Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.
In this study, the polyphenol content and the antioxidant and antimicrobial activities of hydroethanolic (MVE) and hydroacetonic (MVA) leaf extracts of Marrubium vulgare L. were examined. The results indicated that the total phenolic content was higher in MVA (112.09 ± 4.77 mg GAE/DW) compared to MV...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2021/7011493 |
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| author | Ibrahim Mssillou Abdelkrim Agour Noureddine Hamamouch Badiaa Lyoussi Elhoussine Derwich |
| author_facet | Ibrahim Mssillou Abdelkrim Agour Noureddine Hamamouch Badiaa Lyoussi Elhoussine Derwich |
| author_sort | Ibrahim Mssillou |
| collection | DOAJ |
| description | In this study, the polyphenol content and the antioxidant and antimicrobial activities of hydroethanolic (MVE) and hydroacetonic (MVA) leaf extracts of Marrubium vulgare L. were examined. The results indicated that the total phenolic content was higher in MVA (112.09 ± 4.77 mg GAE/DW) compared to MVE extract (98.77 ± 1.68 mg GAE/DW). The total flavonoid content was also higher in MVA extract (21.08 ± 0.38 mg QE/g DW) compared to MVE (17.65 ± 0.73 mg QE/g DW). Analysis of the chemical composition revealed the presence of 13 compounds with a total of 96.14%, with the major compound being malic acid (22.57%). Both extracts possess a good total antioxidant activity. DPPH and FRAP assays indicated that the MVE extract possesses a better antioxidant activity, with IC50 = 52.04 µg/mL ± 0.2 and EC50 of 4.51 ± 0.5 mg/mL, compared to MVA extract (IC50 = 60.57 ± 0.6 µg/mL and EC50 of 6.43 ± 0.0411 mg/mL). Moreover, both extracts exhibited strong antimicrobial activity against certain nosocomial strains as indicted by the MIC values, which ranged between 0.93 mg/mL and 10 mg/mL. Taken together, these results reveal the importance of M. vulgare as a natural antioxidant with important antimicrobial activity. |
| format | Article |
| id | doaj-art-c0c0a27c320f4f4ea081ec9db3ab0c77 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-c0c0a27c320f4f4ea081ec9db3ab0c772025-02-03T01:25:24ZengWileyThe Scientific World Journal1537-744X2021-01-01202110.1155/2021/7011493Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.Ibrahim Mssillou0Abdelkrim Agour1Noureddine Hamamouch2Badiaa Lyoussi3Elhoussine Derwich4Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ)Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ)Laboratory of Biotechnology and Plant PhysiologyLaboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ)Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ)In this study, the polyphenol content and the antioxidant and antimicrobial activities of hydroethanolic (MVE) and hydroacetonic (MVA) leaf extracts of Marrubium vulgare L. were examined. The results indicated that the total phenolic content was higher in MVA (112.09 ± 4.77 mg GAE/DW) compared to MVE extract (98.77 ± 1.68 mg GAE/DW). The total flavonoid content was also higher in MVA extract (21.08 ± 0.38 mg QE/g DW) compared to MVE (17.65 ± 0.73 mg QE/g DW). Analysis of the chemical composition revealed the presence of 13 compounds with a total of 96.14%, with the major compound being malic acid (22.57%). Both extracts possess a good total antioxidant activity. DPPH and FRAP assays indicated that the MVE extract possesses a better antioxidant activity, with IC50 = 52.04 µg/mL ± 0.2 and EC50 of 4.51 ± 0.5 mg/mL, compared to MVA extract (IC50 = 60.57 ± 0.6 µg/mL and EC50 of 6.43 ± 0.0411 mg/mL). Moreover, both extracts exhibited strong antimicrobial activity against certain nosocomial strains as indicted by the MIC values, which ranged between 0.93 mg/mL and 10 mg/mL. Taken together, these results reveal the importance of M. vulgare as a natural antioxidant with important antimicrobial activity.http://dx.doi.org/10.1155/2021/7011493 |
| spellingShingle | Ibrahim Mssillou Abdelkrim Agour Noureddine Hamamouch Badiaa Lyoussi Elhoussine Derwich Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L. The Scientific World Journal |
| title | Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L. |
| title_full | Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L. |
| title_fullStr | Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L. |
| title_full_unstemmed | Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L. |
| title_short | Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L. |
| title_sort | chemical composition and in vitro antioxidant and antimicrobial activities of marrubium vulgare l |
| url | http://dx.doi.org/10.1155/2021/7011493 |
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