The pathogenesis of scleroderma
Systemic sclerosis (SSc) results from the complex interplay between the immune system, vasculature and tissue-repair mechanisms. Endothelial injury is the prime event; environmental triggers in the susceptible individual trigger the pathologic process, which translates into fibrosis. The outcome of...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2017;volume=12;issue=6;spage=142;epage=148;aulast=Gupta |
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| _version_ | 1832568802443788288 |
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| author | Latika Gupta Sakir Ahmed Abhishek Zanwar |
| author_facet | Latika Gupta Sakir Ahmed Abhishek Zanwar |
| author_sort | Latika Gupta |
| collection | DOAJ |
| description | Systemic sclerosis (SSc) results from the complex interplay between the immune system, vasculature and tissue-repair mechanisms. Endothelial injury is the prime event; environmental triggers in the susceptible individual trigger the pathologic process, which translates into fibrosis. The outcome of SSc is not as bleak as it looked a couple of decades ago. With a greater understanding of older pathways, as well as elucidation of newer ones, the potential targets to block and even reverse fibrosis bring around a revolution in the way we look at this once dreaded disease. |
| format | Article |
| id | doaj-art-c0e42853b6a64f908ad9e267ef1b0879 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-c0e42853b6a64f908ad9e267ef1b08792025-02-03T00:25:38ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012017-01-01126142148The pathogenesis of sclerodermaLatika GuptaSakir AhmedAbhishek ZanwarSystemic sclerosis (SSc) results from the complex interplay between the immune system, vasculature and tissue-repair mechanisms. Endothelial injury is the prime event; environmental triggers in the susceptible individual trigger the pathologic process, which translates into fibrosis. The outcome of SSc is not as bleak as it looked a couple of decades ago. With a greater understanding of older pathways, as well as elucidation of newer ones, the potential targets to block and even reverse fibrosis bring around a revolution in the way we look at this once dreaded disease.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2017;volume=12;issue=6;spage=142;epage=148;aulast=GuptaEndothelial dysfunctionendothelial progenitor cellsendothelial to mesenchymal transitionfibrosishypoxiaserotonintransforming growth factor-beta |
| spellingShingle | Latika Gupta Sakir Ahmed Abhishek Zanwar The pathogenesis of scleroderma Indian Journal of Rheumatology Endothelial dysfunction endothelial progenitor cells endothelial to mesenchymal transition fibrosis hypoxia serotonin transforming growth factor-beta |
| title | The pathogenesis of scleroderma |
| title_full | The pathogenesis of scleroderma |
| title_fullStr | The pathogenesis of scleroderma |
| title_full_unstemmed | The pathogenesis of scleroderma |
| title_short | The pathogenesis of scleroderma |
| title_sort | pathogenesis of scleroderma |
| topic | Endothelial dysfunction endothelial progenitor cells endothelial to mesenchymal transition fibrosis hypoxia serotonin transforming growth factor-beta |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2017;volume=12;issue=6;spage=142;epage=148;aulast=Gupta |
| work_keys_str_mv | AT latikagupta thepathogenesisofscleroderma AT sakirahmed thepathogenesisofscleroderma AT abhishekzanwar thepathogenesisofscleroderma AT latikagupta pathogenesisofscleroderma AT sakirahmed pathogenesisofscleroderma AT abhishekzanwar pathogenesisofscleroderma |