responses to tracheal intubation were 0.326 mg/kg (95% CI 0.304–0.337 mg/kg), and for propofol, 1.541 mg/kg (95% CI 1.481–1.599 mg/kg). The heart rate in group P was significantly higher than the group C at 1 minute (p = 0.026) and 3 minutes (p = 0.016) post-intubation. Systolic and diastolic blood pressures (SBP and DBP) decreased significantly before and after intubation compared to baseline values in both groups (p< 0.05). Group C experienced significantly less injection pain (p = 0.001), although the incidence of other adverse effects was not statistically different between groups (p > 0.05). Clinical Trial Registration: hppts://ClinicalTrials.gov; Identifier: NCT06095570(18/10/2023). |
| format | Article |
| id | doaj-art-c0f94bad5ffa4751821abb7f23957f0a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-c0f94bad5ffa4751821abb7f23957f0a2025-01-19T12:24:21ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-85968-2Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubationMin Liao0Xiao-Ru Wu1Jia-Ning Hu2Xing-Zhou Lin3Tang‑yuan‑meng Zhao4Hu Sun5The Second Affiliated Hospital of Hainan Medical UniversityThe Second Affiliated Hospital of Hainan Medical UniversityThe Second Affiliated Hospital of Hainan Medical UniversityThe Second Affiliated Hospital of Hainan Medical UniversityWest China Hospital, Sichuan UniversityThe Second Affiliated Hospital of Hainan Medical UniversityAbstract Ciprofol, a novel γ-aminobutyric acid receptor agonist, outperforms propofol with minimal cardiovascular effects, higher potency, reduced injection pain, and a broader safety margin. Despite these advantages, ciprofol’s clinical research is still emerging. This study compares the median effective dose (ED50) and adverse reactions of ciprofol and propofol, in conjunction with sufentanil, for suppressing cardiovascular responses during tracheal intubation. Fifty-three adult patients scheduled for tracheal intubation under general anesthesia were enrolled and randomly assigned to receive either ciprofol (Group C) or propofol (Group P), according to a random number table. Tracheal intubation was performed using a standardized laryngoscope and endotracheal tube. The Dixon’s up-and-down method was employed to determine the ED50 and 95% effective dose (ED95) of ciprofol and propofol in inhibiting cardiovascular responses during tracheal intubation. Based on the pilot study, the initial dose for ciprofol was set at 0.35 mg/kg (with a 0.01 mg/kg increment) and for propofol at 2.0 mg/kg (with a 0.1 mg/kg increment). Probit analysis was applied to derive dose-response curves, while adverse reactions were continuously monitored. A total of 54 participants were included, with 24 in group C (1 excluded) and 30 in group P. Probit analysis revealed that the ED50 of ciprofol for inhibiting cardiovascular responses to tracheal intubation were 0.326 mg/kg (95% CI 0.304–0.337 mg/kg), and for propofol, 1.541 mg/kg (95% CI 1.481–1.599 mg/kg). The heart rate in group P was significantly higher than the group C at 1 minute (p = 0.026) and 3 minutes (p = 0.016) post-intubation. Systolic and diastolic blood pressures (SBP and DBP) decreased significantly before and after intubation compared to baseline values in both groups (p< 0.05). Group C experienced significantly less injection pain (p = 0.001), although the incidence of other adverse effects was not statistically different between groups (p > 0.05). Clinical Trial Registration: hppts://ClinicalTrials.gov; Identifier: NCT06095570(18/10/2023).https://doi.org/10.1038/s41598-025-85968-2PropofolCiprofolTracheal intubationCardiovascular responseDose-response relationship |
| spellingShingle | Min Liao Xiao-Ru Wu Jia-Ning Hu Xing-Zhou Lin Tang‑yuan‑meng Zhao Hu Sun Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation Scientific Reports Propofol Ciprofol Tracheal intubation Cardiovascular response Dose-response relationship |
| title | Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation |
| title_full | Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation |
| title_fullStr | Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation |
| title_full_unstemmed | Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation |
| title_short | Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation |
| title_sort | comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation |
| topic | Propofol Ciprofol Tracheal intubation Cardiovascular response Dose-response relationship |
| url | https://doi.org/10.1038/s41598-025-85968-2 |
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