The role of semaphorin 3A in the pathogenesis and progression of Alzheimer’s disease and other aging-related diseases: A comprehensive review
Aging serves as a pivotal factor in the etiology of numerous diseases, such as Alzheimer's disease (AD), Parkinson's disease, diabetes, osteoarthritis, atherosclerosis and aging-related macular degeneration. Notably, these diseases often interact with AD through various pathways, facilitat...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825001574 |
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| author | Jiayu Yuan Rui Huang Jianfei Nao Xiaoyu Dong |
| author_facet | Jiayu Yuan Rui Huang Jianfei Nao Xiaoyu Dong |
| author_sort | Jiayu Yuan |
| collection | DOAJ |
| description | Aging serves as a pivotal factor in the etiology of numerous diseases, such as Alzheimer's disease (AD), Parkinson's disease, diabetes, osteoarthritis, atherosclerosis and aging-related macular degeneration. Notably, these diseases often interact with AD through various pathways, facilitating the onset or progression of one another. Semaphorin 3 A (Sema3A), a protein that is essential for axonal guidance during neural development, has recently been identified as a novel regulator in the pathogenesis and progression of multiple aging-related diseases. This article provides a comprehensive review of the expression patterns and mechanisms of action of Sema3A in these diseases. Specifically, Sema3A influences the occurrence and development of aging-related diseases by participating in oxidative stress, inflammatory responses, apoptosis, and synaptic plasticity. Therefore, therapeutic strategies targeting Sema3A present promising avenues for delaying the progression of aging-related diseases and offer novel insights and strategies for their treatment. |
| format | Article |
| id | doaj-art-c0e2344427f94e6cbe06bd1b53e3bb25 |
| institution | OA Journals |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-c0e2344427f94e6cbe06bd1b53e3bb252025-08-20T02:30:14ZengElsevierPharmacological Research1096-11862025-05-0121510773210.1016/j.phrs.2025.107732The role of semaphorin 3A in the pathogenesis and progression of Alzheimer’s disease and other aging-related diseases: A comprehensive reviewJiayu Yuan0Rui Huang1Jianfei Nao2Xiaoyu Dong3Department of Neurology, Shengjing Hospital of China Medical University, No. 36 Sanhao street, Heping District, Shenyang, Liaoning 110000, ChinaDepartment of Neurology, Shengjing Hospital of China Medical University, No. 36 Sanhao street, Heping District, Shenyang, Liaoning 110000, ChinaCorresponding authors.; Department of Neurology, Shengjing Hospital of China Medical University, No. 36 Sanhao street, Heping District, Shenyang, Liaoning 110000, ChinaCorresponding authors.; Department of Neurology, Shengjing Hospital of China Medical University, No. 36 Sanhao street, Heping District, Shenyang, Liaoning 110000, ChinaAging serves as a pivotal factor in the etiology of numerous diseases, such as Alzheimer's disease (AD), Parkinson's disease, diabetes, osteoarthritis, atherosclerosis and aging-related macular degeneration. Notably, these diseases often interact with AD through various pathways, facilitating the onset or progression of one another. Semaphorin 3 A (Sema3A), a protein that is essential for axonal guidance during neural development, has recently been identified as a novel regulator in the pathogenesis and progression of multiple aging-related diseases. This article provides a comprehensive review of the expression patterns and mechanisms of action of Sema3A in these diseases. Specifically, Sema3A influences the occurrence and development of aging-related diseases by participating in oxidative stress, inflammatory responses, apoptosis, and synaptic plasticity. Therefore, therapeutic strategies targeting Sema3A present promising avenues for delaying the progression of aging-related diseases and offer novel insights and strategies for their treatment.http://www.sciencedirect.com/science/article/pii/S1043661825001574Semaphorin 3 AAlzheimer’s diseaseParkinson’s diseaseAtherosclerosisType 2 diabetes mellitus |
| spellingShingle | Jiayu Yuan Rui Huang Jianfei Nao Xiaoyu Dong The role of semaphorin 3A in the pathogenesis and progression of Alzheimer’s disease and other aging-related diseases: A comprehensive review Pharmacological Research Semaphorin 3 A Alzheimer’s disease Parkinson’s disease Atherosclerosis Type 2 diabetes mellitus |
| title | The role of semaphorin 3A in the pathogenesis and progression of Alzheimer’s disease and other aging-related diseases: A comprehensive review |
| title_full | The role of semaphorin 3A in the pathogenesis and progression of Alzheimer’s disease and other aging-related diseases: A comprehensive review |
| title_fullStr | The role of semaphorin 3A in the pathogenesis and progression of Alzheimer’s disease and other aging-related diseases: A comprehensive review |
| title_full_unstemmed | The role of semaphorin 3A in the pathogenesis and progression of Alzheimer’s disease and other aging-related diseases: A comprehensive review |
| title_short | The role of semaphorin 3A in the pathogenesis and progression of Alzheimer’s disease and other aging-related diseases: A comprehensive review |
| title_sort | role of semaphorin 3a in the pathogenesis and progression of alzheimer s disease and other aging related diseases a comprehensive review |
| topic | Semaphorin 3 A Alzheimer’s disease Parkinson’s disease Atherosclerosis Type 2 diabetes mellitus |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825001574 |
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