Anticoagulant Related Nephropathy Induced by Dabigatran
We describe a case of biopsy-proven dabigatran related nephropathy in a patient without underlying IgA nephropathy. To date, dabigatran related nephropathy was only reported in patients with concurrent or undiagnosed IgA nephropathy, suggesting that it may predispose patients to dabigatran associate...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2018/7381505 |
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| author | Nazia Sharfuddin Mahra Nourbakhsh Alan Box Hallgrimur Benediktsson Daniel A. Muruve |
| author_facet | Nazia Sharfuddin Mahra Nourbakhsh Alan Box Hallgrimur Benediktsson Daniel A. Muruve |
| author_sort | Nazia Sharfuddin |
| collection | DOAJ |
| description | We describe a case of biopsy-proven dabigatran related nephropathy in a patient without underlying IgA nephropathy. To date, dabigatran related nephropathy was only reported in patients with concurrent or undiagnosed IgA nephropathy, suggesting that it may predispose patients to dabigatran associated injury. The patient is an 81-year-old woman with multiple medical comorbidities, including nonvalvular atrial fibrillation, who was anticoagulated with dabigatran. She presented to hospital with acute kidney injury in the setting of volume overload. Her estimated glomerular filtration rate decreased from a baseline of 57 mL/min/1.73 m2 to 4 mL/min/1.73 m2, necessitating hemodialysis. Renal ultrasound findings, fractional excretion of sodium, and urinalysis suggested acute kidney injury. Renal biopsy showed acute tubular injury, tubular red blood cell casts, and an absence of active glomerulonephritis, similar to the pathological findings of warfarin related nephropathy. A diagnosis of anticoagulant related nephropathy secondary to dabigatran was therefore established. This case demonstrates that dabigatran, like warfarin, may increase tubular bleeding risk in patients, irrespective of underlying kidney or glomerular disease. |
| format | Article |
| id | doaj-art-c0ed6cd79766407792fd3d49fa428856 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-c0ed6cd79766407792fd3d49fa4288562025-02-03T06:01:34ZengWileyCase Reports in Nephrology2090-66412090-665X2018-01-01201810.1155/2018/73815057381505Anticoagulant Related Nephropathy Induced by DabigatranNazia Sharfuddin0Mahra Nourbakhsh1Alan Box2Hallgrimur Benediktsson3Daniel A. Muruve4Department of Medicine, University of Calgary, CanadaDepartment of Pathology & Laboratory Medicine, University of Calgary, CanadaDepartment of Pathology & Laboratory Medicine, University of Calgary, CanadaDepartment of Pathology & Laboratory Medicine, University of Calgary, CanadaDepartment of Medicine, University of Calgary, CanadaWe describe a case of biopsy-proven dabigatran related nephropathy in a patient without underlying IgA nephropathy. To date, dabigatran related nephropathy was only reported in patients with concurrent or undiagnosed IgA nephropathy, suggesting that it may predispose patients to dabigatran associated injury. The patient is an 81-year-old woman with multiple medical comorbidities, including nonvalvular atrial fibrillation, who was anticoagulated with dabigatran. She presented to hospital with acute kidney injury in the setting of volume overload. Her estimated glomerular filtration rate decreased from a baseline of 57 mL/min/1.73 m2 to 4 mL/min/1.73 m2, necessitating hemodialysis. Renal ultrasound findings, fractional excretion of sodium, and urinalysis suggested acute kidney injury. Renal biopsy showed acute tubular injury, tubular red blood cell casts, and an absence of active glomerulonephritis, similar to the pathological findings of warfarin related nephropathy. A diagnosis of anticoagulant related nephropathy secondary to dabigatran was therefore established. This case demonstrates that dabigatran, like warfarin, may increase tubular bleeding risk in patients, irrespective of underlying kidney or glomerular disease.http://dx.doi.org/10.1155/2018/7381505 |
| spellingShingle | Nazia Sharfuddin Mahra Nourbakhsh Alan Box Hallgrimur Benediktsson Daniel A. Muruve Anticoagulant Related Nephropathy Induced by Dabigatran Case Reports in Nephrology |
| title | Anticoagulant Related Nephropathy Induced by Dabigatran |
| title_full | Anticoagulant Related Nephropathy Induced by Dabigatran |
| title_fullStr | Anticoagulant Related Nephropathy Induced by Dabigatran |
| title_full_unstemmed | Anticoagulant Related Nephropathy Induced by Dabigatran |
| title_short | Anticoagulant Related Nephropathy Induced by Dabigatran |
| title_sort | anticoagulant related nephropathy induced by dabigatran |
| url | http://dx.doi.org/10.1155/2018/7381505 |
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