Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient
Immune thrombocytopenia (ITP) is characterized by isolated thrombocytopenia of unclear etiology. We present a unique case of an 8-year-old girl with chronic ITP who was subsequently diagnosed with T-lymphoblastic lymphoma at age 11. The clinical course was complicated by the occurrence of nonepilept...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/1425151 |
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| author | Ryan A. Denu Daniel R. Matson Matthew J. Davis Natalie J. Tedford Christine E. Brichta Carol A. Diamond Margo L. Hoover-Regan |
| author_facet | Ryan A. Denu Daniel R. Matson Matthew J. Davis Natalie J. Tedford Christine E. Brichta Carol A. Diamond Margo L. Hoover-Regan |
| author_sort | Ryan A. Denu |
| collection | DOAJ |
| description | Immune thrombocytopenia (ITP) is characterized by isolated thrombocytopenia of unclear etiology. We present a unique case of an 8-year-old girl with chronic ITP who was subsequently diagnosed with T-lymphoblastic lymphoma at age 11. The clinical course was complicated by the occurrence of nonepileptiform events with bizarre behavior changes following the administration of nelarabine and intrathecal and high-dose systemic methotrexate. This case highlights an unusual co-occurrence of hematologic malignancy and chronic ITP in an otherwise healthy child. We speculate that underlying genetic or immunologic lesions may predispose a subset of pediatric ITP patients to the development of hematologic malignancies. |
| format | Article |
| id | doaj-art-c0ef9fd392a6412ab427fe3432acde33 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-c0ef9fd392a6412ab427fe3432acde332025-02-03T01:00:21ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/14251511425151Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric PatientRyan A. Denu0Daniel R. Matson1Matthew J. Davis2Natalie J. Tedford3Christine E. Brichta4Carol A. Diamond5Margo L. Hoover-Regan6Medical Scientist Training Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USADepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USACarbone Cancer Center, University of Wisconsin, Madison, WI, USADepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USADepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USACarbone Cancer Center, University of Wisconsin, Madison, WI, USACarbone Cancer Center, University of Wisconsin, Madison, WI, USAImmune thrombocytopenia (ITP) is characterized by isolated thrombocytopenia of unclear etiology. We present a unique case of an 8-year-old girl with chronic ITP who was subsequently diagnosed with T-lymphoblastic lymphoma at age 11. The clinical course was complicated by the occurrence of nonepileptiform events with bizarre behavior changes following the administration of nelarabine and intrathecal and high-dose systemic methotrexate. This case highlights an unusual co-occurrence of hematologic malignancy and chronic ITP in an otherwise healthy child. We speculate that underlying genetic or immunologic lesions may predispose a subset of pediatric ITP patients to the development of hematologic malignancies.http://dx.doi.org/10.1155/2019/1425151 |
| spellingShingle | Ryan A. Denu Daniel R. Matson Matthew J. Davis Natalie J. Tedford Christine E. Brichta Carol A. Diamond Margo L. Hoover-Regan Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient Case Reports in Hematology |
| title | Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient |
| title_full | Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient |
| title_fullStr | Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient |
| title_full_unstemmed | Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient |
| title_short | Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient |
| title_sort | association of immune thrombocytopenia and t lymphoblastic lymphoma in a pediatric patient |
| url | http://dx.doi.org/10.1155/2019/1425151 |
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